Day 1 - Tuesday 14 March 2023
Venue
Microsoft Teams
Present members
- Julia Brown (Chair)
- Mark Peters (Deputy Chair)
- Andrew Farmer (Programme Director)
- David Green (Public Committee Member)
- Ashley Agus
- Hashim Ahmed
- Jo Dumville
- Nick Francis
- Caroline Free
- Simon Gates
- David Keene
- Stephanie MacNeill
- Marta Soares
- Joanna Thompson-Coon
- Laura Coates (Committee Member Development Scheme Participant)
- Khalida Ismail
- Hema Mistry
- Dawn-Marie Walker
- Athanasios Saratzis
- Matthew Moore (Public Committee Member)
- Stuart McIntosh
- Ben Carter
- Abdullah Pandor
- Thomas Hellyer (Committee Member Development Scheme Participant)
- Garry Barton
- Victoria Goodwin
- Joyce Yeung
- Sarah Markham (Public Committee Member)
Secretariat
- Vicky Taylor (Assistant Director)
- Jason Horsley (Consultant Advisor)
- Cristina Lujan Barroso (Research Manager)
- Kathy Tier (Research Manager)
- Daniel Housego (Research Manager)
- Karen Williams (Senior Research Manager)
- Louisa Saunders (Assistant Research Manager)
Apologies
- Jugdeep Dhesi
- David Harrison
Observers
- Martin Dixon
- Anto John
- Benaya Kaunda
Quoracy information
- Voting members: 29 (Emergency Quoracy = 19 = 66%)
- Voting members present on Day 1: 27 (93%)
Stage 2 Applications
22/37 Non-pharmacological interventions for fatigue management in adults with long-term health conditions
NIHR154660 - Effectiveness of Interventions For Fatigue in Long term conditions (EIFFEL) (Christopher Burton)
Chair: Julia Brown
Conflicts: Joanna Thompson-Coon, David Keene, Abdullah Pandor, Thomas Hellyer
Decision: Programme Oversight Committee to consider fund with changes
22/4 NIHR James Lind Alliance Priority Setting Partnerships Rolling Call (HTA Programme: Jan 22 - May 22)
NIHR153258 - DEBI: clinical and cost-effectiveness of desogestrel versus the combined oral contraceptive pill for problem bleeding on the etonogestrel implant (Kate Walker)
Chair: Julia Brown
Conflicts: Caroline Free, Hema Mistry
Decision: Stage 2 resubmission
22/12 The development and evaluation of predictive algorithms using Artificial Intelligence (AI) - HTA
NIHR153364 - StratCare Trial 2: Evaluating the clinical and cost-effectiveness of AI-driven stratified care for depression (Jaime Delgadillo)
Chair: Julia Brown
Conflicts: Andrew Farmer, Jo Dumville, Abdullah Pandor
Arrived at the meeting: Matthew Moore
Left the meeting: Sarah Markham
Decision: Programme Oversight Committee to consider fund with changes
22/61 HTA Researcher-led call Primary Research
NIHR155294 - Inpatient GRAduated Compression stocking use as an adjunct to Extended duration pharmacoprophylaxis for venous thromboembolism prevention – the GRACE multi-centre randomised controlled trial (Alun Davies)
Chair: Julia Brown
Conflicts: Jo Dumville, Athanasios Saratzis, Abdullah Pandor, Hashim Ahmed, David Keene, Laura Coates, Andrew Farmer, Simon Gates, Joyce Yeung
Arrived at the meeting: Janet Diffin (observer)
Decision: Programme Oversight Committee to consider fund with changes
22/64 NIHR James Lind Alliance Priority Setting Partnerships Rolling Call (HTA Programme: May 22 - Aug 22)
NIHR154252 - Randomised trial examining clinical and cost effectiveness of three antithrombotic regimens following endovascular lower limb revascularisation for chronic limb threatening ischaemia: CLARITY (CLopidogrel, Aspirin and RIvaroxaban after revascularIsation with angioplasTY) (Christopher Twine)
Chair: Mark Peters
Conflicts: Jo Dumville, Nick Francis, Athanasios Saratzis, Joyce Yeung, Hashim Ahmed, Julia Brown
Arrived at the meeting: Martin Dixon (observer)
Decision: Programme Oversight Committee to consider fund with changes
NIHR155220 - A double-blind randomised placebo-controlled trial to assess the effectiveness and cost-effectiveness of oral Corticosteroids in patients witH fibrOtic hypeRsensitivity pneUmonitiS (CHORUS) (Michael Gibbons)
Chair: Julia Brown
Conflicts: Ashley Agus. Victoria Goodwin, David Keene. Joanna Thompson-Coon, Athanasios Saratzis, Garry Barton, Thomas Hellyer
Arrived at the meeting: Sarah Markham
Left the meeting: Matthew Moore
Decision: Stage 2 resubmission
22/3 NIHR NICE Rolling Call (HTA Programme: Jan 22 - May 22)
NIHR152845 - SORTED Surgery Or Rehabilitation for Traumatic shouldEr Dislocations (Stephen Gwilym)
Chair: Julia Brown
Conflicts: David Keene, Hema Mistry, Andrew Farmer, Stephanie MacNeill, Laura Coates, Joyce Yeung, Simon Gates
Left the meeting: Stuart McIntosh
Decision: Stage 2 resubmission
NIHR152516 - ICS-RECODE: Predictors of treatment REsponse to inhaled corticosteroids (ICS) in COPD: randomised COntrolled trials individual participant Data re-Evaluation. (Alexander Mathioudakis)
Chair: Julia Brown
Conflicts: Jo Dumville, Abdullah Pandor
Decision: Programme Oversight Committee to consider fund with changes
Stage 1 Applications
22/99 Clinical prediction models for early-onset neonatal infection
Chair: Julia Brown
Conflicts: Ashley Agus, Khalida Ismail, Hema Mistry, Andrew Farmer, Simon Gates, Mark Peters, Joyce Yeung
Arrived at the meeting: Marta Soares
NIHR154983 - Clinical pRediction model for eArlY-onset neOnatal iNfection: The CRAYON study. A cluster randomised trial and validation study of the Sepsis Risk Calculator with health economic and acceptability evaluations. (Sabita Uthaya)
Decision: Shortlist
NIHR156385 - Predicting Early Onset Neonatal Infection (PEONI): a multi centre, open label, superiority, cluster randomised controlled trial (Shalini Ojha)
Decision: Decline
22/97 Early detection of liver disease
Chair: Caroline Free
Conflicts: Nick Francis, Joanna Thompson-Coon, Victoria Goodwin, Simon Gates, David Keene, Stephanie MacNeill, Mark Peters, Andrew Farmer, Julia Brown, Hema Mistry, Athanasios Saratzis
NIHR155989 - DETECTOR: A cluster randomized trial of early detection of cirrhosis in primary care (John Dillon)
Decision: Decline Return to POC
NIHR157453 - Selecting people at risk of chronic liver disease in primary care for referral to secondary care - SEARCH (Ian Rowe)
Decision: Decline Return to POC
22/96 Urine sampling in children
NIHR156005 - Determining the feasibility of randomising children and young people to invasive and non-invasive urine sampling techniques. (Thomas Waterfield)
Chair: Julia Brown
Conflicts: Hema Mistry, Ashley Agus, Mark Peters
Left the meeting: Matthew Moore, Marta Soares, Martin Dixon (observer)
Decision: Stage 1 resubmission
22/98 Low-dose computed tomography for the diagnosis of lung cancer in symptomatic patients seen in primary care
Chair: Mark Peters
Conflicts: Julia Brown, David Keene, Joanna Thompson-Coon, Joyce Yeung, Andrew Farmer, Nick Francis
Arrived at the meeting: Matthew Moore
NIHR155952 - Methods of Early Detection of Lung cancEr in PrimarY Care (MEDLEY) (Matthew Callister)
Decision: Shortlist
NIHR157368 - SHOuld CT scans replace CXRs for Primary Care ChEst Imaging. The HOPE trial (Fergus Gleeson)
Decision: Shortlist
22/95 Chronic kidney disease education for patients, families and carers
Chair: Mark Peters
Conflicts: Abdullah Pandor, Athanasios Saratzis, Julia Brown, David Keene, Joanna Thompson-Coon, Hema Mistry, Victoria Goodwin
Arrived at the meeting: Martin Dixon (observer)
NIHR156249 - Interventions delivering chronic kidney disease information and education: evidence mapping, realist synthesis, and evaluation of clinical- and cost-effectiveness (Thomas Wilkinson)
Decision: Decline
NIHR157760 - Does current provision of information and education to patients, families and carers in the UK with CKD Stages 2-4 align with evidence on effectiveness and cost-effectiveness, and what factors tend to increase or decrease its use? (Peter Knapp)
Decision: Shortlist
NIHR157908 - Mixed Method Evidence Synthesis for Equity: to identify inclusive education and information interventions for all people managing early-stage chronic kidney disease (Paula Ormandy)
Decision: Shortlist
22/100 Pain management for children and young people
NIHR157424 - The Analgesia Versus Intravenous Sedation for Fracture Reduction in Children (AVIS) Trial: A multi-centre prospective randomised trial comparing intravenous sedation with short-acting analgesia for closed reduction of paediatric fractures in the Emergency Department. (David Metcalfe)
Chair: Julia Brown
Conflicts: David Keene, Andrew Farmer, Laura Coates, Athanasios Saratzis
Decision: Decline
22/101 Management of bone metastasis and skeletal related events (SREs) in patients with advanced cancer
NIHR155305 - A randomised phase III trial evaluating the efficacy and cost-effectiveness of stereotactic radiotherapy compared with conventional radiotherapy for reducing pain associated with spinal metastases (SENSE) (Fay Cafferty)
Chair: Mark Peters
Conflicts: Hashim Ahmed, Julia Brown
Left the meeting: Matthew Moore
Decision: Decline
22/113 HTA Programme Researcher-led call Evidence Synthesis
NIHR156203 - Confirming the placement of nasogastric tubes: a systematic review and economic evaluation (Elizabeth Lightbody)
Chair: Julia Brown
Conflicts: Jo Dumville
Arrived at the meeting: Matthew Moore
Decision: Shortlist
NIHR156881 - Expanding the eligibility criteria for a no-biopsy diagnosis for coeliac disease in adults and children: Individual participant data review and cost-effectiveness analysis. (Penny Whiting)
Chair: Julia Brown
Conflicts: Jo Dumville, Athanasios Saratzis, Nick Francis, Stephanie MacNeill, Abdullah Pandor
Left the meeting: Sarah Markham
Decision: Shortlist