Meeting
EME Programme - Funding Committee Meeting
Date
Tuesday 22 and Wednesday 23 October 2019
Place
Danubius Hotel, London
Present
Professor John Norrie (Programme Chair -does not vote)
Professor Eric Alton
Dr Matthew Ahearne
Dr Louise Brown
Professor Bill Deakin
Professor Janet Dunn
Professor Carrol Gamble
Professor Jonathan Grigg
Professor Ajit Lalvani
Professor Gregory Lip
Professor Iain McInnes
Professor Michael Nicholson
Dr Richard Peck
Professor John Petrie
Professor Ruth Plummer
Professor Rustam Salman
Professor Steve Thornton
Professor Mark Thursz
Professor Chris Weir
Secretariat
Dr Andrew Cook
Dr Elena Harden
Miss Helen Munday
Dr Dani Preedy
Ms Susan Solomons
Ms Abby Bull, NETSCC
Apologies
Professor Danny McAuley (Programme Director)
Ms Anne-Laure Donskoy (PPI Member)
Mr Richard Parnell (PPI Member)
Observers/In attendance
Dr Amy Gillespie, University of Oxford
Dr Victoria Cornelius, Imperial College, London
Dr Rafael Gafoor, RDS
Dr Charlotte Durkin, MRC
Day 1
Stage 2 proposals
18/168 EME Precision Medicine
NIHR128816 Pavlides
Risk stratification of patients with compensated liver cirrhosis for oesophageal varices needing treatment using MRI
Chair: Professor John Norrie
Declared a conflict and left the room: N/A
Decision: Declined
NIHR129023 Coates
Optimising Psoriatic Arthritis Therapy with Immunological Methods to Increase Standard Evaluation (OPTIMISE)
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Iain McInnes, Professor John Petrie
Decision: Recommended to Programme Director to consider fund with changes
18/141 EME Chronic Pain Themed Call
NIHR129335 Al-Kaisy
The Efficacy of Dorsal Root Ganglion Burst Stimulation in the Management of Complex Regional Pain Syndrome. A Multicentre, Randomised Double-Blind Placebo-Controlled Study. “Typhoon”
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Carrol Gamble, Professor Gregory Lip and Dr Andrew Cook
Decision: Declined – invited to resubmit
18/170 EME Researcher Led
NIHR129318 Armstrong
Home-based EXercise and motivAtional programme before and after Liver Transplantation: ExaLT trial
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Gregory Lip, Dr Louise Brown
Decision: Declined - invited to resubmit
18/171 Dental Health - Disorders of the teeth and gums
NIHR129163 Walsh
Can a near-infrared light transillumination device be used to accurately detect caries in a general dental practice setting? A prospective test accuracy study
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Bill Deakin
Decision: Declined
18/169 Mechanisms of Action of Health Interventions
NIHR129392 Rowland
"OSMOTIC Study" - Investigating the mechanisms of action of hyperosmolar therapy on neurological outcomes following acute severe traumatic brain injury
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Janet Dunn
Decision: Declined - invited to resubmit
19/21Mechanisms of Action of Health Interventions
NIHR129700 McPhail
MECHANISM OF BETABLOCKADE ON BACTERIAL TRANSLOCATION IN PORTAL HYPERTENSION
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Mark Thursz
Decision: Declined
NIHR129960 Carrol
MR-PRo-adrenomedullin (MR-proADM) and ImmunoXpert Evaluation of procalcitonin-guided antibiotic duration in Children with Infection for Stratification of Effectiveness (PRECISE)
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Gregory Lip, Professor Carrol Gambe and Professor Chris Weir
Decision: Recommended to Programme Director to consider fund with change
NIHR130192 Taggart
Is the mechanism of action of hypertonic saline and/or carbocisteine in the treatment of patients with bronchiectasis due to a decrease in sputum viscoelasticity, inflammation and bacterial load?
Chair: Dr Andrew Cook
Declared a conflict and left the room: Professor John Norrie, Dr Louise Brown, Professor Ruth Plummer, Professor Chris Weir and Professor Eric Alton
Decision: Recommended to Programme Director to consider fund with changes
18/170 EME Researcher Led
NIHR128980 Dhillo
Using kisspeptin to trigger oocyte maturation to improve the safety of IVF treatment
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Ajit Lalvani, Professor Eric Alton, Professor Mark Thursz and Professor Victoria Cornelius (observer)
Decision: Declined
Stage 1 Proposals
19/24 EME Researcher Led
NIHR129674 Price
The efficacy of feedback from a novel wristband accelerometer worn at home to enhance arm recovery after stroke: a multi-arm multi-stage randomised controlled trial
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Ruth Plummer and Professor Chris Weir
Decision: Shortlisted
18/170 EME Researcher Led
NIHR128778 Grigg
Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis; a randomised placebo controlled trial (BLIPA; Bacterial Lysate in Preventing Asthma)
Chair: Dr Andrew Cook
Declared a conflict and left the room: Professor John Norrie, Professor Gregory Lip, Professor Carrol Gamble, Professor Jonathan Grigg, Professor Chris Weir and Professor Rustam Salman
Decision: Shortlisted
18/125 EME Researcher Led
NIHR128591 Mehta
Improving Memory in Schizophrenia with PDE4 inibitor Roflumilast
Chair: Professor Eric Alton
Declared a conflict and left the room: Professor John Norrie and Professor Bill Deakin
Decision: Declined
19/24 EME Researcher Led
NIHR130048 Papadopoulos
Duroplasty for Injured cervical Spinal Cord with Uncontrolled Swelling (DISCUS): a randomised controlled trial
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Michael Nicholson
Decision: Shortlisted
18/168 EME Precision Medicine
NIHR128878 Noursadeghi
Precision RnA Guided Management of Tuberculosis Contacts (PRAGMATIC) 1
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Eric Alton, Dr Louise Brown, Professor Ajit Lalvani, Professor Mark Thursz and Dr Victoria Cornelius (observer)
Decision: Declined
19/24 EME Researcher Led
NIHR130479 Costa
World Hip Trauma Evaluation - DeCI: Delirium and Cognitive Impairment
Chair: Professor John Norrie
Declared a conflict and left the room: N/A
Decision: Shortlisted
NIHR129819 Turner
SPIROMAC - SPIROmetry to Manage Asthma in Children
Chair: Dr Andrew Cook
Declared a conflict and left the room: Professor John Norrie, Professor Matthew Ahearne, Professor Jonathan Grigg and Professor Carrol Gamble
Decision: Declined - invited to resubmit
NIHR129910 Wilson
The efficacy of n-3 polyunsaturated fatty acids in people with aspirin exacerbated airways disease and uncontrolled asthma
Chair: Dr Andrew Cook
Declared a conflict and left the room: Professor John Norrie, Dr Louise Brown, Professor Michael Nicholson, Professor Chris Weir and Professor Rustam Salman
Decision: Shortlisted
NIHR129875 Forsyth
Seizure via pH manipulation: a phase IIa RCT of inhaled carbogen as adjunctive treatment of paediatric convulsive status epilepticus (CSE)
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Gregory Lip, Professor Carrol Gamble and Professor Ruth Plummer
Decision: Shortlisted
Day 2
Present
Professor John Norrie (Programme Chair -does not vote)
Professor Eric Alton
Dr Matthew Ahearne
Dr Louise Brown
Professor Bill Deakin
Professor Jonathan Grigg
Professor Ajit Lalvani
Professor Gregory Lip
Professor Iain McInnes
Professor Michael Nicholson
Dr Richard Peck
Professor John Petrie
Professor Ruth Plummer
Professor Mark Thursz
Professor Chris Weir
Secretariat
Mr Simon Bevan, NETSCC
Miss Helen Munday
Dr Dani Preedy
Ms Susan Solomons
Apologies
Professor Danny McAuley (Programme Director)
Ms Anne-Laure Donskoy (PPI)
Mr Richard Parnell (PPI)
Professor Janet Dunn
Professor Carrol Gamble
Professor Rustam Salman
Professor Steve Thornton
Dr Andrew Cook
Observers/In attendance
Dr Ellen Donovan, RDS
Dr Charlotte Durkin, MRC
Stage 1 Proposals
18/170 EME Researcher Led
NIHR12340 Limousin
Double blind comparison of optimised Deep Brain Stimulation for severe Tourette syndrome
Chair: Professor John Norrie
Declared a conflict and left the room: Dr Louise Brown
Decision: Shortlisted
19/24 EME Researcher Led
NIHR130406 McSorley
CORTISONE: CORticosteroids To reduce Inflammation and improve Short-term Outcomes after surgery for colorectal NEoplasia
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Iain McInnes and Professor John Petrie
Decision: Declined
19/24 EME Researcher Led
NIHR130465 Vilar
AV fistula maturation: effect of remote ischaemic pre-conditioning and hand exercise
Chair: Professor John Norrie
Declared a conflict and left the room: N/A
Decision: Declined
NIHR130043 Ehrenstein
Anti-TNF biologic tapering: a multi-centre cohort study using regulatory T cell biomarkers to predict maintenance of remission in rheumatoid arthritis
Chair: Professor John Norrie
Declared a conflict and left the room: Dr Louise Brown, Professor Bill Deakin, Professor Iain McInnes, Professor John Petrie and Professor Ruth Plummer
Decision: Declined
19/62 Epigenetics
NIHR129863 Mackay
Does targeted imprinting disorder diagnostics by next-generation sequencing increase detection to facilitate early intervention for congenital imprinting disorders?
Chair: Professor John Norrie
Declared a conflict and left the room: N/A
Decision: Declined – invited to resubmit
NIHR129876 Muir
To utilise epigenomic profiling to improve the NHS lung health check
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Bill Deakin
Decision: Declined
19/24 EME Researcher Led
NIHR130077 Rubia
Effects of external Trigeminal Nerve Stimulation in ADHD and mechanisms of action
Chair: Professor John Norrie
Declared a conflict and left the room: N/A
Decision: Shortlisted
19/24 EME Researcher Led
NIHR130047 Corrie
A phase II study combining Pembrolizumab with Olaparib in metastatic pancreatic adenocarcinoma patients with high tumour mutation burden
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Michael Nicholson and Professor John Petrie
Decision: Shortlisted
19/61 Mitigation of the adverse effects of health and social care interventions
NIHR130331 Drobniewski
Protecting Hearing In Cancer and Antimicrobial therapy: N-acetylcysteine - a single-blind randomised controlled trial (PHICAN)
Chair: Professor John Norrie
Declared a conflict and left the room:Professor Mark Thursz, Professor Eric Alton and Professor Ajit Lalvani
Decision: Declined – invited to resubmit
NIHR130133 Leff
Primary Radiotherapy And DIEP Flap Reconstruction–II (PRADA-II)
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Eric Alton, Professor Ajit Lalvani, Professor Mark Thursz and Dr Ellen Donovan (observer)
Decision: Declined – invited to resubmit
NIHR130544 Simon
Mitigation of severe adverse events of heart transplantation by Cytosorb targeting surgical inflammation using novel cytokine removal therapy: The CYCLONE-HEART Tx study
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Eric Alton, Professor Bill Deakin, Professor Ajit Lalvani, Professor Ruth Plummer and Professor Mark Thursz
Decision: Declined
Outcomes Table
Stage 2 Proposals
The EME Funding Committee recommended the following Stage 2 proposals for either immediate funding or for funding subject to certain conditions
Commissioned
| Project Reference | Lead Applicant | Institution | Project Title |
|---|---|---|---|
| NIHR129023 | Dr Laura Coates | University of Oxford | Optimising Psoriatic Arthritis Therapy with Immunological Methods to Increase Standard Evaluation (OPTIMISE) |
| NIHR129960 | Professor Enitan Carrol | University of Liverpool | MR-PRo-adrenomedullin (MR-proADM) and ImmunoXpert Evaluation of procalcitonin-guided antibiotic duration in Children with Infection for Stratification of Effectiveness (PRECISE) |
| NIHR130192 | Professor Cliff Taggart | Queen's University of Belfast | Is the mechanism of action of hypertonic saline and/or carbocisteine in the treatment of patients with bronchiectasis due to a decrease in sputum viscoelasticity, inflammation and bacterial load? |
Further information on the above projects will be provided on the EME website once the project has started.
Stage 1 Proposals
The following Stage 1 proposals have been shortlisted to submit a Stage 2 application for consideration by the EME Funding Committee at its next meeting
Researcher Led
| Project Reference | Lead Applicant | Institution | Project Title |
|---|---|---|---|
| NIHR128778 | Professor Jonathan Grigg | Queen Mary University of London | Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis; a randomised placebo controlled trial (BLIPA; Bacterial Lysate in Preventing Asthma) |
| NIHR130048 | Professor Marios Papadopoulos | St George's, University of London | Duroplasty for Injured cervical Spinal Cord with Uncontrolled Swelling (DISCUS): a randomised controlled trial |
| NIHR130479 | Professor Matthew Costa | University of Oxford | World Hip Trauma Evaluation - DeCI: Delirium and Cognitive Impairment |
| NIHR129910 | Professor Andrew Wilson | University of East Anglia | The efficacy of n-3 polyunsaturated fatty acids in people with aspirin exacerbated airways disease and uncontrolled asthma |
| NIHR129875 | Dr Rob Forsyth | Newcastle Upon Tyne Hospitals NHS Foundation Trust | Seizure via pH manipulation: a phase IIa RCT of inhaled carbogen as adjunctive treatment of paediatric convulsive status epilepticus (CSE) |
| NIHR129340 | Professor Patricia Limousin | UCL Partners | Double blind comparison of optimised Deep Brain Stimulation for severe Tourette syndrome |
| NIHR129674 | Dr Chris Price | University of Newcastle | The efficacy of feedback from a novel wristband accelerometer worn at home to enhance arm recovery after stroke: a multi-arm multi-stage randomised controlled trial |
| NIHR130077 | Professor Katya Rubia | King's College London | Effects of external Trigeminal Nerve Stimulation in ADHD and mechanisms of action |
| NIHR130047 | Dr Pippa Corrie | Cambridge University Hospitals NHS Foundation Trust | A phase II study combining Pembrolizumab with Olaparib in metastatic pancreatic adenocarcinoma patients with high tumour mutation burden |