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HTA Funding Committee Public Minutes 13-14 July 2021

Contents

Meeting

HTA Funding Committee (General)

Day 1 - Tuesday 13th July 2021

Venue

Virtual Meeting via Microsoft Teams

Present members

  • Professor Julia Brown (Chair)
  • Professor Rupert Pearse (Deputy Chair)
  • Professor Andrew Farmer (Programme Director)
  • Dr Ashley Agus
  • Professor Hashim Ahmed
  • Professor Julie Brittenden
  • Professor Matthew Costa
  • Dr Fay Crawford
  • Professor Jo Dumville
  • Professor Caroline Free
  • Professor Simon Gates
  • Professor Kerenza Hood
  • Professor Nick James
  • Professor Asma Khalil
  • Dr Stephanie MacNeill
  • Mr Matthew Moore (Public Committee Member)
  • Professor Mark Peters
  • Professor Craig Ramsay
  • Mrs Amanda Roberts (Public Committee Member)
  • Dr Marta Soares
  • Dr Martin Thomas
  • Associate Professor Jo Thompson-Coon
  • Dr Sara Twaddle

NETSCC, HTA Secretariat

  • Dr Simon Fraser (Consultant Advisor)
  • Laura Bradley (Research Manager)
  • Cristina Lujan Barroso (Research Manager)
  • Karen Williams (Senior Research Manager)
  • Louisa Saunders (Assistant Research Manager)
  • Julie Herring (Administrator)

Apologies           

  • Dr Marc Serfaty
  • Professor Tammi Walker
  • Professor Nick Francis

Observers          

  • Alan Marshall (NETSCC)
  • Dr Emma Small (HCR Wales)
  • Sarah Testori – Clinical Trial Policy Manager (DHSC)
  • Dr Julie McCarroll (HSCNI)
  • Juliana Callaghan (NETSCC)

Quoracy Information     

  • Voting members: 24 Quorum = 16
  • Voting members present on Day 1: 21 (84%)

Stage 2 Applications

20/140: Faecal immunochemical test (FIT) based tools to triage patients in primary care

Chair: Professor Rupert Pearse
Conflicts: Professor Andrew Farmer, Professor Joanna Thompson-Coon
Left meeting: Emma Small (Observer)

NIHR133852: COLOFIT - Optimal use of Faecal Immunochemical Testing for patients with symptoms of possible colorectal cancer.
(Professor Colin Rees, University of Newcastle upon Tyne)
Decision: Programme Oversight Committee to consider fund with changes

HTA Broad Brief Stage 2 Proposals

20/28: Repair and rehabilitation of hand flexor tendon injury

Chair: Professor Rupert Pearse
Conflicts: Professor Andrew Farmer, Professor Hashim Ahmed, Professor Jo Dumville, Professor Julia Brown, Professor Matthew Costa
Left meeting: Nick James

NIHR133582: Prospective randomised controlled trial comparing three splints for finger flexor tendon repairs (FIRST study).
(Mrs Emma Bamford, Derby Hospitals NHS Foundation Trust)
Decision: Programme Oversight Committee to consider fund with changes

NIHR133784: A 2 x 2 factorial randomised trial to determine the clinical and cost effectiveness of repairing flexor digitorum profundus alone and a new rehabilitation regimen versus usual care for treatment of complete zone II flexor tendon injuries: the FLexor repAir and REhabilitation (FLARE) Trial
(Mr Matthew Gardiner, Frimley Health NHS Foundation Trust)
Decision: Programme Oversight Committee to consider fund with changes

HTA Researcher-led (Primary Research) Stage 2 Proposals

20/90: HTA Researcher-led call Primary Research

NIHR133776: Examining the benefit of graduated compression stockings in the Prevention of vEnous Thromboembolism in low-risk Surgical patients: a multicentre cluster randomised controlled trial (PETS Trial)
(Professor Alun Davies, Imperial College London)
Chair: Professor Julia Brown
Conflicts: Professor Craig Ramsay, Professor Hashim Ahmed, Professor Jo Dumville
Arrived meeting: Nick James
Decision: Programme Oversight Committee to consider fund with changes

NIHR133581: Furosemide against Bumetanide for the treatment of recently decompensated heart failure
(Dr David Wilson, Worcestershire Acute Hospitals NHS Trust)
Chair: Professor Julia Brown
Conflicts: Professor Andrew Farmer, Professor Julie Brittenden, Professor Simon Gates
Left meeting: Alan Marshall (Observer)
Decision: Decline

NIHR133467: The clinical benefits and cost-effectiveness and safety of haematopoietic interventions for patients with anaemia following major emergency surgery: a phase IV, multicentre, multi-arm randomised controlled trial: Peri-op Iron and EPO Intervention Study - POP-I
(Professor Iain Moppett, The University of Nottingham)
Chair: Professor Julia Brown
Conflicts: Professor Andrew Farmer, Professor Jo Dumville, Professor Matthew Costa, Professor Rupert Pearse
Decision: Programme Oversight Committee to consider fund with changes

NIHR133719: Staphylococcus aureus Network Adaptive Platform (SNAP) Trial
(Dr Anna Goodman, Guy's and St Thomas' NHS Foundation Trust)
Chair: Professor Rupert Pearse
Conflicts: Professor Andrew Farmer, Professor Jo Dumville, Professor Kerenza Hood
Decision: Programme Oversight Committee to consider fund with changes.

Stage 1 Applications

HTA Broad Brief Stage 1 Proposals

20/109: Shorter vs longer fixed-course antibiotic treatments

NIHR133560: TOPical Glycopeptides vs Usual antibiotics in Neck of femur: TOPGUN
(Professor Ben Ollivere, The University of Nottingham)
Chair: Professor Julia Brown
Conflicts: Professor Andrew Farmer, Professor Rupert Pearse
Left meeting: Caroline Free, Alan Marshall (Observer)
Arrived meeting: Emma Small (Observer), Marta Soares
Decision: Decline

NIHR134867: Cellulitis Optimal Antibiotic Treatment: COAT study
(Professor Nick Francis, University of Southampton)
Chair: Professor Julia Brown
Conflicts: Dr Simon Fraser, Mrs Amanda Roberts, Professor Andrew Farmer, Professor Kerenza Hood
Decision: Shortlist

NIHR134336: Impact of duration of intravenous antibiotic therapy on effectiveness, safety and colonisation by resistant bacteria in culture-negative neonatal sepsis
(Dr Julia Bielicki, St George's, University of London)
Chair: Professor Rupert Pearse
Conflicts: Professor Andrew Farmer
Left meeting: Nick James
Arrived meeting: Caroline Free
Decision: Decline

NIHR134534: Cefalexin for UTIs – Right treatment Length in Young children (the CURLY trial). A multi-centre, pragmatic, randomised trial to determine the optimal duration of cefalexin therapy for the treatment of febrile urinary tract infections in children.
(Dr Stuart Hartshorn, Birmingham Women's and Children's NHS Foundation Trust)
Chair: Professor Rupert Pearse
Conflicts: Mr Matthew Moore, Professor Simon Gates
Decision: Shortlist 

NIHR134582: A multi-arm cluster and individually randomised trial to identify shorter antibiotic durations for common infections in primary care and to guide general practitioners and patients towards implementing best practice (SHORT)
(Dr Victoria Palin, The University of Manchester)
Chair: Professor Julia Brown
Conflicts: Professor Jo Dumville
Arrived meeting: Alan Marshall (Observer)
Left meeting: Marta Soares
Decision: Decline

NIHR134101: A randomised controlled trial of SHORT duration antibiotic thERapy for critically ill patients with sepsis: SHORTER Trial
(Dr Thomas Hellyer, University of Newcastle upon Tyne)
Chair: Professor Rupert Pearse
Conflicts: Professor Hashim Ahmed, Professor Simon Gates, Dr Ashley Agus
Arrived meeting: Marta Soares, Nick James
Decision: Shortlist

NIHR133876: Seven versus Fourteen Days Antibiotics for Patients with Bronchiectasis Requiring Intravenous Antibiotics- SBIVA Study
(Professor Adam Hill, NHS Education for Scotland)
Chair: Professor Rupert Pearse
Conflicts: None
Decision: Shortlist

NIHR133875: SHorter vs Longer CoUrse AnTibiotics – an AdaptivE BaYEsian Design Study (SHUTEYE)
(Honorary Professor Tony Whitehouse, University Hospitals Birmingham NHS Foundation Trust)
Chair: Professor Julia Brown
Conflicts: Professor Simon Gates
Left meeting: Julie McCarroll (Observer)
Decision: Shortlist

NIHR134854: DURATION OF ANTIBIOTIC TREATMENT IN URINARY TRACT INFECTION (DurATIon-UTI Trial) Impact of duration of antibiotic therapy on effectiveness, safety and selection of antibiotic resistance in adult women with urinary tract infections (UTI): a randomised controlled trial.
(Associate Professor Gail Hayward, University of Oxford)
Chair: Professor Rupert Pearse
Conflicts: Dr Marta Soares, Professor Andrew Farmer, Professor Kerenza Hood
Decision: Shortlist 

HTA Researcher-led (Primary research) Stage 1 Proposal

21/01: HTA Researcher-led call Primary Research

NIHR133611: Inpatient graduated compression stocking use as an adjunct to extended duration pharmacoprophylaxis for venous thromboembolism prevention – a multi-centre randomised controlled trial
(Professor Alun Davies, Imperial College London)
Chair: Professor Rupert Pearse
Conflicts: Professor Craig Ramsay, Professor Hashim Ahmed, Professor Jo Dumville
Left meeting: Alan Marshall (Observer)
Decision: Decline 

Day 2 - Wednesday 14th July 2021

Venue

Virtual Meeting via Microsoft Teams

Present members

  • Professor Julia Brown (Chair)
  • Professor Rupert Pearse (Deputy Chair)
  • Professor Andrew Farmer (Programme Director)
  • Dr Ashley Agus
  • Professor Hashim Ahmed
  • Professor Julie Brittenden
  • Dr Fay Crawford
  • Professor Jo Dumville
  • Professor Nick Francis
  • Professor Caroline Free
  • Professor Simon Gates
  • Professor Kerenza Hood
  • Professor Nick James
  • Professor Asma Khalil
  • Dr Stephanie MacNeill
  • Mr Matthew Moore (Public Committee Member)
  • Professor Mark Peters
  • Professor Craig Ramsay
  • Mrs Amanda Roberts (Public Committee Member)
  • Dr Marta Soares
  • Dr Martin Thomas
  • Associate Professor Jo Thompson-Coon
  • Dr Sara Twaddle

NETSCC, HTA Secretariat

  • Dr Simon Fraser (Consultant Advisor).
  • Laura Bradley (Research manager)
  • Cristina Lujan Barroso (Research manager)
  • Karen Williams (Senior Research Manager)
  • Louisa Saunders (Assistant Research Manager)
  • Julie Herring (Administrator)

Apologies           

  • Dr Marc Serfaty
  • Professor Tammi Walker
  • Professor Matthew Costa

Observers          

  • Dr Emma Small (HC Wales )
  • Sarah Testori (DHSC) – Clinical Trial Policy Manager
  • Dr Julie McCarroll (HSCNI)

Quoracy Information     

  • Voting members: 24 Quorum = 16
  • Voting members present on Day 1: 21 (84%)

HTA Researcher-Led Stage 1 (PR) Continued

21/01: HTA Researcher-led call Primary Research

NIHR134248: RecommenD iT: a randomised trial on timing of Recommencement of Direct oral anticoagulants in Traumatic intracranial haemorrhage.
(Miss Catherine McMahon, The Walton Centre NHS Foundation Trust)
Chair: Professor Julia Brown
Conflicts: Professor Joanna Thompson-Coon
Decision: Decline 

NIHR134886: Early versus Later AntiPlatelet uSE after Chronic Subdural Haematoma (ELAPSE-CSDH)
(Mr Paul Brennan, The University of Edinburgh)
Chair: Professor Julia Brown
Conflicts: None
Decision: Decline 

NIHR134034: Azithromycin at Caesarean Section to prevent Maternal Infection: a Randomised Controlled Trial
(Dr Victoria Hodgetts Morton, University of Birmingham)
Chair: Professor Rupert Pearse
Conflicts: Professor Simon Gates
Decision: Decline

NIHR134379: A randomised controlled trial assessing the clinical and cost effectiveness of compression HOSiery to Treat varicose vein Symptoms - the HOSTS study
(Professor Alun Davies, Imperial College London)
Chair: Professor Rupert Pearse
Conflicts: Dr Marta Soares, Professor Andrew Farmer, Professor Caroline Free, Professor Craig Ramsay, Professor Hashim Ahmed, Professor Jo Dumville, Professor Nick Francis
Decision: Decline 

NIHR134746: Perineural Local Anaesthetic Catheter aftEr Major lowEr limb amputatioN Trial (PLACEMENT)
(Mr David Bosanquet, Aneurin Bevan University Health Board)
Chair: Professor Julia Brown
Conflicts: Professor Kerenza Hood, Professor Nick Francis
Decision: Shortlist

NIHR134660: Randomised Evaluation of Sodium Dialysate Levels on Vascular Events (RESOLVE).
(Professor David Wheeler, University College London)
Chair: Professor Julia Brown
Conflicts: Dr Martin Thomas, Dr Simon Fraser, Dr Stephanie MacNeill
Decision: Shortlist 

NIHR133889: Palliative Long-term Abdominal Drains Versus Repeated Drainage in Untreatable Ascites Due to Advanced Cirrhosis: A Randomised Controlled Trial
(Professor Sumita Verma, University of Sussex)
Chair: Professor Julia Brown
Conflicts: Dr Simon Fraser
Decision: Shortlist 

NIHR134463: Investigating the efficacy of varenicline to aid gradual smoking cessation: a randomised controlled superiority trial (the VERSA trial)
(Dr Nicola Lindson, University of Oxford)
Chair: Professor Rupert Pearse
Conflicts: Dr Marta Soares, Professor Andrew Farmer, Professor Jo Dumville
Decision: Decline

NIHR134431: Radioactive Iodine: Long-Term Safety and Cost-Effectiveness for the Treatment of Hyperthyroidism
(Dr Diarmuid Coughlan, University of Newcastle upon Tyne)
Chair: Professor Rupert Pearse
Conflicts: Professor Craig Ramsay, Professor Hashim Ahmed
Decision: Decline 

HTA Researcher-led (ES) Stage 1 Proposals

21/02: HTA Researcher-led call Evidence Synthesis

NIHR134910: Cartilage repair in the ankle.
(Professor Norman Waugh, University of Warwick)
Chair: Professor Julia Brown
Conflicts: Dr Martin Thomas
Left meeting: Julie McCarroll (Observer)
Decision: Decline

NIHR134658: Identifying the effective components of weight management strategies for postpartum women: a stakeholder informed systematic review and co-designed toolkit
(Dr Amanda Rodrigues Amorim Adegboye, Coventry University)
Chair: Professor Rupert Pearse
Conflicts: None
Decision: Decline

NIHR134472: Ultrasound and magnetic resonance imaging for hepatocellular cancer surveillance in the UK
(Associate Professor James Franklin, Bournemouth University)
Chair: Professor Julia Brown
Conflicts: Dr Simon Fraser, Professor Joanna Thompson-Coon, Dr Stephanie MacNeill, Professor Hashim Ahmed
Decision: Decline 

NIHR134670: The benefits, harms and costs of surveillance for hepatocellular carcinoma in people with cirrhosis: synthesis of observational and diagnostic test accuracy data and cost–utility analysis
(Mr Gabriel Rogers, The University of Manchester)
Chair: Professor Julia Brown
Conflicts: 
None
Decision:
Shortlist

NIHR134862: Physical rehabilitation for older people in care homes:  a systematic review and network meta-analysis
(Dr Thomas Crocker, Bradford Teaching Hospitals NHS Foundation Trust)
Chair: Professor Rupert Pearse
Conflicts: Dr Martin Thomas, Dr Simon Fraser, Professor Julia Brown
Left meeting: Sarah Testori (Observer)
Decision: Decline 

NIHR134407: An evidence synthesis of interventions to prevent maternal suicidality in women during the perinatal period: a systematic review, meta-analysis and meta-synthesis of quantitative and qualitative studies evaluating their clinical effectiveness, the cost-effectiveness, safety and acceptability
(Dr Anja Wittkowski, The University of Manchester)
Chair: Professor Rupert Pearse
Conflicts: None
Arrived meeting: Julie McCarroll (Observer)
Decision: Decline

NIHR134786: The effectiveness of antibiotic therapies for pelvic inflammatory disease: a systematic review, core outcome set development and network meta-analysis
(Dr Ruaraidh Hill, University of Liverpool)
Chair: Professor Julia Brown
Conflicts: Professor Kerenza Hood, Professor Simon Gates
Decision: Shortlist