Day 1: Tuesday 5th March 2024
Venue
The Danubius Hotel, 18 Lodge Rd, London, NW8 7JT
Present members
John Simpson (Programme Director)
John Norrie (Chair)
Maya Buch (Deputy Chair)
Victoria Allgar
Alun Bedding
Vicky Coyle
Rob Forsyth
Daniel Freeman
Hayley Hall (Public Committee Member)
George Hanna
Chandrika Kakiraj (Public Committee Member)
Patricia Limousin
Gerry McCann
Ronan McMullan
Brian Nicholson
Nuru Noor (Committee Member Development Scheme)
Philip Pallmann
Manu Shankar-Hari
Don Sharkey
David Talbot (Public Committee Member)
Stuart Taylor
Secretariat
Andrew Cook
Debbie Willis
Helen Munday
Sam Newman
Evelin Dombay
Mollie Kelly
Apologies
David Jones
Deborah Stocken
James Burton
Rajna Golubic (Committee Member Development Scheme)
Lauren Walker
Observers/In attendance
Florence Theberge
Danny McAuley
Askshay Shah
Ivan Koychev
Helen Matthews
Claire Bale
Quoracy information
- Voting members: 25
- Quorum = 17 (66%)
- Emergency Quoracy = 13 (50%)
- Voting members present on Day 1: 21
Stage 2 applications
23/53 Body fluid-based biomarkers in traumatic brain injury (EME Programme)
NIHR161839 - CLARIFY TBI: CLinical Assessment of biomaRkers In Fluid to stratifY longterm outcomes after Traumatic Brain Injury
- Chair: John Norrie
- Conflicts: Manu Shankar-Hari, Ivan Koychev (observer)
- Decision: Decline
NIHR159241 - Biomarkers for RAtional Investigation for Neurological decision Support in TBI: BRaINS-TBI
- Chair: John Norrie
- Conflicts: Ronan McMullan, Deborah Stocken (not present), Ivan Koychev (observer), Manu Shankar-Hari, Danny McAuyley (observer)
- Decision: Fund with Changes
23/57 EME Programme Researcher-led
NIHR161200 - CLOTBUST-L: An open-label, multicentre, randomised controlled trial to evaluate the efficacy of ex situ fibrinolysis during normothermic perfusion in liver transplantation from donation after circulatory death donors
- Chair: John Norrie
- Conflicts: John Simpson, David Jones (not present)
- Decision: Fund with Changes
22/162 Rehabilitation and care following stroke
NIHR159047 - Spatial Inattention Grasping Therapy (SIGHT) for rehabilitation of spatial neglect post-stroke: a randomised-controlled multicentre efficacy trial with embedded mechanistic study of determinants of therapy response
- Chair: John Norrie
- Conflicts: N/A
- Decision: Fund with Changes
23/128 EME March Fast Track
NIHR163134 - Phase II clinical trial of EXN407 - SRPK1 inhibitor eye drops for diabetic macular oedema
- Chair: John Norrie
- Conflicts: John Simpson, Ronan McMullan, Vicky Coyle, Don Sharkey, Danny McAuley (observer)
- Decision: Decline
23/57 EME Programme Researcher-led
NIHR160829 - Edmond J Safra, Accelerating Clinical Trials in Parkinson’s Disease (EJS ACT-PD) - a Multi-arm Multi-stage Platform Trial for potential disease modifying approaches
- Chair: John Norrie
- Conflicts: John Simpson, Victoria Allgar, Nuru Noor, Patricia Limousin, Stuart Taylor
- Decision: Fund with Changes
22/159 EME Programme Researcher-led
NIHR158636 - Trauma-focused therapy in early psychosis: A randomised controlled trial assessing the efficacy and mechanisms of action of Eye Movement Desensitization and Reprocessing for psychosis (EMDRp) in comparison to treatment as usual in Early Intervention settings
- Chair: Manu Shankar-Hari
- Conflicts: John Norrie, Maya Buch, Daniel Freeman
- Decision: Decline
23/57 EME Programme Researcher-led
NIHR161847 - The effect of co-enzyme Q10 supplementation on functional, physiological and metabolic biomarkers in people with heart failure with reduced ejection fraction: a mechanistic sub-study within a randomised controlled trial (CORAL mechanistic)
- Chair: John Norrie
- Conflicts: Vicky Coyle, Ronan McMullan, Philip Pallmann
- Decision: Decline
23/79 Evaluation of technologies and interventions in primary care settings
NIHR160513 - A randomised controlled trial evaluating the efficacy and mechanisms of eye movement desensitisation and reprocessing therapy (EMDR) compared with treatment as usual for adults with depression in primary care
- Chair: John Norrie
- Conflicts: Andrew Cook
- Decision: Fund with Changes
23/57 EME Programme Researcher-led
NIHR160933 - A multi-centre, double-blind, placebo-controlled randomised trial comparing a combination of methotrexate and mifepristone versus methotrexate alone as a medical treatment for tubal ectopic pregnancy (Short title - AMETHYST Trial: Adding Mifepristone to mETHotrexate for ectopic pregnancY STudy)
- Chair: Maya Buch
- Conflicts: John Simpson, John Norrie, Don Sharkey
- Decision: Fund with Changes
22/159 EME Programme Researcher-led
NIHR158537 - Rest Or Moderate Mechanical Ventilation During ECMO Support - ROMEO
- Chair: Maya Buch
- Conflicts: John Simpson, John Norrie, Ronan McMullan, George Hanna (not present), Vicky Coyle, Danny McAuley (observer), Brian Nicholson, Manu Shankar-Hari (not present)
- Decision: Fund with Changes
Day 2 - Wednesday 6th March 2024
Venue
The Danubius Hotel, 18 Lodge Rd, London, NW8 7JT
Present members
John Simpson (Programme Director)
John Norrie (Chair)
Maya Buch (Deputy Chair)
Victoria Allgar
Alun Bedding
James Burton
Vicky Coyle
Rob Forsyth
Daniel Freeman
Hayley Hall (Public Committee Member)
George Hanna
Chandrika Kakiraj (Public Committee Member)
Patricia Limousin
Gerry McCann
Ronan McMullan
Brian Nicholson
Nuru Noor (Committee Member Development Scheme)
Philip Pallmann
Manu Shankar-Hari
Don Sharkey
David Talbot (Public Committee Member)
Stuart Taylor
Secretariat
Andrew Cook
Debbie Willis
Helen Munday
Sam Newman
Evelin Dombay
Mollie Kelly
Apologies
David Jones
Deborah Stocken
Rajna Golubic (Committee Member Development Scheme)
Ivan Koychev
Maria Hassard
Lauren Walker
Observers/In attendance
Florence Theberge
Danny McAuley
Askshay Shah
Laura Ternent
Quoracy information
- Voting members: 25
- Quorum = 17 (66%)
- Emergency Quoracy = 13 (50%)
- Voting members present on Day 2: 21
Stage 1 applications
23/115 EME Programme researcher-led
NIHR163122 - Clinical Effectiveness and Mechanisms of Action of Gonadotropins for Pubertal Induction in Adolescent and Young Adult Males with Gonadotropin Deficiency; The PinG study
- Chair: John Norrie
- Conflicts: N/A
- Decision: Shortlist
NIHR162467 - Efficacy, optimal targeting and mechanisms of a video feedback parent-infant intervention for mothers and birthing persons with severe or complex perinatal mental illness
- Chair: John Norrie
- Conflicts: N/A
- Decision: Shortlist
NIHR163323 - Apixaban to Prevent dEcompensation of eArly liver CirrHosis (APEACH)
- Chair: John Norrie
- Conflicts: Andrew Cook, Deborah Stocken (not present)
- Decision: Shortlist
NIHR163722 - Mechanisms Affecting Gut of Preterm Infants receiving blood transfusion with different feed interventions - MAGPIE 2 study
- Chair: John Norrie
- Conflicts: Andrew Cook, Don Sharkey
- Decision: Decline - invited to resubmit a Stage 1 application
NIHR163493 - A peer delivered programme for mental health disclosure distress and internalised stigma (Let’s Talk) in comparison to treatment as usual in adults with psychosis: A randomised controlled trial to investigate the efficacy of a peer intervention targeted at stigma related mechanisms
- Chair: Maya Buch
- Conflicts: John Simpson, John Norrie, Daniel Freeman
- Decision: Shortlist
NIHR163760 - Preventing childhood Asthma using Prophylactic house dust mite Allergen immunotherapy
- Chair: Maya Buch
- Conflicts: John Simpson, John Norrie, Andrew Cook, Ronan McMullan, Danny McAuley (observer)
- Decision: Shortlist
NIHR163188 - COLLABORATE: An efficient, real-world-data-enabled, multicentre, 2-phase, sequential, open-label, randomised, controlled trial to assess the efficacy and safety of enteral nutrition treatments in reducing necrotising enterocolitis, mortality and neurocognitive impairment in extremely preterm babies
- Chair: Maya Buch
- Conflicts: John Simpson, John Norrie, Manu Shankar-Hari, Ronan McMullan, Philip Pallmann, Don Sharkey, Gerald McCann, Danny McAuley (observer)
- Decision: Shortlist
NIHR164336 - TRANscranial Stimulation For OCD: Efficacy and Mechanisms of Effect (TRANSForM)
- Chair: John Norrie
- Conflicts: Patricia Limousin
- Decision: Decline
NIHR164683 - Establishing the optimal combination of sequencing platform and sequencing depth to support multi-cancer early detection testing in the NHS
- Chair: John Norrie
- Conflicts: Daniel Freeman, Brian Nicholson
- Decision: Decline
23/116 NIHR James Lind Alliance Priority Setting Partnerships rolling call (EME Programme Aug 23 - Dec 23)
NIHR163138 - Randomised Controlled Trial of an Intensive Comprehensive Aphasia Programme for People with Post-Stroke Aphasia
- Chair: John Norrie
- Conflicts: Patricia Limousin
- Decision: Shortlist
NIHR163939 - Spinal Accessory Nerve Electrical stimulation in neck dissection (SANE): a randomised, double-blind multi-center efficacy & mechanism trial
- Chair: John Norrie
- Conflicts: John Simpson, Andrew Cook
- Decision: Decline - invited to resubmit a Stage 1 application
NIHR163440 - CARE for ACLR: Cross-education Rehabilitation for Anterior Cruciate Ligament Reconstruction
- Chair: John Norrie
- Conflicts: N/A
- Decision: Decline
NIHR162015 - Cavernous malformations A Randomised Efficacy Multi-arm, multi-stage trial to evaluate Aspirin and Propranolol versus standard care (CARE MAP)
- Chair: Maya Buch
- Conflicts: John Norrie, Nuru Noor, Andrew Cook, Manu Shankar-Hari, Philip Pallmann
- Decision: Decline - invited to resubmit a Stage 1 application
23/117 NIHR NICE rolling call (EME Programme Aug 23 - Dec 23)
NIHR163895 - Mechanistic and efficacy evaluation of the CRYOSTAT-2 randomised control trial of early cryoprecipitate in major trauma haemorrhage
- Chair: John Norrie
- Conflicts: N/A
- Decision: Decline - invited to resubmit a Stage 1 application
NIHR163864 - Total Neoadjuvant Treatment in Oesophageal Adenocarcinoma - The TNT-OAC Trial
- Chair: John Norrie
- Conflicts: Vicky Coyle, Andrew Cook
- Decision: Decline
NIHR164028 - Evaluation of novel pathophysiological biomarkers for diagnosis and prediction of the response to treatment in bile acid diarrhoea
- Chair: John Norrie
- Conflicts: Hayley Hall
- Decision: Decline
23/118 Palliative and End of Life Care (EME Programme)
NIHR164486 - (Psi)locybin Therapy for Rapid Treatment of Anxiety and Depression in Those With (T)erminal, (I)ncurable and (P)rogressive Disease
- Chair: John Norrie
- Conflicts: N/A
- Decision: Decline