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HTA Funding Committee Public Minutes 05-06 November 2019

 

Contents

Day 1: 05 November 2019, Danubius Hotel, London

Present

Members

  • Professor Lucy Chappell (Chair)
  • Professor Julia Brown (Deputy Chair)
  • Professor Hywel Williams (HTA Programme Director)
  • Ms Gail Thornton (PPI representative)
  • Mrs Deborah Keatley (PPI representative)
  • Professor Tim Coleman
  • Professor Edwin Van Teijlingen
  • Professor William Hollingworth
  • Professor Daniel Lasserson
  • Dr Susan Jowett
  • Dr Kate Brown
  • Professor Richard Emsley
  • Professor Scott Weich
  • Dr Kathryn Radford
  • Professor Alan Montgomery
  • Professor Steph Taylor
  • Dr Jennifer Logue
  • Professor Thomas Pinkney
  • Dr Charlotte Coles
  • Dr Sharon Simpson
  • Professor Sally Hopewell
  • Dr Natalie Blencowe
  • Ms Jo Haviland
  • Dr Elena Pizzo
  • Professor Kapil Sayal
  • Dr Daniel Hind

NETSCC, HTA Secretariat

  • Dr Martin Ashton-Key (Consultant Advisor, NETSCC)
  • Steph Garfield-Birkbeck (Head of the HTA Programme Secretariat)
  • Mrs Karen Williams (Senior Research Manager)
  • Dr Cristina Lujan Barroso (Research Manager)
  • Miss Constance Temple-Brown (Assistant Research Manager)
  • Miss Alessandra Wilkinson-Smith (Assistant Research Manager)

Apologies

Professor Rebecca Kearney, Dr David Ekers, Professor Daniel Prieto-Alhambra, Dr David Weller

Observers

None

Quoracy Information

  • Voting members: 28 Quorum = 19
  • Voting members present on Day 1: 24 (86%)

Commissioned Stage 2 Proposals

19/07: Anti-tuberculosis drug hepatotoxicity and treatment reintroduction

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Kathryn Radford, Professor Kapil Sayal, Professor Tim Coleman

  • NIHR129515: Reintroduction of anti-tuberculosis therapy following drug-induced liver injury: a randomised clinical trial
    (Honorary Professor Wei Shen Lim, Nottingham University Hospitals NHS Trust)
    Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

Researcher-Led Stage 2 Applications and Tobacco Call

18/166: HTA Tobacco Cessation, control and harm reduction interventions

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Daniel Hind, Dr Jennifer Logue, Dr Kathryn Radford, Professor Kapil Sayal, Professor Tim Coleman

Arrived meeting: Julia Brown

  • NIHR129210: Open-label randomised controlled trial of nicotine replacement therapy (NRT) for preloading, lapse recovery and smoking reduction: impact on smoking in pregnancy
    (Professor Tim Coleman, The University of Nottingham)
    Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/11: HTA Researcher-led call Primary Research

Chair: Professor Lucy Chappell

Declared a conflict and left the room: None

Arrived meeting: Alan Montgomery

  • NIHR129748: Surgeons Trial Of Prophylaxis for Epilepsy in seizure naïve patients with Meningioma: a randomised controlled trial (STOP’EM)
    (Mr Michael Jenkinson, University of Liverpool)
    Funding Committee recommendation: Stage 2 resubmission

19/11: HTA Researcher-led call Primary Research

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Susan Jowett, Professor Daniel Lasserson

  • NIHR129179: PREDNOS 3: what is the optimal steroid treatment dose to induce remission in relapses of childhood nephrotic syndrome?
    (Dr Martin Christian, Nottingham University Hospitals NHS Trust)
    Funding Committee recommendation: Decline

18/166: HTA Tobacco Cessation, control and harm reduction interventions

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Susan Jowett, Professor Daniel Lasserson, Professor Thomas Pinkney, Professor Tim Coleman

Arrived meeting: Hywel Williams

  • NIHR129593: Investigating the effectiveness of electronic cigarettes as an aid to smoking cessation in comparison with varenicline and the effect of vaping on lung health in patients with chronic obstructive pulmonary disease (E-CaL study)
    (Dr Amanda Farley, University of Birmingham)
    Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/11: HTA Researcher-led call Primary Research

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Professor Sharon Simpson

  • NIHR129707: UrodynAmicS as Routine Evaluation in Women with StrEss UrinaRy InconTinence (The ASSERT Study); a superiority randomised clinical trial to evaluate the clinical and cost effectiveness of routine urodynamic investigations in management of women with stress urinary incontinence.
    (Professor Mohamed Abdel-Fattah, University of Aberdeen)
    Funding Committee recommendation: Decline

19/11: HTA Researcher-led call Primary Research

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Elena Pizzo, Dr Jennifer Logue

  • NIHR127873: Pragmatic randomised trial of High Or Standard PHosphAte Targets in End-stage kidney disease - The PHOSPHATE trial
    (Dr Thomas Hiemstra, University of Cambridge)
    Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

18/166: HTA Tobacco Cessation, control and harm reduction interventions

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Susan Jowett, Professor Lucy Chappell, Professor Richard Emsley, Professor Tim Coleman

  • NIHR129627: Do e-cigarettes help smokers quit when not accompanied by intensive behavioural support?
    (Dr Katie Myers Smith, Barts & The London School of Medicine & Dentistry)
    Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/11: HTA Researcher-led call Primary Research

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Susan Jowett, Professor Sharon Simpson, Professor Stephanie Taylor

  • NIHR129649: A multicentre randomised placebo-controlled trial of the effectiveness and cost-effectiveness of conventional vs high-frequency spinal cord stimulation in patients with neuropathic pain. CHESTNUT STUDY.
    (Professor Sam Eldabe, South Tees Hospitals NHS Foundation Trust)
    Funding Committee recommendation: Decline

19/11: HTA Researcher-led call Primary Research

Chair: Professor Lucy Chappell

Declared a conflict and left the room: None

  • NIHR129589: ORBITA-2: A placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina
    (Professor Darrel Francis, Imperial College London)
    Funding Committee recommendation: Decline

Commissioned Stage 1 Applications

19/26: Maternal intrapartum glycaemic control

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Jennifer Logue, Professor Alan Montgomery, Professor Hywel Williams, Professor Lucy Chappell, Professor Sharon Simpson

  • NIHR130175: Glycaemic control in labour with Diabetes (GILD)
    (Dr Nia Jones, The University of Nottingham)
    Funding Committee recommendation: Shortlist
  • NIHR130403: MAternal iNtrapartum Glycaemic cOntrol: MANGO study
    (Professor Fiona Denison, The University of Edinburgh)
    Funding Committee recommendation: Shortlist
  • NIHR130491: HTA no 19/26, Maternal intrapartum glycaemic control
    (Dr Edward Mullins, Imperial College London)
    Funding Committee recommendation: Decline

19/25: Anaesthesia for arteriovenous fistula formation

Chair: Dr Charlotte Coles

Declared a conflict and left the room: Dr Daniel Hind, Dr Elena Pizzo, Dr Jennifer Logue, Dr Kathryn Radford, Dr Natalie Blencowe, Dr Susan Jowett, Ms Gail Thornton, Professor Alan Montgomery, Professor Daniel Lasserson, Professor Hywel Williams, Professor Julia Brown, Professor Lucy Chappell, Professor Sharon Simpson, Professor Thomas Pinkney, Professor William Hollingworth, Professor Scott Weich

  • NIHR129965: BRachial plexus block for ArterioVEnous fistula formation: The BRAVE trial.
    (Dr Michael Robson, King's College London)
    Funding Committee recommendation: Decline
  • NIHR130564: A multicentre randomised control trial comparing local anaesthetic infiltration against regional anaesthesia for arteriovenous fistula creation: the VALARA (Vascular Access Local Anaesthetic Regional Anaesthetic) Trial.
    (Mr Gavin Pettigrew, University of Cambridge)
    Funding Committee recommendation: Decline
  • NIHR130567: Anaesthesia Choice for Creation of ArtEriovenous FiStulae (ACCESs study) A randomised controlled trial comparing clinical (one-year functional patency rate) and cost-effectiveness of regional versus local anaesthesia for primary arteriovenous fistula formation
    (Ms Emma Aitken, The Queen Elizabeth University Hospital Glasgow)
    Funding Committee recommendation: Shortlist
  • NIHR130600: Local Anaesthesia versus Regional Anaesthesia for primary arteriovenous fistula (AVF) formation surgery: the LARA study
    (Dr Ronelle Mouton, North Bristol NHS Trust)
    Funding Committee recommendation: Shortlist
  • NIHR130609: A pragmatic randomised controlled trial to investigate the effect of Local Anaesthesia (LA) and Regional Anaesthesia (RA) on formation of functional arterio-venous fistula for haemodialysis: The LaRa Trial
    (Mr Maciej Juszczak, University Hospitals Birmingham NHS Foundation Trust)
    Funding Committee recommendation: Decline (a show of hands vote took place to assess the support for the proposal: 4 supported, 5 did not 

 

Day 2: 06 November 2019, Danubius Hotel, London

Present

Members

  • Professor Lucy Chappell (Chair)
  • Professor Julia Brown (Deputy Chair)
  • Professor Hywel Williams (HTA Programme Director)
  • Ms Gail Thornton (PPI representative)
  • Mrs Deborah Keatley (PPI representative)
  • Professor Tim Coleman
  • Professor Edwin Van Teijlingen
  • Professor William Hollingworth
  • Dr Susan Jowett
  • Dr Kate Brown
  • Professor Richard Emsley
  • Professor Scott Weich
  • Dr Kathryn Radford
  • Professor Alan Montgomery
  • Professor Steph Taylor
  • Dr Jennifer Logue
  • Professor Thomas Pinkney
  • Dr Charlotte Coles
  • Dr Sharon Simpson
  • Professor Sally Hopewell
  • Ms Jo Haviland
  • Dr Elena Pizzo
  • Professor Kapil Sayal
  • Dr Daniel Hind

NETSCC, HTA Secretariat

  • Dr Martin Ashton-Key (Consultant Advisor, NETSCC)
  • Steph Garfield-Birkbeck (Head of the HTA Programme Secretariat)
  • Mrs Karen Williams (Senior Research Manager)
  • Dr Cristina Lujan Barroso (Research Manager)
  • Miss Constance Temple-Brown (Assistant Research Manager)

Apologies

Rebecca Kearney, David Ekers, Daniel Lasserson, Natalie Blencowe, Dr David Weller, Professor Daniel Prieto-Alhambra

Observers

None

Quoracy Information

  • Voting members: 28 Quorum = 19
  • Voting members present on Day 2: 23 (82%)

Commissioning Stage 1 proposals

19/27: Peritoneal endometriosis: To treat or not?

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Kathryn Radford, Professor Alan Montgomery, Professor Hywel Williams, Professor Sharon Simpson, Professor Thomas Pinkney

  • NIHR129801: ESPriT2: A multi-centre randomised controlled trial to determine the effectiveness of laparoscopic treatment of isolated superficial peritoneal endometriosis for the management of chronic pelvic pain in women
    (Professor Andrew Horne, The University of Edinburgh)
    Committee recommendation: Shortlist

19/53: Rivastigmine for psychotic symptoms associated with Parkinson’s disease

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Daniel Hind, Professor Lucy Chappell, Professor Richard Emsley, Professor William Hollingworth

  • NIHR130606: What is the clinical and cost-effectiveness of rivastigmine compared with antipsychotic drug treatment for treating psychotic symptoms associated with Parkinson's disease?
    (Dr Dominic ffytche, Institute of Psychiatry, Psychology & Neuroscience, King's College London)
    Committee recommendation: Shortlist

Researcher-Led Stage 1s and Tobacco Call Introduction

19/60: HTA Tobacco Cessation, Control and Harm Reduction Interventions

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Professor Tim Coleman

  • NIHR129438: Smoking cessation in the Emergency Department: a randomised controlled trial
    (Dr Ian Pope, Norfolk and Norwich University Hospitals NHS Foundation Trust)
    Funding Committee recommendation: Shortlist (a show of hands vote took place to assess the support for the proposal: 10 supported, 9 did not, 2 abstained)

19/59: HTA Researcher-led call Primary Research

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Jennifer Logue

  • NIHR130347: Treatment of cardiovascular disease with low dose Rivaroxaban in Advanced Chronic Kidney Disease (TRACK)
    (Professor Patrick Mark, University of Glasgow)
    Funding Committee recommendation: Decline (a show of hands vote took place to assess the support for the proposal: 0 supported, 18 did not)

19/59: HTA Researcher-led call Primary Research

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Jennifer Logue, Dr Kathryn Radford, Dr Susan Jowett, Professor Thomas Pinkney

  • NIHR130487: A randomised controlled trial of a facilitated home-based rehabilitation intervention in patients with heart failure with preserved ejection fraction and their caregivers: the REACH-HFpEF Study
    (Professor Rod Taylor, University of Glasgow)
    Funding Committee recommendation: Shortlist

19/60: HTA Tobacco Cessation, Control and Harm Reduction Interventions

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Jennifer Logue, Dr Susan Jowett, Professor Lucy Chappell, Professor Richard Emsley, Professor Tim Coleman

  • NIHR129735: Health effects of short-term and long-term use of e-cigarettes
    (Professor Peter Hajek, Queen Mary University of London)
    Funding Committee recommendation: Shortlist

19/59: HTA Researcher-led call Primary Research

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Kathryn Radford, Dr Susan Jowett, Professor Alan Montgomery, Professor Hywel Williams, Professor Kapil Sayal

  • NIHR129917: Tranexamic acid for hyper acute spontaneous intracerebral haemorrhage TICH-3
    (Professor Nikola Sprigg, The University of Nottingham)
    Funding Committee recommendation: Shortlist

19/60: HTA Tobacco Cessation, Control and Harm Reduction Interventions

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Jennifer Logue, Professor Hywel Williams, Professor Lucy Chappell, Professor Scott Weich

  • NIHR130218: RAndomised controlled trial of TobaCco Harm rEducTion for people with serious mental illness (RATCHET)
    (Dr Paul Aveyard, University of Oxford)
    Funding Committee recommendation: Decline (a show of hands vote took place to assess the support for the proposal: 3 supported, 12 did not)

19/59: HTA Researcher-led call Primary Research

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Elena Pizzo, Dr Susan Jowett, Professor Alan Montgomery, Professor Lucy Chappell, Professor Thomas Pinkney

  • NIHR129789: COLP Study. Cold coagulation or LLETZ Pre-term birth and miscarriage study
    (Dr Martyn Underwood, Shrewsbury and Telford Hospital NHS Trust)
    Funding Committee recommendation: Decline

19/59: HTA Researcher-led call Primary Research

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Elena Pizzo, Dr Kathryn Radford, Professor Lucy Chappell, Professor Sharon Simpson

  • NIHR130092: Randomised Controlled Trial on Effectiveness of Medication to Manage Sexual Preoccupation in Adult Male Prisoners Convicted of Sexual Offences (TEMMPASO)
    (Dr Artemis Igoumenou, University College London)
    Funding Committee recommendation: Shortlist

19/60: HTA Tobacco Cessation, Control and Harm Reduction Interventions

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Professor Sharon Simpson

Left meeting: Professor Tim Coleman

  • NIHR129780: The ENHANCE-D Study – ENHANCing smoking cEssation interventions in Dentistry
    (Dr Richard Holliday, Northumbria Healthcare NHS Foundation Trust)
    Funding Committee recommendation: Shortlist (a show of hands vote took place to assess the support for the proposal: 13 supported, 7 did not)

19/60: HTA Tobacco Cessation, Control and Harm Reduction Interventions

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Kathryn Radford, Professor Alan Montgomery, Professor Hywel Williams

Left meeting: Scott Weich

  • NIHR130559: Smoking cessation interventions in pregnant women and their predicted long-term health and economic impact in the UK: A systematic review with network meta-analysis and simulation modelling.
    (Dr Laura Webber, HealthLumen)
    Funding Committee recommendation: Decline

19/59: HTA Researcher-led call Primary Research

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Katherine Brown, Professor Lucy Chappell

  • NIHR130507: Best practice in preterm nutritional care: A randomised controlled two-by-two factorial trial of timing of commencement of parenteral nutrition after birth and routine fortification of breast milk in very preterm babies. The SPRUCE trial.
    (Dr Sabita Uthaya, Imperial College London)
    Funding Committee recommendation: Decline

19/59: HTA Researcher-led call Primary Research

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Katherine Brown, Professor Lucy Chappell

  • NIHR129809: Digital CONtraCEption Provision and supporT integrated with usual care compared with usual care alone: a randomised controlled trial of the effects on unplanned pregnancy among sexually active women aged 16-44 in the UK (D-CONCEPT: 24 trial)
    (Professor Caroline Free, London School of Hygiene & Tropical Medicine)
    Funding Committee recommendation: Decline (a show of hands vote took place to assess the support for the proposal: 1 supported, 18 did not)