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HTA Funding Committee Public Minutes 8 - 9 March 2022

Published

25 April 2022

Version

1

Contents

Meeting

HTA Funding Committee (Clinical Evaluation and Trials)
Minutes of the March 2022 Meeting

Day 1 – Tuesday 8th March 2022

Venue

Danubius Hotel, Regents Park

Present Members

  • Professor Olivia Wu (Chair)
  • Professor Rakesh Heer (Deputy Chair)
  • Professor Andrew Farmer (HTA Programme Director)
  • Dr Jennifer Bostock (Public Committee member)
  • Dr Kate Brown
  • Dr Elizabeth Camacho
  • Professor Charlotte Coles
  • Professor Alun Davies
  • Mrs Hannah de Merode (Public Committee member)
  • Professor Jon Dorling
  • Dr Francesca Fiorentino
  • Associate Professor Paul French
  • Dr Katie Gillies
  • Professor Daniel Hind
  • Professor Sally Hopewell
  • Dr Pamela Jacobsen (Trainee Committee member)
  • Associate Professor Rebecca Kearney
  • Professor Gavin Perkins
  • Professor Thomas Pinkney
  • Professor Jonathan Rees
  • Dr Nigel Rees
  • Dr Gurdeep Sagoo
  • Professor Kapil Sayal
  • Dr Elizabeth Warburton
  • Professor James Wason
  • Professor David Weller

HTA Secretariat

  • Dr Nick Hicks (Consultant Advisor)
  • Mrs Karen Williams (Senior Research Manager)
  • Dr Brogan Ashley (Research Manager)
  • Miss Hebe Sims (Assistant Research Manager)

Apologies

  • Dr Elena Pizzo
  • Ms Joanne Haviland

Quoracy Information

Voting members: 27 (Emergency Quoracy = 14 = 50%)
Voting members present on Day 1: (100%)

Stage 2 Proposals  

21/511 HTA Researcher-led call Primary Research

Chair: Olivia Wu
Conflicts: Daniel Hind, Thomas Pinkney, Nigel Rees, Gavin Perkins, Jennifer Bostock

NIHR150364 - Prehospital Recognition and Antibiotics for emergency patients with Sepsis: evaluation of safety, costs and effectiveness (PhRASe 2) (Jenna Jones) 

Decision: Resubmission at Stage 1

21/511 HTA Researcher-led call Primary Research

Chair: Olivia Wu
Conflicts: None

NIHR150600 - The United Kingdom Arm of the Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery (TRICS IV) Trial: An international, multi-centre, randomized trial to assess the clinical and cost-effectiveness of liberal transfusion thresholds in younger patients undergoing cardiac surgery. (Gavin Murphy)

Decision: Programme Oversight Committee to consider fund with changes

21/511 HTA Researcher-led call Primary Research

Chair: Andrew Farmer
Conflicts: Katie Gillies, Elizabeth Camacho, Thomas Pinkney, Rakesh Heer, Jon Dorling, Olivia Wu, David Weller

NIHR150664 - DOes early gdM diagnosis Improve pregNancy Outcomes (DOMINO)? (Rebecca Reynolds)

Decision: Decline

21/511 HTA Researcher-led call Primary Research

Chair: Rakesh Heer
Conflicts: Rebecca Kearney, Jonathan Rees, Bethan Woods, Sally Hopewell, Jennifer Bostock

NIHR150195 - Surgery compared with sling immobilisation in the management of adults with a displaced unstable fracture of the distal clavicle: a multi-centre, non-inferiority, randomised controlled trial (DIDACT – DIsplaced DistAl Clavicle Trial) (Harvinder Pal Singh)

Decision: Programme Oversight Committee to consider fund with changes

21/504 Amiodarone vs beta blockade for new onset atrial fibrillation in adult intensive care

Chair: Olivia Wu
Conflicts: Katherine Brown, Rebecca Kearney, Thomas Pinkney, Nigel Rees, Andrew Farmer, Gavin Perkins

NIHR150027 - A randomised controlled trial to investigate clinical and cost effectiveness of Amiodarone vs Beta Blockade for new onset atrial fibRillation in icU - a Pragmatic sTudy (ABBRUPT) (Tony Whitehouse)

Decision: Programme Oversight Committee to consider fund with changes

21/504 Amiodarone vs beta blockade for new onset atrial fibrillation in adult intensive care

Chair: Olivia Wu
Conflicts: Katherine Brown, Thomas Pinkney, Rebecca Kearney, Nigel Rees, Andrew Farmer, Gavin Perkins

NIHR150481 - Atrial fibrillation management with Beta Blockade versus Amiodarone (ABBA): a randomised controlled trial (Peter Watkinson)

Decision: Decline

Stage 1 Proposals 

21/556 NIHR NICE Rolling Call (HTA Programme: Sep 21 - Jan 22)

Chair: Olivia Wu
Conflicts: Thomas Pinkney

NIHR150396 - The 7Cs Study: recognition and Care of Chronic kidney disease after Cancer or Critical Care using Cystatin C (John Prowle)

Decision: Decline

21/556 NIHR NICE Rolling Call (HTA Programme: Sep 21 - Jan 22)

Chair: Olivia Wu
Conflicts: Rakesh Heer, Thomas Pinkney, Katie Gillies, Gurdeep Sagoo

NIHR151246 - Randomised Evaluation of Stent Insertion after uncomplicated endourological Stone Treatment (RESIST) (Veeru Kasivisvanathan)

Decision: Resubmission at Stage 1

21/556 NIHR NICE Rolling Call (HTA Programme: Sep 21 - Jan 22)

Chair: Rakesh Heer
Conflicts: Andrew Farmer, Jonathan Rees, Thomas Pinkney, Rebecca Kearney, Gavin Perkins, Sally Hopewell

NIHR150983 - INITIATE: INCREASED MOBILITY IN HOSPITAL AFTER HIP FRACTURE (Rebecca Kearney)

Decision: Shortlist

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Olivia Wu
Conflicts: James Wason, Pamela Jackson

NIHR151099 - ACORN: A multi-site randomised COntrolled trial to evaluate the impact of a group tReatment for aNtenatal anxiety (Heather O'Mahen)

Decision: Resubmission at Stage 1

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Rakesh Heer
Conflicts: Olivia Wu
Left the meeting: Alun Davies, Kate Brown

NIHR151794 - DIrect oral anticoagulant Safety and efficacy: a randomised trial of the Optimal management of Left VEntricular thrombus (DISOLVE) (Divaka Perera)

Decision: Decline

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Olivia Wu
Conflicts: Thomas Pinkney, Rebecca Kearney, Gavin Perkins, Gurdeep Sagoo

NIHR151203 - Functional Assessment for Surgery by Timed Walk (FAST-Walk) study. (Tom Abbott)

Decision: Decline

Day 2 - Wednesday 9th March 2022 

Venue

Danubius Hotel, Regents Park

Present Members

  • Professor Olivia Wu (Chair)
  • Professor Rakesh Heer (Deputy Chair)
  • Professor Andrew Farmer (HTA Programme Director)
  • Dr Jennifer Bostock (Public Committee member)
  • Dr Kate Brown
  • Dr Elizabeth Camacho
  • Professor Charlotte Coles
  • Professor Alun Davies
  • Mrs Hannah de Merode (Public Committee member)
  • Professor Jon Dorling
  • Dr Francesca Fiorentino
  • Associate Professor Paul French
  • Dr Katie Gillies
  • Professor Daniel Hind
  • Professor Sally Hopewell
  • Dr Pamela Jacobsen (Trainee Committee member)
  • Associate Professor Rebecca Kearney
  • Professor Gavin Perkins
  • Professor Thomas Pinkney
  • Professor Jonathan Rees
  • Dr Nigel Rees
  • Dr Gurdeep Sagoo
  • Professor Kapil Sayal
  • Dr Elizabeth Warburton
  • Professor James Wason
  • Professor David Weller

Secretariat

  • Dr Nick Hicks (Consultant Advisor)
  • Mrs Karen Williams (Senior Research Manager)
  • Dr Brogan Ashley (Research Manager)
  • Miss Hebe Sims (Assistant Research Manager)

Apologies

  • Dr Elena Pizzo
  • Ms Joanne Haviland

Quoracy Information

Voting members: 27 (Emergency Quoracy = 14 = 50%)
Voting members present on Day 2: (100%)

Stage 1 Proposals 

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Olivia Wu
Conflicts: Rakesh Heer, Gurdeep Sagoo, James Wason

NIHR151883 - Optimum therapy for thromboembolic complications after mitral valve repair-The PROTECT MVR Trial (Enoch Akowuah)

Decision: Shortlist

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Rakesh Heer
Conflicts: Rebecca Kearney, Elizabeth Camacho, Katie Gillies, Andrew Farmer, Gavin Perkins

NIHR151372 - HEAL-D (Healthy Eating & Active Lifestyles for Diabetes): a multicentre, randomised controlled trial comparing effectiveness and cost-effectiveness of culturally-tailored versus standard diabetes self-management support programmes in Black-African and Black-Caribbean adults with type 2 diabetes (Louise Goff)

Decision: Shortlist

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Rakesh Heer
Conflicts: Andrew Farmer, Thomas Pinkney, Gavin Perkins, Elizabeth Warburton, Jennifer Bostock, David Weller

NIHR151530 - Early versus Later AntiPlatelet uSE after Chronic Subdural Haematoma (ELAPSE-CSDH) (Paul Brennan)

Decision: Decline

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Andrew Farmer
Conflicts: Olivia Wu, Rakesh Heer, Katherine Brown, Thomas Pinkney, Gavin Perkins, Katie Gillies, Alun Davies

NIHR151601 - Glucocorticoids in Adults With Acute Respiratory Distress Syndrome: Randomised Clinical Trial (GuARDS Trial) (Manu Shankar-Hari)

Decision: Shortlist

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Andrew Farmer
Conflicts: Olivia Wu, Rakesh Heer, Alun Davies, Thomas Pinkney, Elizabeth Warburton, Katie Gillies, Francesca Fiorentino

NIHR151846 - COMeT – Carotid endarterectomy vs Optimal Medical Therapy (Matthew Bown)

Decision: Shortlist

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Rakesh Heer
Conflicts: Katherine Brown, Thomas Pinkney, Gavin Perkins, Elizabeth Warburton

NIHR151716 - Randomised Trial of Early Cranioplasty (RETELL) (Adel Helmy)

Decision: Decline

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Olivia Wu
Conflicts: Thomas Pinkney, Gurdeep Sagoo, James Wason, Jennifer Bostock

NIHR151863 - The Healing of ExcisionAl wounds on Lower legs by Secondary intention (HEALS) 2 (David Veitch)

Decision: Shortlist

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Olivia Wu
Conflicts: Rebecca Kearney, Gavin Perkins, Elizabeth Camacho, Francesca Fiorentino, Nigel Rees

NIHR151533 - Neurally adjusted ventilatory assist in the adult critical care unit: A randomized, parallel group, allocation concealed, controlled, open, phase 3 pragmatic clinical and cost effectiveness trial with internal pilot (Daniel Hadfield)

Decision: Decline

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Rakesh Heer
Conflicts: Andrew Farmer, Charlotte Coles, Katie Gillies

NIHR151760 - Adjuvant radiotherapy in patients with high-risk primary cutaneous Squamous Cell Carcinoma AFTER surgery (SCC-AFTER): an open label, multicentre, two-arm phase III randomised trial (Agata Rembielak)

Decision: Shortlist

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Olivia Wu
Conflicts: Andrew Farmer
Left the meeting: Gurdeep Sagoo

NIHR151415 - Is Motivational Enhancement Therapy clinically effective and cost effective in improving adherence to continuous positive airway pressure in people with Obstructive Sleep Apnoea Hypopnoea Syndrome? (Julia Kelly)

Decision: Shortlist

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Rakesh Heer
Conflicts: Katie Gillies

NIHR151753 - EValuatIng DiurEtics in Normal CarE (EVIDENCE): - a cluster randomised study of prescribing policy for thiazide-like drugs used for primary hypertension (Alexander Doney)

Decision: Decline

21/554 Health Technology Assessment Programme Researcher-led (primary research)

Chair: Olivia Wu
Conflicts: Thomas Pinkney, Katie Gillies
Arrived at meeting: Gurdeep Sagoo

NIHR151933 - SARveillance: an international, randomised controlled trial with additional patient-preference arms of high versus lower intensity radiological surveillance following resection of primary retroperitoneal, abdominal and pelvic soft tissue sarcoma (Samuel Ford) 

Decision: Decline