Day 1: 7 November 2023
Venue
Virtual via Microsoft Teams
Present members
Julia Brown (Chair)
Mark Peters (Deputy Chair)
Andrew Farmer (Programme Director)
Thomas Hellyer (Committee Member Development Scheme Participant)
Marta Soares
Stephanie MacNeill
Simon Gates
Ben Carter
Athanasios Saratzis
Hema Mistry
Mohamed Abdel-Fattah
David Harrison
Ashley Agus
David Keene
Garry Barton
David Green (Public Committee Member)
Khalida Ismail
Nick Francis
Victoria Goodwin
Joanna Thompson-Coon
Matthew Moore (Public Committee Member)
Dawn-Marie Walker
Sarah Markham (Public Committee Member)
Jugdeep Dhesi
Caroline Free
Michelle Collinson
Anthony Kendrick
Richard Riley
Secretariat
James Morris (Consultant Advisor)
Maria Hassard (Assistant Director)
Helen Payne (Senior Research Manager)
Anna Cutler (Senior Research Manager)
Daniel Housego (Research Manager)
Louisa Saunders (Assistant Research Manager)
Apologies
Abdullah Pandor
Jo Dumville
Hashim Ahmed
Stuart McIntosh
Joyce Yeung
Observers
Catherine Hewitt
Rachel Stockley - Incoming Committee Member Development Scheme Participant
Harm Van Marwijk
Isla Henderson (Monitoring Research Manager)
Quoracy information
- Voting members: 32
- Quorum = 21 = 66%
- Emergency Quorum = 16 = 50%
- Voting members present on Day 1: 27
Stage 2 applications
22/113 HTA Programme Researcher-led call Evidence Synthesis
NIHR156881 - Expanding the eligibility criteria for a no-biopsy diagnosis for coeliac disease in adults and children: Individual participant data review and cost-effectiveness analysis.
- Chair: Julia Brown
- Conflicts: Richard Riley, Nick Francis, Stephanie MacNeill, Anthony Kendrick, Athanasios Saratzis
- Left the meeting: Matthew Moore
- Decision: Programme Oversight Committee to consider fund with changes
23/1 HTA Programme Researcher-led (Primary Research) call
NIHR158052 - Long-term outcomes of the Treatment of Advanced Glaucoma Study (TAGS): A multicentre randomised controlled trial comparing primary medical treatment with primary trabeculectomy for people with newly diagnosed advanced glaucoma
- Chair: Julia Brown
- Conflicts: Athanasios Saratzis, Ashley Agus, Mohamed Abdel-Fattah
- Arrived at the meeting: Matthew Moore
- Decision: Programme Oversight Committee to consider fund with changes
NIHR159223 - The clinical and cost effectiveness of tight versus less tight glucose control around the time of birth in pregnancies complicated by gestational diabetes: the GILD trial
- Chair: Mark Peters
- Conflicts: Athanasios Saratzis, Hema Mistry, Garry Barton, Andrew Farmer, Khalida Ismail
- Decision: Programme Oversight Committee to consider fund with changes
23/3 NIHR NICE Rolling Call (HTA Programme: Jan 23 – May 23)
NIHR159321 - DIRECT: Delivery and Implementation of a Randomised Cluster Crossover Trial on Thrombosis
- Chair: Julia Brown
- Conflicts: Michelle Collinson, Joyce Yeung, David Keene, Khalida Ismail, Nick Francis, Andrew Farmer
- Decision: Programme Oversight Committee to consider fund with changes
23/5 Management of bone metastasis and skeletal related events (SREs) in patients with advanced cancer
NIHR159676 - The PORTRAIT trial – Post-operative radiotherapy in surgically treated bone metastases
- Chair: Mark Peters
- Conflicts: Julia Brown, Catherine Hewitt
- Decision: Programme Oversight Committee to consider fund with changes
NIHR159393 - Short-term bracing for spinal disease in newly diagnosed myeloma: A phase III randomised controlled trial Short title: BrACing in myeloma BONE disease (BACBONE)
- Chair: Mark Peters
- Conflicts: Hema Mistry, Victoria Goodwin, Simon Gates, Michelle Collinson, Julia Brown, Joyce Yeung, Andrew Farmer
- Decision: Decline
22/170 Testosterone for the treatment of menopause symptoms beyond altered sexual function
- Chair: Julia Brown
- Conflicts: Athanasios Saratzis, Mohamed Abdel-Fattah, Nick Francis, Michelle Collinson, Mark Peters
- Left the meeting: Helen Payne
NIHR159679 - The TRIM (Testosterone Replacement in Menopause) trial: A randomised controlled trial to evaluate the clinical-effectiveness, cost-effectiveness and safety of testosterone gel for women with menopause symptoms beyond altered sexual function
- Decision: Decline
NIHR159538 - ESTEEM - Evaluating the clinical and cost-effectivenesS of TEstosteronE to improve Menopause-related quality of life
- Decision: Programme Oversight Committee to consider fund with changes
22/98 Low-dose computed tomography for the diagnosis of lung cancer in symptomatic patients seen in primary care
- Chair: Mark Peters
- Conflicts: Marta Soares, Hema Mistry, Joanna Thompson-Coon, Michelle Collinson, Julia Brown, David Keene, Joyce Yeung, Nick Francis, Andrew Farmer
NIHR155952 - Methods of Early Detection of Lung cancEr in PrimarY Care (MEDLEY)
- Decision: Programme Oversight Committee to consider fund with changes
NIHR157368 - SHOuld CT scans replace CXRs for Primary Care ChEst Imaging. The HOPE trial
- Decision: Decline
23/1 HTA Researcher-led call Primary Research
NIHR159009 - LACunar Intervention (LACI) Trial-3: Assessment of efficacy and safety of cilostazol and isosorbide mononitrate to prevent adverse outcomes in patients with cerebral small vessel disease (lacunar) ischaemic stroke
- Chair: Mark Peters
- Conflicts: Hema Mistry, Julia Brown
- Left the meeting: Matthew Moore
- Decision: Stage 2 Resubmission
22/96 Urine sampling in children
NIHR156005 - Determining the feasibility of randomising children and young people to invasive and non-invasive urine sampling techniques.
- Chair: Julia Brown
- Conflicts: David Harrison, Ashley Agus, Mark Peters, Richard Riley, Athanasios Saratzis
- Arrived at the meeting: Matthew Moore
- Decision: Shortlist
23/70 Management of bone metastasis and skeletal related events (SREs) in patients with advanced cancer
NIHR160533 - A randomised phase III trial evaluating the efficacy and cost-effectiveness of stereotactic radiotherapy compared with conventional radiotherapy for reducing pain associated with spinal metastases (SENSE)
- Chair: Mark Peters
- Conflicts: Julia Brown
- Left the meeting: Jugdeep Dhesi
- Decision: Decline
NIHR161918 - Improving outcomes in advanced cancer patients with Oligo-MEtastatic bone disease from solid tumours usinG a combination of stereotactic Ablative body radiotherapy and bone targeted systemic therapy (IOMEGA): a randomised controlled clinical trial.
- Chair: Mark Peters
- Conflicts: Marta Soares, Michelle Collinson, Dawn-Marie Walker, Anthony Kendrick, Julia Brown
- Decision: Decline
Day 2: 8 November 2023
Venue
Virtual via Microsoft Teams
Present members
Julia Brown (Chair)
Mark Peters (Deputy Chair)
Andrew Farmer (Programme Director)
Thomas Hellyer (Committee Member Development Scheme Participant)
Marta Soares
Stephanie MacNeill
Simon Gates
Ben Carter
Athanasios Saratzis
Hema Mistry
Mohamed Abdel-Fattah
David Harrison
Ashley Agus
David Keene
Garry Barton
David Green (Public Committee Member)
Khalida Ismail
Nick Francis
Victoria Goodwin
Joanna Thompson-Coon
Matthew Moore (Public Committee Member)
Dawn-Marie Walker
Sarah Markham (Public Committee Member)
Jugdeep Dhesi
Caroline Free
Michelle Collinson
Anthony Kendrick
Richard Riley
Hashim Ahmed
Secretariat
James Morris (Consultant Advisor)
Maria Hassard (Assistant Director)
Helen Payne (Senior Research Manager)
Fay Habens (Senior Research Manager)
Daniel Housego (Research Manager)
Louisa Saunders (Assistant Research Manager)
Apologies
Abdullah Pandor
Jo Dumville
Stuart McIntosh
Joyce Yeung
Observers
Catherine Hewitt
Rachel Stockley – Incoming Committee Member Development Scheme Participant
Harm Van Marwijk
Lauren Wileman (PHR Senior Research Manager)
Lien Bui (new HTA Commissioning Admin)
Quoracy information
- Voting members: 32
- Quorum = 21 = 66%
- Emergency Quorum = 16 = 50%
- Voting members present on Day 2: 28
23/41 Management of chronic plaque psoriasis
NIHR159781 - Patient-Led ‘As Needed’ treatment for chronic plaque psoriasis: a UK multi-centre randomised controlled trial (PLAN-psoriasis)
- Chair: Julia Brown
- Conflicts: Marta Soares
- Left the meeting: Matthew Moore, Mohamed Abdel-Fattah
- Decision: Decline Return to POC
NIHR160805 - An observer blind randomised controlled trial to investigate the clinical and health economic impact of prescribing adalimumab adalimuMAB instead of METHotrexate in patients with moderate psoriasis with psoriasis area and severity index (PASI) scores of 5-10 .(METHorMAB).
- Chair: Mark Peters
- Conflicts: Thomas Hellyer, Simon Gates, Ashley Agus, Athanasios Saratzis, Julia Brown
- Left the meeting: David Harrison
- Arrived at the meeting: Matthew Moore
- Decision: Decline Return to POC
23/64 HTA Researcher-led call Evidence Synthesis
NIHR160261 - Professional-supported and self-help digital psychological interventions for people with depression or anxiety: An effectiveness, cost-effectiveness, and health inequalities review
- Chair: Mark Peters
- Conflicts: None
- Arrived the meeting: Mohamed Abdel-Fattah
- Decision: Decline
NIHR160844 - An EvideNce synthesis of Acceptance & Commitment Therapy for improving distress in long-term health conditions (ENACT): Exploring efficacy, cost-effectiveness, with evidence & gap mapping to inform clinical practice
- Chair: Mark Peters
- Conflicts: Athanasios Saratzis, Michelle Collinson, Ashley Agus
- Left the meeting: Richard Riley
- Decision: Shortlist
NIHR161575 - Non-surgical interventions for pelvic organ prolapse in women: a component network meta-analysis and cost-effectiveness analysis
- Chair: Julia Brown
- Conflicts: Hashim Ahmed, Caroline Free
- Arrived at the meeting: Khalida Ismail
- Decision: Shortlist
NIHR161530 - Airway clearance techniques in critically ill patients: an evidence synthesis to inform clinical practice and future research
- Chair: Julia Brown
- Conflicts: Thomas Hellyer, Simon Gates, David Harrison, Ashley Agus, Mohamed Abdel-Fattah,
- Decision: Decline
23/43 Management of severe acute asthma in children
- Chair: Julia Brown
- Conflicts: Mohamed Abdel-Fattah, Caroline Free, David Harrison, Nick Francis, Mark Peters, Dawn-Marie Walker, Hashim Ahmed, Anthony Kendrick, Athanasios Saratzis, Thomas Hellyer, Andrew Farmer
NIHR162027 - A randomised trial of aminophylline, magnesium or salbutamol intravenous therapy for acute severe asthma in children and young people.
- Decision: Shortlist
NIHR162373 - Acute Severe asthma TReatment in Children And young People (ASTRA - CyP)
- Decision: Decline
23/63 HTA Researcher-led call Primary Research
NIHR161398 - OVATION: A randomised comparison of oral and intravenous arsenic trIoxide consolidation therapy in acute promyelocytic leukaemia
- Chair: Mark Peters
- Conflicts: Athanasios Saratzis, Hema Mistry, Mohamed Abdel-Fattah
- Left the meeting: Matthew Moore
- Decision: Decline
NIHR161851 - COmpression Stockings To Alleviate post-thrombotic syndrome (COSTA)
- Chair: Julia Brown
- Conflicts: Athanasios Saratzis, Mohamed Abdel-Fattah, Caroline Free, Jugdeep Dhesi, Hashim Ahmed
- Arrived at the meeting: Matthew Moore
- Decision: Decline
NIHR160616 - Clinical and cost-effectiveness of OptiBreech collaborative care versus standard care for women with a breech-presenting baby = 35 weeks: a stepped wedge cluster randomised controlled trial
- Chair: Julia Brown
- Conflicts: Hema Mistry, David Keene, Andrew Farmer
- Decision: Decline
23/44 Effectiveness of oral nutritional supplements in older adults with malnutrition
- Chair: Caroline Free
- Conflicts: Victoria Goodwin, Joanna Thompson-Coon, Dawn-Marie Walker, David Keene, Anthony Kendrick, Thomas Hellyer, Marta Soares, Athanasios Saratzis, Hema Mistry, David Harrison, Jugdeep Dhesi, Michelle Collinson, Mark Peters, Andrew Farmer, Julia Brown, Catherine Hewitt
- Left the meeting: Tony Kendrick, Jugdeep Dhesi, Lauren Wileman (observer), Lien Bui (observer)
NIHR160348 - REFRESH study: nutRition intervEntions For malnouRished oldEr adultS in care Homes - A parallel, superiority, assessor blinded, three-arm cluster randomised controlled trial.
- Decision: Shortlist
NIHR160451 - Building Independence with Creatine and Energy supplements in older Patients undergoing SURGery (BICEP-SURG)
- Decision: Shortlist
NIHR160960 - Maximising Mobility and Strength Training (MMoST) Randomised Controlled Trial
- Decision: Decline
NIHR162199 - The Aeonian-Trial: Addition of Essential amino acids and cholecalciferol as Oral Nutritional supplements In Adults >65 years who are malnourished or at risk of malnutrition, and Newly discharged from hospital: a randomised controlled trial
- Decision: Decline
23/42 Endoscopic modalities for detection of Barrett’s oesophagus related neoplasia
NIHR161426 - Research Title Randomised cross-over trial on biopsies targeted by Narrow-Band Imaging and Acetic acid alone or in combination versus Seattle protocol biopsies for the detection of Barrett’s oesophagus related neoplasia
- Chair: Julia Brown
- Conflicts: None
- Left the meeting: Jo Thomson-Coon, Harm Van Marwijk (observer)
- Decision: Decline