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EME Funding Committee Minutes October 2019

 

Contents

Meeting

EME Programme - Funding Committee Meeting

Date

Tuesday 22 and Wednesday 23 October 2019

Place

Danubius Hotel, London

Present

Professor John Norrie (Programme Chair -does not vote)
Professor Eric Alton
Dr Matthew Ahearne
Dr Louise Brown
Professor Bill Deakin
Professor Janet Dunn
Professor Carrol Gamble
Professor Jonathan Grigg
Professor Ajit Lalvani
Professor Gregory Lip
Professor Iain McInnes
Professor Michael Nicholson
Dr Richard Peck
Professor John Petrie
Professor Ruth Plummer
Professor Rustam Salman
Professor Steve Thornton
Professor Mark Thursz
Professor Chris Weir

Secretariat

Dr Andrew Cook
Dr Elena Harden
Miss Helen Munday
Dr Dani Preedy
Ms Susan Solomons
Ms Abby Bull, NETSCC

Apologies

Professor Danny McAuley (Programme Director)
Ms Anne-Laure Donskoy (PPI Member)
Mr Richard Parnell (PPI Member)

Observers/In attendance

Dr Amy Gillespie, University of Oxford
Dr Victoria Cornelius, Imperial College, London
Dr Rafael Gafoor, RDS
Dr Charlotte Durkin, MRC

 

Day 1

 

Stage 2 proposals

18/168 EME Precision Medicine

NIHR128816 Pavlides
Risk stratification of patients with compensated liver cirrhosis for oesophageal varices needing treatment using MRI
Chair: Professor John Norrie
Declared a conflict and left the room:
N/A
Decision: Declined

NIHR129023 Coates
Optimising Psoriatic Arthritis Therapy with Immunological Methods to Increase Standard Evaluation (OPTIMISE)
Chair:
Professor John Norrie
Declared a conflict and left the room:
Professor Iain McInnes, Professor John Petrie
Decision:
Recommended to Programme Director to consider fund with changes

18/141 EME Chronic Pain Themed Call

NIHR129335 Al-Kaisy
The Efficacy of Dorsal Root Ganglion Burst Stimulation in the Management of Complex Regional Pain Syndrome. A Multicentre, Randomised Double-Blind Placebo-Controlled Study. “Typhoon”
Chair: Professor John Norrie
Declared a conflict and left the room:
Professor Carrol Gamble, Professor Gregory Lip and Dr Andrew Cook
Decision:
Declined – invited to resubmit 

18/170 EME Researcher Led

NIHR129318 Armstrong
Home-based EXercise and motivAtional programme before and after Liver Transplantation: ExaLT trial
Chair:
Professor John Norrie
Declared a conflict and left the room: Professor Gregory Lip, Dr Louise Brown
Decision: Declined - invited to resubmit

18/171 Dental Health - Disorders of the teeth and gums

NIHR129163 Walsh
Can a near-infrared light transillumination device be used to accurately detect caries in a general dental practice setting?  A prospective test accuracy study
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Bill Deakin
Decision: Declined

18/169 Mechanisms of Action of Health Interventions

NIHR129392 Rowland
"OSMOTIC Study" - Investigating the mechanisms of action of hyperosmolar therapy on neurological outcomes following acute severe traumatic brain injury
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Janet Dunn
Decision: Declined - invited to resubmit

19/21Mechanisms of Action of Health Interventions

NIHR129700 McPhail
MECHANISM OF BETABLOCKADE ON BACTERIAL TRANSLOCATION IN PORTAL HYPERTENSION
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Mark Thursz
Decision: Declined

NIHR129960 Carrol
MR-PRo-adrenomedullin (MR-proADM) and ImmunoXpert Evaluation of procalcitonin-guided antibiotic duration in Children with Infection for Stratification of Effectiveness (PRECISE)
Chair:
Professor John Norrie
Declared a conflict and left the room:
Professor Gregory Lip, Professor Carrol Gambe and Professor Chris Weir
Decision: Recommended to Programme Director to consider fund with change

NIHR130192 Taggart
Is the mechanism of action of hypertonic saline and/or carbocisteine in the treatment of patients with bronchiectasis due to a decrease in sputum viscoelasticity, inflammation and bacterial load?
Chair:
Dr Andrew Cook
Declared a conflict and left the room:
Professor John Norrie, Dr Louise Brown, Professor Ruth Plummer, Professor Chris Weir and Professor Eric Alton
Decision:
Recommended to Programme Director to consider fund with changes

18/170 EME Researcher Led

NIHR128980 Dhillo
Using kisspeptin to trigger oocyte maturation to improve the safety of IVF treatment
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Ajit Lalvani, Professor Eric Alton, Professor Mark Thursz and Professor Victoria Cornelius (observer)
Decision: Declined

Stage 1 Proposals

19/24 EME Researcher Led

NIHR129674 Price
The efficacy of feedback from a novel wristband accelerometer worn at home to enhance arm recovery after stroke: a multi-arm multi-stage randomised controlled trial 
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Ruth Plummer and Professor Chris Weir
Decision: Shortlisted

18/170 EME Researcher Led

NIHR128778 Grigg
Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis; a randomised placebo controlled trial (BLIPA; Bacterial Lysate in Preventing Asthma)
Chair: Dr Andrew Cook
Declared a conflict and left the room: Professor John Norrie, Professor Gregory Lip, Professor Carrol Gamble, Professor Jonathan Grigg, Professor Chris Weir and Professor Rustam Salman
Decision: Shortlisted

18/125 EME Researcher Led

NIHR128591 Mehta
Improving Memory in Schizophrenia with PDE4 inibitor Roflumilast
Chair: Professor Eric Alton
Declared a conflict and left the room: Professor John Norrie and Professor Bill Deakin
Decision: Declined

19/24 EME Researcher Led

NIHR130048 Papadopoulos
Duroplasty for Injured cervical Spinal Cord with Uncontrolled Swelling (DISCUS): a randomised controlled trial
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Michael Nicholson
Decision: Shortlisted

18/168 EME Precision Medicine

NIHR128878 Noursadeghi
Precision RnA Guided Management of Tuberculosis Contacts (PRAGMATIC) 1
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Eric Alton, Dr Louise Brown, Professor Ajit Lalvani, Professor Mark Thursz and Dr Victoria Cornelius (observer)
Decision: Declined

19/24 EME Researcher Led

NIHR130479 Costa
World Hip Trauma Evaluation - DeCI: Delirium and Cognitive Impairment
Chair: Professor John Norrie
Declared a conflict and left the room: N/A
Decision: Shortlisted

NIHR129819 Turner
SPIROMAC - SPIROmetry to Manage Asthma in Children
Chair: Dr Andrew Cook
Declared a conflict and left the room: Professor John Norrie, Professor Matthew Ahearne, Professor Jonathan Grigg and Professor Carrol Gamble
Decision: Declined - invited to resubmit

NIHR129910 Wilson
The efficacy of n-3 polyunsaturated fatty acids in people with aspirin exacerbated airways disease and uncontrolled asthma
Chair: Dr Andrew Cook
Declared a conflict and left the room: Professor John Norrie, Dr Louise Brown, Professor Michael Nicholson, Professor Chris Weir and Professor Rustam Salman
Decision: Shortlisted

NIHR129875 Forsyth
Seizure via pH manipulation: a phase IIa RCT of inhaled carbogen as adjunctive treatment of paediatric convulsive status epilepticus (CSE)
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Gregory Lip, Professor Carrol Gamble and Professor Ruth Plummer
Decision: Shortlisted

Day 2

Present

Professor John Norrie (Programme Chair -does not vote)
Professor Eric Alton
Dr Matthew Ahearne
Dr Louise Brown
Professor Bill Deakin
Professor Jonathan Grigg
Professor Ajit Lalvani
Professor Gregory Lip
Professor Iain McInnes
Professor Michael Nicholson
Dr Richard Peck
Professor John Petrie
Professor Ruth Plummer
Professor Mark Thursz
Professor Chris Weir

Secretariat

Mr Simon Bevan, NETSCC
Miss Helen Munday
Dr Dani Preedy
Ms Susan Solomons

Apologies

Professor Danny McAuley (Programme Director)
Ms Anne-Laure Donskoy (PPI)
Mr Richard Parnell (PPI)
Professor Janet Dunn
Professor Carrol Gamble
Professor Rustam Salman
Professor Steve Thornton
Dr Andrew Cook

Observers/In attendance

Dr Ellen Donovan, RDS
Dr Charlotte Durkin, MRC

Stage 1 Proposals

18/170 EME Researcher Led

NIHR12340 Limousin
Double blind comparison of optimised Deep Brain Stimulation for severe Tourette syndrome
Chair: Professor John Norrie
Declared a conflict and left the room: Dr Louise Brown
Decision: Shortlisted

19/24 EME Researcher Led

NIHR130406 McSorley
CORTISONE: CORticosteroids To reduce Inflammation and improve Short-term Outcomes after surgery for colorectal NEoplasia
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Iain McInnes and Professor John Petrie
Decision: Declined

19/24 EME Researcher Led

NIHR130465 Vilar
AV fistula maturation: effect of remote ischaemic pre-conditioning and hand exercise
Chair: Professor John Norrie
Declared a conflict and left the room: N/A
Decision: Declined

NIHR130043 Ehrenstein
Anti-TNF biologic tapering: a multi-centre cohort study using regulatory T cell biomarkers to predict maintenance of remission in rheumatoid arthritis
Chair: Professor John Norrie
Declared a conflict and left the room: Dr Louise Brown, Professor Bill Deakin, Professor Iain McInnes, Professor John Petrie and Professor Ruth Plummer
Decision: Declined

19/62 Epigenetics

NIHR129863 Mackay
Does targeted imprinting disorder diagnostics by next-generation sequencing increase detection to facilitate early intervention for congenital imprinting disorders?
Chair: Professor John Norrie
Declared a conflict and left the room: N/A
Decision: Declined – invited to resubmit 

NIHR129876 Muir
To utilise epigenomic profiling to improve the NHS lung health check
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Bill Deakin
Decision: Declined

19/24 EME Researcher Led

NIHR130077 Rubia
Effects of external Trigeminal Nerve Stimulation in ADHD and mechanisms of action
Chair: Professor John Norrie
Declared a conflict and left the room: N/A
Decision: Shortlisted

19/24 EME Researcher Led

NIHR130047 Corrie
A phase II study combining Pembrolizumab with Olaparib in metastatic pancreatic adenocarcinoma patients with high tumour mutation burden
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Michael Nicholson and Professor John Petrie
Decision: Shortlisted

19/61 Mitigation of the adverse effects of health and social care interventions

NIHR130331 Drobniewski
Protecting Hearing In Cancer and Antimicrobial therapy: N-acetylcysteine - a single-blind randomised controlled trial (PHICAN)
Chair: Professor John Norrie
Declared a conflict and left the room:Professor Mark Thursz, Professor Eric Alton and Professor Ajit Lalvani
Decision: Declined – invited to resubmit 

NIHR130133 Leff
Primary Radiotherapy And DIEP Flap Reconstruction–II (PRADA-II)
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Eric Alton, Professor Ajit Lalvani, Professor Mark Thursz and Dr Ellen Donovan (observer)
Decision: Declined – invited to resubmit

NIHR130544 Simon
Mitigation of severe adverse events of heart transplantation by Cytosorb targeting surgical inflammation using novel cytokine removal therapy: The CYCLONE-HEART Tx study
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Eric Alton, Professor Bill Deakin, Professor Ajit Lalvani, Professor Ruth Plummer and Professor Mark Thursz
Decision: Declined

Outcomes Table

Stage 2 Proposals

The EME Funding Committee recommended the following Stage 2 proposals for either immediate funding or for funding subject to certain conditions

Commissioned

Project ReferenceLead ApplicantInstitutionProject Title
NIHR129023 Dr Laura Coates University of Oxford Optimising Psoriatic Arthritis Therapy with Immunological Methods to Increase Standard Evaluation (OPTIMISE)
NIHR129960 Professor Enitan Carrol University of Liverpool MR-PRo-adrenomedullin (MR-proADM) and ImmunoXpert Evaluation of procalcitonin-guided antibiotic duration in Children with Infection for Stratification of Effectiveness (PRECISE)
NIHR130192 Professor Cliff Taggart Queen's University of Belfast Is the mechanism of action of hypertonic saline and/or carbocisteine in the treatment of patients with bronchiectasis due to a decrease in sputum viscoelasticity, inflammation and bacterial load?

Further information on the above projects will be provided on the EME website once the project has started.

Stage 1 Proposals

The following Stage 1 proposals have been shortlisted to submit a Stage 2 application for consideration by the EME Funding Committee at its next meeting

Researcher Led

Project ReferenceLead ApplicantInstitutionProject Title
NIHR128778 Professor Jonathan Grigg Queen Mary University of London Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis; a randomised placebo controlled trial (BLIPA; Bacterial Lysate in Preventing Asthma)
NIHR130048 Professor Marios Papadopoulos St George's, University of London Duroplasty for Injured cervical Spinal Cord with Uncontrolled Swelling (DISCUS): a randomised controlled trial
NIHR130479 Professor Matthew Costa University of Oxford World Hip Trauma Evaluation - DeCI: Delirium and Cognitive Impairment
NIHR129910 Professor Andrew Wilson University of East Anglia The efficacy of n-3 polyunsaturated fatty acids in people with aspirin exacerbated airways disease and uncontrolled asthma
NIHR129875 Dr Rob Forsyth Newcastle Upon Tyne Hospitals NHS Foundation Trust Seizure via pH manipulation: a phase IIa RCT of inhaled carbogen as adjunctive treatment of paediatric convulsive status epilepticus (CSE)
NIHR129340 Professor Patricia Limousin UCL Partners Double blind comparison of optimised Deep Brain Stimulation for severe Tourette syndrome
NIHR129674 Dr Chris Price University of Newcastle The efficacy of feedback from a novel wristband accelerometer worn at home to enhance arm recovery after stroke: a multi-arm multi-stage randomised controlled trial
NIHR130077 Professor Katya Rubia King's College London Effects of external Trigeminal Nerve Stimulation in ADHD and mechanisms of action
NIHR130047 Dr Pippa Corrie Cambridge University Hospitals NHS Foundation Trust A phase II study combining Pembrolizumab with Olaparib in metastatic pancreatic adenocarcinoma patients with high tumour mutation burden