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EME Funding Committee Minutes June 2021

Contents

MRC-NIHR funding collaboration

Meeting

EME Programme - Funding Committee Meeting

Date

Tuesday 22 and Wednesday 23 June 2021

Place

Virtual Meeting

Present - Day 1

Professor Danny McAuley (Programme Director - does not vote)
Professor John Norrie (Programme Chair - does not vote)
Professor John Petrie (Deputy Chair)
Professor Janet Dunn - (absent 10am-11am and 1pm-2pm)
Professor Daniel Freeman
Professor Jonathan Grigg
Mrs Hayley Hall (public contributor)
Professor Alastair Hay
Mr Allen Knight (public contributor)
Professor Gregory Lip
Dr Puja Mehta
Professor Michael Nicholson - (joining at 2pm)
Dr Richard Peck - (absent until 10.30am)
Professor Ruth Plummer - (absent 2.30pm-4pm)
Professor Rustam Salman
Dr Manu Shankar-Hari
Professor John Simpson
Professor Deborah Stocken
Professor Stuart Taylor
Professor Mark Thursz
Professor Chris Weir

Secretariat

Dr Dani Preedy
Dr Andrew Cook
Dr Juliana Callaghan
Miss Helen Munday
Dr Elena Harden
Dr Esther Sweeney
Ms Caitlin van Abeelen
Mrs Sue White

Apologies

Professor Arri Coomarasamy
Dr Mildred Iro
Professor Iain McInnes

Observers/in attendance

Penny Morton - MRC
Helen Hancock - RDS, North East
Ronan McCullan - New DCM - afternoon only
Tessa Cacciottolo - New TCC Member
Sophie Liddell - MRC
Sally Hickman - NETSCC - morning only
Ritchie Peckham - NETSCC - afternoon only

Stage 2 Proposals

21/17 EME Fast Track June 2021 

NIHR134607 Abhishek
Multi-centre randomised controlled trial examining the effects of interrupting low-dose methotrexate treatment for two weeks after SARS-CoV-2 vaccine booster on vaccine efficacy in immunosuppressed adults with inflammatory conditions, and nested mechanistic study
Chair: Professor John Norrie
Declared a conflict and left the meeting: 
Alastair Hay, Mark Thursz
Decision: Recommended to Programme Director to consider fund with changes

20/57 Novel strategies and interventions to reduce overtreatment

NIHR133245 Robson
Withdrawal of Immunosuppression In lupus Nephritis trial: The WIN trial
Chair: Professor John Norrie
Declared a conflict and left the meeting: Manu Shankar-Hair, Michael Nicholson
Decision: Decline

20/58 Interventions in Paediatric Care

NIHR132820 Oni
An efficient phase 3, sequential multiple assignment randomised trial (SMART) to evaluate immunosuppressive treatments for IgAV-N (The PINPOINT Trial) with integrated scientific evaluation
Chair: Professor John Norrie
Declared a conflict and left the meeting: Chris Weir, Stuart Taylor, Michael Nicholson, Helen Hancock (Observer)
Decision: Decline - invited to resubmit

NIHR133447 Rowe
Out of sight – out of mind: improving visual outcomes for children after acquired brain injury
Chair: Professor John Norrie
Declared a conflict and left the meeting: N/A
Decision: Decline

21/03 Mechanisms of Action of Health Interventions

NIHR134145 Ali
Examine the mechanisms in the potential down regulation of brain stem death induced proinflamatory responses by Simvastatin
Chair: Professor John Norrie
Declared a conflict and left the meeting: 
Chris Weir, Danny McAuley, John Simpson, Michael Nicholson, Ronan McMullan (observer), Helen Hancock (observer)
Decision: Recommended to Programme Director to consider fund with changes

20/86 EME Researcher Led

NIHR132299 Boughton
Closed-loop insulin delivery for people living with Cystic Fibrosis related diabetes (CL4P-CF)
Chair: Professor Danny McAuley
Declared a conflict and left the meeting: John Norrie, Tessa Cacciottolo (observer)
Decision: Recommended to Programme Director to consider fund with changes

19/138 EME Researcher Led

NIHR131239 Blagden
Metformin in Li Fraumeni (MILI) trial: A Phase II randomised open-label cancer prevention study of metformin in adults with Li Fraumeni Syndrome
Chair: Professor Danny McAuley
Declared a conflict and left the meeting: Chris Weir, John Norrie, Rustam Salman, Stuart Taylor
Decision: Recommended to Programme Director to consider fund with changes

NIHR132758 Garway-Heath
Nicotinamide in Glaucoma (NAMinG): a randomised, placebo-controlled, multicentre, Phase III trial
Chair: Professor John Petrie
Declared a conflict and left the meeting: John Norrie, Rustam Salman, Stuart Taylor
Decision: Recommended to Programme Director to consider fund with changes

NIHR131791 Taylor
The Efficacy of Peroneal Nerve Functional Electrical STimulation (FES) for the Reduction of Bradykinesia in Parkinson’s DiSease: An Assessor Blinded Randomised Controlled Trial (STEPS II)
Chair: Professor John Norrie
Declared a conflict and left the meeting: N/A
Decision: Decline - invited to resubmit

20/86 EME Researcher Led

NIHR133328 Farooq
SALVAGE-DEFER AMI Randomised Controlled Trial Pharmaco-Invasive Deferred Stenting and 'Minimal Touch' Primary PCI During ST-Elevation Myocardial Infarction To Salvage Myocardium – Utilising Index-of-Microcirculatory-Resistance as a Tool to Identify Patients with Failed Microvascular Reperfusion
Chair: Professor Danny McAuley
Declared a conflict and left the meeting: Chris Weir, Iain McInnes, John Norrie, John Simpson, John Petrie
Decision: Decline

NIHR133169 Majid
Efficacy and mechanism evaluation of transcutaneous vagal nerve stimulation for upper limb recovery post-stroke – a randomised, controlled, multi-arm, multi-stage, adaptive design trial
Chair: Professor John Norrie
Declared a conflict and left the meeting: Chris Weir, Iain McInnes, John Petrie
Decision: Recommended to Programme Director to consider fund with changes

19/136 Evaluating interventions for the diagnosis and treatment of Autoimmune Diseases

NIHR132636 Russell
The PULSES 2 Study: A Step Change In The Way We Treat Critical Hormone Deficiencies To Mimic Biological Processes And Reduce Side Effects
Chair: Professor John Norrie
Declared a conflict and left the meeting: Chris Weir
Decision: Decline

NIHR131359 Jones
Disease Modifying Therapy in Primary Biliary Cholangitis (PBC): A New Treatment Paradigm
Chair: Professor John Norrie
Declared a conflict and left the meeting: Chris Weir, Deborah Stocken, John Simpson, Ruth Plummer, Helen Hancock (observer), Tessa Cacciottolo (observer)
Decision: Recommended to Programme Director to consider fund with changes

19/138 EME Researcher Led

NIHR131548 Hopkinson
Dietary nitrate supplementation to enhance daily physical activity in hypoxic COPD: a randomised controlled trial
Chair: Professor John Norrie
Declared a conflict and left the meeting: Manu Shankar-Hari (not present), Mark Thursz
Decision: Recommended to Programme Director to consider fund with changes

Stage 1 Proposals

21/43 Mechanisms of action of interventions for COVID-19

NIHR134853 Chalmers
The role of neutrophils in COVID-19: analysis of the STOP-COVID19 trial
Chair: Professor John Petrie
Declared a conflict and left the meeting: John Norrie
Decision: Decline

NIHR134613 Ollivere
Mechanisms Of vacciNE effecTiveness (MONET) Prediction and risk stratification of individuals who need additional booster vaccine doses: mechanisms of immunological diversity and vaccine effectiveness against new variants of concern
Chair: Professor John Norrie
Declared a conflict and left the meeting: Stuart Taylor, Jonathan Grigg
Decision: Decline

20/86 EME Researcher Led

NIHR133517 Jha
Vaginal Laser treatment for Genitourinary Syndrome of the Menopause (GSM) following Breast Cancer: Initial feasibility trial followed by double blinded, parallel group, placebo controlled randomised trial of Efficacy
Chair: Professor John Petrie
Declared a conflict and left the meeting: Janet Dunn, John Norrie
Decision: Shortlist

Present - Day 2

Professor Danny McAuley (Programme Director - does not vote)
Professor John Norrie (Programme Chair - does not vote)
Professor John Petrie (Deputy Chair)
Professor Janet Dunn
Professor Daniel Freeman
Professor Jonathan Grigg - until 12 noon
Mrs Hayley Hall (public contributor)
Professor Alastair Hay
Mr Allen Knight (public contributor)
Professor Gregory Lip
Dr Puja Mehta
Professor Michael Nicholson
Dr Richard Peck
Professor Ruth Plummer
Professor Rustam Salman
Professor John Simpson
Professor Deborah Stocken - absent 3-4pm
Professor Stuart Taylor
Professor Chris Weir

Secretariat

Dr Dani Preedy
Dr Andrew Cook
Dr Juliana Callaghan
Miss Helen Munday
Dr Elena Harden
Dr Esther Sweeney
Ms Caitlin van Abeelen
Mrs Sue White

Apologies

Professor Arri Coomarasamy
Dr Mildred Iro
Professor Iain McInnes
Professor Mark Thursz
Dr Manu Shankar-Hari

Observers/in attendance

Penny Morton, MRC
Sophie Liddell, MRC
Dr Mark Hann, RDS - afternoon only
Hannah Sainsbury, NETSCC - morning only

Stage 1 Proposals

20/139 Mechanisms of Action of Health Interventions (pilot call of expanded remit)

NIHR134187 Burton
Mechanisms of exercise-induced cardiovascular remodelling in haemodialysis patients: the role of microRNAs in skeletal-cardiac muscle cross-talk
Chair: Professor John Norrie
Declared a conflict and left the meeting: N/A
Decision: Shortlist

NIHR134625 Bottoms
Inflammatory and cardio-metabolic mechanisms underlying the impact of exercise on young people with depression in the NIHR HTA READY Trial – an exploratory analysis
Chair: Professor John Norrie
Declared a conflict and left the meeting: N/A
Decision: Decline - waive 1 year no resubmission

NIHR134720 Jayne
Transcriptomic deconvolution to dissect the immunological mechanism of B cell depletion therapy in ANCA associated vasculitis
Chair: Professor John Norrie
Declared a conflict and left the meeting: Richard Peck, Michael Nicholson, Tessa Cacciottolo (observer)
Decision:
Shortlist

NIHR134435 Egerton
Mechanisms of action of clozapine in schizophrenia
Chair: Professor John Petrie
Declared a conflict and left the meeting: Chris Weir, Daniel Freeman, John Norrie, Manu Shankar-Hari (not present)
Decision:
Decline - waive 1 year no resubmission

NIHR134567 Taggart
Is the mechanism of action of hypertonic saline and/or carbocisteine in the treatment of patients with acute respiratory failure due to an increase in mucus hydration?
Chair: Professor John Petrie
Declared a conflict and left the meeting: Chris Weir, Danny McAuley, John Simpson, Manu Shankar-Hari (not present), John Norrie
Decision: Shortlist

NIHR134692 Mazaheri
Neuron study: Investigating the Neural mEchanisms Underlying effective thoracotomy pain chronification pRevention in paravertebral blockade compared with thOracic epidural blockade in reducing chronic post-thoracotomy paiN (TOPIC 2-NEURON)
Chair: Professor John Norrie
Declared a conflict and left the meeting: Danny McAuley
Decision: Decline

NIHR134481 Watkinson
Mechanisms for Platelets: understanding the haemostatic and inflammatory effects of platelet transfusion in critically ill patients
Chair: Professor John Petrie
Declared a conflict and left the meeting: Andrew Cook, John Norrie, Mark Thursz
Decision:
Decline - waive 1 year no resubmission

20/143 EME Researcher Led

NIHR134096 Price
Genicular Artery Embolisation for the symptomatic treatment of knee osteoarthritis refractory to conservative management (GEKO)
Chair: Professor John Norrie
Declared a conflict and left the meeting: Chris Weir, Deborah Stocken, Stuart Taylor, Janet Dunn
Decision:
Shortlist

NIHR134467 Hallifax
Randomised Controlled Trial of Air Flow-Directed Management of Primary Spontaneous Pneumothorax
Chair: Professor John Norrie
Declared a conflict and left the meeting: Mildred Iro (not present), Daniel Freeman
Decision:
Decline

NIHR134276 Rankin
SarcoSIGHT- A randomised controlled trial of fluorescence guided sarcoma surgery versus standard of care
Chair: Professor John Norrie
Declared a conflict and left the meeting: Chris Weir, John Simpson, Ruth Plummer
Decision: Shortlist

NIHR134142 Hanemann
PRedicting Outcomes, Grade and Recurrence Affecting Meningiomas using blood Biomarkers (PROGRAM Bio)
Chair: Professor John Norrie
Declared a conflict and left the meeting: Janet Dunn, Stuart Taylor
Decision: Decline - signpost to MRC

NIHR134182 Muirhead
Phase II trial investigating SABR for Patient benefit In locally Recurrent Inoperable recTal cancer (SPIRIT)
Chair: Professor John Norrie
Declared a conflict and left the meeting: Chris Weir, Iain McInnes
Decision: Shortlist

NIHR134255 Lown
CurcUmin for Pain in knee osteoArthritis (CUPA)
Chair: Professor John Norrie
Declared a conflict and left the meeting: Andrew Cook, Alastair Hay
Decision: Decline

NIHR134140 Lotery
Photodynamic laser therapy with verteporfin versus placebo for chronic central serous chorioretinopathy: the Paint RCT
Chair: Professor John Norrie
Declared a conflict and left the meeting: N/A
DDecision: Shortlist

NIHR133738 Green
Prothrombin complex concentrates versus fresh frozen plasma in adult patients who are undergoing heart surgery (PROPHESY-2 trial)
Chair: Professor John Petrie
Declared a conflict and left the meeting: Andrew Cook, Janet Dunn, John Norrie, Jonathan Grigg, Gregory Lip
Decision: Decline

NIHR134289 Yates
Semaglutide with or without exercise for improved physical function in obesity: a 68-week randomised placebo controlled trial
Chair: Professor Danny McAuley
Declared a conflict and left the meeting: John Norrie, Stuart Taylor
Decision: Decline

NIHR134609 Saglani
Azithromycin to prevent recurrent wheezing attacks in preschool children: a two-in-one randomised trial to evaluate efficacy and identify biomarkers of response
Chair: Professor John Norrie
Declared a conflict and left the meeting: Jonathan Grigg, Mark Thursz
Decision: Decline

NIHR134367 Lois
Predicting Responses to anti-VEGFs in peoplE with Diabetic macular Oedema Using Induced pluripotent stem Cell (iPSc) Technology (PREDICT)
Chair: Dr Andrew Cook
Declared a conflict and left the meeting: Danny McAuley, John Norrie
Decision: Shortlist

21/44 EME Prehabilitation: Living with and beyond cancer

NIHR134017 Sultan
STrengthening Exercise Prehabilitation during Treatment of OEsophageal cancer (STEPTOE study) - a multicentre randomised trial investigating the impact of resistance training prehabilitation on physical performance and outcomes during treatment for oesophageal cancer
Chair: Professor John Petrie
Declared a conflict and left the meeting: Andrew Cook, John Norrie, Mark Thursz, Mark Hann (observer)
Decision: Shortlist

NIHR134416 Wilson
Impact of adding a tailored physical activity (TPA) programme comprising high-intensity interval training (HIIT) to standard of care prehabilitation on disability, cardiopulmonary fitness, recovery, quality of life and cognitive function following Haematopoietic Stem Cell Transplantation (HSCT)
Chair: Professor John Norrie
Declared a conflict and left the meeting: Janet Dunn
Decision: Decline