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HTA Funding Committee Public Minutes 18-19 May 2021

Contents

Meeting

HTA Funding Committee (Commissioning)

Day 1 - Tuesday 18th May 2021

Venue

Virtual Meeting via Microsoft Teams

Present members

Professor Marian Knight (Chair)
Professor Catherine Hewitt (Deputy Chair)
Professor Andrew Farmer (Programme Director)
Professor Joy Adamson
Mr Roshan Bootun
Professor Monica Busse
Mr Paul Charlton (Public Committee Member)
Dr Rui Duarte
Dr Emilio Fernandez-Egea
Dr Pollyanna Hardy
Professor Angela Hassiotis
Mr Rakesh Heer
Ms Debby Lennard (Public Committee Member)
Professor Nick Maskell
Associate Professor Antonieta Medina-Lara
Professor Jane Nixon
Professor Daniel Perry
Dr Greta Rait
Professor Rebecca Reynolds
Professor Chris Rogers
Professor Jonathan Ross
Professor Andrew Shennan
Professor Sobha Sivaprasad
Dr Beth Stuart
Dr Chris Sutton
Associate Professor Lyvonne Tume
Professor Galina Velikova
Professor Nefyn Williams

NETSCC, HTA Secretariat

Dr Nick Hicks (Consultant Advisor)
Steph Garfield-Birkbeck (Head of the HTA Programme)
Vicky Taylor (Assistant Director Application & Funding and Wales)
Kathy Tier (Research Manager)
Laura Bradley (Research Manager)
Hebe Sims (Assistant Research Manager)
Louisa Saunders (Assistant Research Manager)

Apologies

Professor Saul Faust

Observers

Ms Julie McCarroll (HSC Northern Ireland - DA representative for Northern Ireland)
Ms Helen Adams (DHSC)
Ms Emma Small (HCRW – DA representative for Wales)
Janet Clapton – new ARM for HTA NETSCC

Quoracy Information

Voting members: 27 Quorum = 18
Voting members present on Day 1: 26 (96%)

 

Commissioned Stage 2 applications shortlisted at January 2021 Committee meeting

20/96 Partial vs radical nephrectomy for clinically localised renal cell carcinoma

Chair: Professor Marian Knight
Conflicts: Professor Greta Rait, Professor Nick Maskell, Professor Rakesh Heer
Left meeting: Julie McCarroll (observer)

NIHR133322: A multi-centre, pragmatic, randomized controlled, parallel-group, non-inferiority trial to compare the efficacy of PaRtial versus tOtal nePhrectomy for clinically localisEd moderately to highly complex renal cancer (PROPER) trial
(Associate Professor Maxine Tran, University College London)
Decision: Decline

NIHR133561: The PARTIAL study – a randomised trial of the clinical and cost effectiveness of PARTIAL vs radical nephrectomy for clinically localised renal cell carcinoma
(Professor Naeem Soomro, The Newcastle Upon Tyne Hospitals NHS Foundation Trust)
Decision: Programme Oversight Committee to consider fund with changes

20/73 Surgery for endometrioma in women undergoing IVF

Chair: Professor Catherine Hewitt
Conflicts: Dr Christopher Sutton, Ms Pollyanna Hardy, Professor Beth Stuart, Professor Greta Rait, Professor Jonathan Ross, Professor Rakesh Heer, Professor Rebecca Reynolds
Arrived at meeting: Julie McCarroll (observer)

NIHR133621: Surgery for endometrioma in women undergoing IVF
(Professor Abha Maheshwari, NHS Grampian)
Decision: Decline Return to POC

20/76 Reverse vs conventional shoulder replacement for adults with osteoarthritis

Chair: Dr Nicholas Hicks
Conflicts: Dr Christopher Sutton, Professor Andrew Farmer, Professor Antonieta Medina-Lara, Professor Catherine Hewitt, Professor Joy Adamson, Professor Marian Knight
Left meeting: Helen Adams (observer)

NIHR133337: Conventional versus reverse total shoulder arthroplasty trial (ConVeRTS)
(Associate Professor David Ellard, University of Warwick)
Decision: Decline

NIHR133418: Reverse or Anatomical (replacement) for Painful Shoulder Osteoarthritis: Differences between Interventions. Acronym; RAPSODI
(Professor Ian Trail, Wrightington, Wigan & Leigh NHS Foundation Trust)
Decision: Programme Oversight Committee to consider fund with changes

20/75: Conservative management of primary spontaneous pneumothorax

Chair: Professor Catherine Hewitt
Conflicts: Professor Andrew Farmer, Professor Chris Rogers, Professor Marian Knight, Professor Nick Maskell

NIHR133653: “CONservative versus Standard carE for primary spontaneous PneumoThorax” (CONSEPT)
(Professor Nick Maskell, University of Bristol)
Decision: Programme Oversight Committee to consider fund with changes

20/72 Oxybutynin for the treatment of vasomotor symptoms associated with menopause

Chair: Professor Catherine Hewitt
Conflicts: Professor Jonathan Ross, Professor Marian Knight
Arrived at meeting: Helen Adams (observer)

NIHR133461: Oxybutynin or venlafaxine for hot flushes in women who cannot or choose not to use hormone replacement therapy: randomised trial and economic evaluation (the BLUSH trial)
(Dr Melanie Davies, University College London Hospitals NHS Foundation Trust)
Decision: Programme Oversight Committee to consider fund with changes

20/22 Rectus Sheath Blockade in Emergency Laparotomy

Chair: Professor Marian Knight
Conflicts: Dr Rui Duarte, Ms Pollyanna Hardy, Professor Chris Rogers, Professor Jonathan Ross, Professor Monica Busse, Professor Nick Maskell

NIHR133554: CAMELOT - Continuous rectus sheath Analgesia in eMErgency LaparOTomy Multi-centre, randomised sham-controlled trial of rectus sheath catheter-delivered local anaesthetic infusion compared with usual care in patients undergoing emergency bowel surgery
(Dr Mark Edwards, University Hospital Southampton NHS Foundation Trust)
Decision: Programme Oversight Committee to consider straight fund

NIHR133625: RELAY Trial (Rectus sheath catheters in Emergency LAparotomY). A multicentre, open label, pragmatic, two arm, parallel group, randomised controlled trial with an internal pilot and economic evaluation.
(Dr Ciro Morgese, University Hospitals Birmingham NHS Foundation Trust)
Decision: Decline

Commissioning Stage 1 applications – received from March call close

20/127 Occupational advice initiated prior to planned surgery for lower limb joint replacement

Chair: Professor Marian Knight
Conflicts: Dr Christopher Sutton, Professor Catherine Hewitt, Professor Chris Rogers, Professor Greta Rait, Professor Jonathan Ross, Professor Joy Adamson, Professor Monica Busse, Professor Nick Maskell, Professor Nefyn Williams

NIHR133713: Occupational advice initiated prior to planned surgery for lower limb joint replacement: the ORCHID trial
(Associate Professor Vikki Wylde, University of Bristol)
Decision: Shortlist

NIHR133880: Occupational support for Patients undergoing Arthroplasty of the Lower limb trial (OPAL2)
(Mr Paul Baker, South Tees Hospitals NHS Foundation Trust)
Decision: Shortlist

20/77 Treatment of recurrent patella dislocation

Chair: Professor Catherine Hewitt
Conflicts: Dr Christopher Sutton, Professor Andrew Farmer, Professor Chris Rogers, Professor Daniel Perry, Professor Marian Knight, Professor Monica Busse, Professor Nick Maskell
Left meeting: Rebecca Reynolds, Julie McCarroll (observer)

NIHR134398: REcurrent Patellar dislocation: Personalised therapy or OpeRative Treatment? (REPPORT)
(Associate Professor Andrew Metcalfe, University of Warwick)
Decision: Shortlist

20/131 Corticosteroid induction regimens for children and young people with juvenile idiopathic arthritis

Chair: Professor Catherine Hewitt
Conflicts: Professor Andrew Farmer, Professor Daniel Perry, Professor Monica Busse, Professor Nefyn Williams
Arrived at meeting: Rebecca Reynolds
Left meeting: Emilio Fernandez-Egea

NIHR134350: Steroid TreAtment TRial in JIA (STAR-JIA): a randomised trial to compare effectiveness, safety and cost-effectiveness of oral versus intravenous corticosteroid induction regimens for children and young people with juvenile idiopathic arthritis
(Dr Clare Pain, Alder Hey Children's NHS Foundation Trust)
Decision: Shortlist

20/126 Imaging in paediatric osteomyelitis

Chair: Professor Catherine Hewitt
Conflicts: Dr Rui Duarte, Ms Pollyanna Hardy, Professor Andrew Farmer, Professor Daniel Perry, Professor Marian Knight
Arrived meeting: Helen Adams (Observer)

NIHR134125: Imaging in Paediatric Osteomyelitis (the PICBONE study): a multi-centre cohort study to understand the role of MRI and ultrasound in the diagnosis of acute haematogenous osteomyelitis in children.(Mr Tim Theologis, Oxford University Hospitals NHS Trust)
Decision: Shortlist

NIHR134270: INFORM study – INvestigation oF Osteomyelitis Radiology Management
(Associate Professor Owen Arthurs, Great Ormond Street Hospital for Children NHS Foundation Trust)
Decision: Shortlist

Day 2 - Wednesday 19th May 2021

Venue

Virtual Meeting via Microsoft Teams

Present members

Professor Marian Knight (Chair)
Professor Catherine Hewitt (Deputy Chair)
Professor Andrew Farmer (Programme Director)
Professor Joy Adamson
Mr Roshan Bootun
Professor Monica Busse
Mr Paul Charlton (Public Committee Member)
Dr Rui Duarte
Dr Emilio Fernandez-Egea
Dr Pollyanna Hardy
Mr Rakesh Heer
Ms Debby Lennard (Public Committee Member)
Professor Nick Maskell
Associate Professor Antonieta Medina-Lara
Professor Jane Nixon
Professor Daniel Perry
Dr Greta Rait
Professor Rebecca Reynolds
Professor Chris Rogers
Professor Jonathan Ross
Professor Andrew Shennan
Professor Sobha Sivaprasad
Dr Beth Stuart
Dr Chris Sutton
Associate Professor Lyvonne Tume
Professor Galina Velikova
Professor Nefyn Williams

NETSCC, HTA Secretariat

Dr Nick Hicks (Consultant Advisor)
Steph Garfield-Birkbeck (Head of the HTA Programme)
Vicky Taylor (Assistant Director Application & Funding and Wales)
Kathy Tier (Research Manager)
Laura Bradley (Research Manager)
Hebe Sims (Assistant Research Manager)
Louisa Saunders (Assistant Research Manager)

Apologies

Professor Saul Faust
Professor Angela Hassiotis

Observers

Ms Julie McCarroll (HSC Northern Ireland - DA representative for Northern Ireland)
Ms Helen Adams (DHSC)
Ms Emma Small (HCRW – DA representative for Wales)
Janet Clapton – new ARM for HTA NETSCC

Quoracy Information

Voting members: 27 Quorum = 18
Voting members present on Day 2: 25 (72%)

 

Commissioning Stage 1 applications – received from March call close continued

20/133 Pre-operative exclusive enteral nutrition for Crohn's disease

Chair: Professor Marian Knight
Conflicts: Dr Rui Duarte, Ms Pollyanna Hardy, Professor Jonathan Ross, Professor Nefyn Williams

NIHR133657: Optimisation before Crohn’s surgery using Exclusive enteral Nutrition (OCEaN study)
(Dr Rachel Cooney, University Hospitals Birmingham NHS Foundation Trust)
Decision: Shortlist

NIHR134304: Title: A multi-centre randomised controlled trial of exclusive enteral nutrition for 4 weeks compared with standard care in preoperative Crohn's disease
Short Title: Preoperative enteral nutrition in Crohn’s disease (POETIC)
(Dr Miranda Lomer, Guy's and St Thomas' NHS Foundation Trust)
Decision: Decline


20/130 Intensive Interaction for children and young people with profound and multiple learning disabilities

Chair: Professor Catherine Hewitt
Conflicts: Professor Andrew Farmer, Professor Angela Hassiotis, Professor Marian Knight, Professor Monica Busse
Left meeting: Mr Rakesh Heer

NIHR134067: A cluster Randomised Controlled Trial of Intensive Interaction plus standard practice vs standard practice alone for children with PMLD: Communication Skills Intensive Interaction trial (CoSII)
(Dr Rachel McNamara, Cardiff University)
Decision: Decline Return to POC

20/134 Psychological intervention for treatment resistant generalised anxiety disorder in older adults

Chair: Professor Marian Knight
Conflicts: Professor Angela Hassiotis, Professor Catherine Hewitt, Professor Greta Rait

NIHR134141: A randomised CONtrolled trial of Tailored Acceptance and Commitment Therapy for older people with treatment resistant Generalised Anxiety Disorder (CONTACT-GAD)
(Dr Rebecca Gould, University College London)
Decision: Shortlist

20/110 Prophylactic antibiotics in chronic obstructive pulmonary disease

Chair: Professor Marian Knight
Conflicts: Dr Rui Duarte, Ms Pollyanna Hardy, Professor Andrew Farmer, Professor Beth Stuart, Professor Monica Busse, Professor Nefyn Williams, Professor Rakesh Heer

NIHR133492: 1. De-Escalating COPD Long term Antibiotic Macrolide therapy (DECLAMPER)- Pragmatic non infEriority pragmatic non-inferiority Randomised controlled trial with internal pilot and cost-effectiveness analysis
(Professor Anthony De-Soyza, University of Newcastle upon Tyne)
Decision: Shortlist

NIHR133892: Deprescribing Prophylactic Antibiotics in COPD: A non-inferiority randomised controlled trial in primary and secondary care (DELTA COPD)
(Dr Shamil Haroon, University of Birmingham)
Decision: Decline

NIHR134446: DIScontinuation of prophylactic antibiotics for Chronic obstructive pulmonary disease ExaceRbatioNs (The DISCERN Trial)
(Dr David Gillespie, Cardiff University)
Decision: Decline

NIHR134464: Optimising azithromycin prevention treatment in COPD to reduce exacerbations (OPACE)
(Professor Ian Wilkinson, University of Cambridge)
Decision: Shortlist

20/129 Routine measurement of gastric residual volume in neonatal critical care

Chair: Professor Catherine Hewitt
Conflicts: Dr Lyvonne Tume, Dr Rui Duarte, Ms Debby Lennard, Ms Pollyanna Hardy, Professor Andrew Farmer, Professor Beth Stuart, Professor Daniel Perry, Professor Marian Knight, Professor Nefyn Williams
Arrived at meeting: Professor Rakesh Heer

NIHR134216: The neoGASTRIC trial: Avoiding routine gastric residual volume measurement in neonatal critical care, a multi-centre, randomised controlled trial
(Dr Chris Gale, Imperial College London)
Decision: Shortlist

20/128 Routine measurement of gastric residual volume in paediatric critical care

Chair: Professor Catherine Hewitt
Conflicts: Dr Lyvonne Tume, Dr Rui Duarte, Professor Marian Knight, Professor Nefyn Williams
NIHR133835: A randomised controlled trial of no routine gastric residual monitoring to guide enteral feeding in paediatric intensive care units: the GASTRIC-PICU trial
(Dr Lyvonne Tume, University of Salford)
Decision: Shortlist

20/132 Sexual health promotion in people with severe mental illness

Chair: Professor Marian Knight
Conflicts: Dr Christopher Sutton, Professor Catherine Hewitt, Professor Greta Rait, Professor Jane Nixon, Professor Joy Adamson
NIHR133865: MORE RESPECT: A Randomised controlled trial of a sexual health promotion intervention for people with severe mental illness delivered in community mental health settings
(Professor Elizabeth Hughes, University of Leeds)
Decision: Shortlist