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HTA Funding Committee Public Minutes 9-10 November 2021

Contents

Meeting

HTA Funding Committee (General)

Day 1 - Tuesday 9th November 2021

Venue

Virtual Meeting via Microsoft Teams

Present members

Professor Julia Brown (Chair)

Professor Rupert Pearse (Deputy Chair)

Professor Andrew Farmer (Programme Director)

Dr Ashley Agus

Professor Hashim Ahmed

Professor Julie Brittenden

Professor Matthew Costa

Dr Fay Crawford

Dr Janet Deane

Professor Jo Dumville

Professor Nick Francis

Professor Caroline Free

Professor Simon Gates

Professor Kerenza Hood

Dr David Keene

Professor Asma Khalil

Dr Stephanie MacNeill

Mr Matthew Moore (Public Committee Member)

Professor Mark Peters

Professor Craig Ramsay

Mrs Amanda Roberts (Public Committee Member)

Associate Professor Athanasios Saratzis

Dr Marta Soares

Dr Martin Thomas

Associate Professor Jo Thompson-Coon

Dr Sara Twaddle

NETSCC, HTA Secretariat

Dr Simon Fraser (Consultant Advisor)

Laura Bradley (Research Manager)

Cristina Lujan Barroso (Research Manager)

Karen Williams (Senior Research Manager)

Louisa Saunders (Assistant Research Manager)

Apologies

Professor Tammi Walker 

Observers

Mr David Green (Public Committee Member)

Dr Emma Small (HCR Wales) 

Quoracy Information

Voting members: 26 Quorum = 17

Voting members present on Day 1: 25 (93%)

Stage 2 Proposals

20/109: Shorter vs longer fixed-course antibiotic treatments

Chair: Professor Julia Brown
Conflicts: Janet Deane, Simon Fraser, Stephanie MacNeill, Amanda Roberts, Andrew Farmer, Kerenza Hood, Nick Francis

NIHR134867: Cellulitis Optimal Antibiotic Treatment: COAT study
(Professor Nick Francis, University of Southampton)

Decision: Programme Oversight Committee to consider fund with changes

 

20/109: Shorter vs longer fixed-course antibiotic treatments

Chair: Professor Julia Brown
Conflicts: Athanasios Saratzis, Simon Gates

NIHR133875: SHorter vs Longer CoUrse AnTibiotics – an AdaptivE BaYEsian Design Study (SHUTEYE)
(Honorary Professor Tony Whitehouse, University Hospitals Birmingham NHS Foundation Trust)

Decision: Decline

 

20/109: Shorter vs longer fixed-course antibiotic treatments

Chair: Professor Rupert Pearse
Conflicts: David Keene, Simon Gates
Left meeting: Emma Small (observer), Marta Soares

NIHR134534: Cefalexin for UTIs – Right treatment Length in Young children (the CURLY trial). A multi-centre, randomised trial to determine the optimal duration of cefalexin therapy for the treatment of febrile urinary tract infections in children.
(Dr Stuart Hartshorn, Birmingham Women's and Children's NHS Foundation Trust)

Decision: Programme Oversight Committee to consider fund with changes

 

20/109: Shorter vs longer fixed-course antibiotic treatments

Chair: Professor Rupert Pearse
Conflicts: Andrew Farmer, Kerenza Hood, Nick Francis
Arrived meeting: Emma Small (observer), Marta Soares

NIHR134854: DURATION OF ANTIBIOTIC TREATMENT IN URINARY TRACT INFECTION (DurATIon-UTI Trial) Impact of duration of antibiotic therapy on effectiveness, safety and selection of antibiotic resistance in adult women with urinary tract infections (UTI): a randomised controlled trial.
(Associate Professor Gail Hayward, University of Oxford)

Decision: Programme Oversight Committee to consider fund with changes

 

20/109: Shorter vs longer fixed-course antibiotic treatments

Chair: Professor Rupert Pearse
Conflicts: Nick Francis

NIHR133876: Seven versus Fourteen Days Antibiotics for Patients with Bronchiectasis Requiring Intravenous Antibiotics- SBIVA Study
(Professor Adam Hill, NHS Education for Scotland)

Decision: Programme Oversight Committee to consider fund with changes

 

20/109: Shorter vs longer fixed-course antibiotic treatments

Chair: Professor Rupert Pearse
Conflicts: Ashley Agus, Hashim Ahmed, Simon Gates

NIHR134101: A randomised controlled trial of SHORT duration antibiotic thERapy for critically ill patients with sepsis: SHORTER Trial
(Dr Thomas Hellyer, University of Newcastle upon Tyne)

Decision: Programme Oversight Committee to consider fund with changes

 

21/02: HTA Researcher-led call Evidence Synthesis

NIHR134670: The benefits, harms and costs of surveillance for hepatocellular carcinoma in people with cirrhosis: synthesis of observational and diagnostic test accuracy data and cost–utility analysis
(Mr Gabriel Rogers, The University of Manchester)

Chair: Professor Julia Brown
Conflicts: Stephanie MacNeill, Joanna Thompson-Coon, Jo Dumville
Decision: Programme Oversight Committee to consider fund with changes

 

21/02: HTA Researcher-led call Evidence Synthesis

NIHR134786: The effectiveness of antibiotic therapies for pelvic inflammatory disease: a systematic review, core outcome set development and network meta-analysis
(Dr Ruaraidh Hill, University of Liverpool)

Chair: Professor Julia Brown
Conflicts: Kerenza Hood, Simon Gates
Left meeting: Matt Costa
Decision: Decline

 

21/01: HTA Researcher-led call Primary Research

NIHR134746: Perineural Local Anaesthetic Catheter aftEr Major lowEr limb amputatioN Trial (PLACEMENT)
(Mr David Bosanquet, Aneurin Bevan University Health Board)

Chair: Professor Julia Brown
Conflicts: Athanasios Saratzis, Kerenza Hood
Left meeting: Hashim Ahmed
Decision: Programme Oversight Committee to consider fund with changes

 

21/01: HTA Researcher-led call Primary Research

NIHR134660: Randomised Evaluation of Sodium Dialysate Levels on Vascular Events (RESOLVE).
(Professor David Wheeler, University College London)

Chair: Professor Julia Brown
Conflicts: Simon Fraser, Stephanie MacNeill
Decision: Programme Oversight Committee to consider fund with changes

 

21/01: HTA Researcher-led call Primary Research

NIHR133889: Palliative Long-term Abdominal Drains Versus Repeated Drainage in Untreatable Ascites Due to Advanced Cirrhosis: A Randomised Controlled Trial (REDUCe 2 Study)
(Professor Sumita Verma, University of Sussex)

Chair: Professor Julia Brown
Conflicts: Simon Fraser
Decision: Programme Oversight Committee to consider fund with changes

 

HTA Stage 1 Applications

21/547 - VTC 09/01/47, Fast-Forward: RCT testing 1-week curative whole breast radiotherapy against standard 3-week schedule in women with early breast cancer

Chair: Professor Julia Brown
Conflicts: Marta Soares

NIHR150755: FAST-Forward phase III randomised controlled trial of 1 week vs 3 weeks of curative whole breast radiotherapy in early breast cancer: 5 (nodal substudy) & 10 year outcomes (main trial)
(Adrian Brunt, The Institute of Cancer Research: Royal Cancer Hospital)

Decision: Shortlist

 

21/509

Chair: Professor Rupert Pearse
Conflicts: None

NIHR150071: The clinical and cost effectiveness of internet-delivered self-help Acceptance and Commitment Therapy for family carers of people with dementia (iACT4CARERS): A randomised controlled trial with ethnically diverse family carers
(Naoko Kishita, University of East Anglia)

Decision: Shortlist

 

Day 2 - Wednesday 10th November 2021

Venue

Virtual Meeting via Microsoft Teams

Present members

Professor Julia Brown (Chair)

Professor Rupert Pearse (Deputy Chair)

Professor Andrew Farmer (Programme Director)

Dr Ashley Agus

Professor Hashim Ahmed

Professor Julie Brittenden

Dr Fay Crawford        

Dr Janet Deane

Professor Jo Dumville

Professor Nick Francis

Professor Caroline Free

Professor Simon Gates

Professor Kerenza Hood

Dr David Keene

Professor Asma Khalil

Dr Stephanie MacNeill

Mr Matthew Moore (Public Committee Member)

Professor Mark Peters

Professor Craig Ramsay

Mrs Amanda Roberts (Public Committee Member)

Associate Professor Athanasios Saratzis

Dr Marta Soares

Dr Martin Thomas

Associate Professor Jo Thompson-Coon

Dr Sara Twaddle

 

NETSCC, HTA Secretariat

Dr Simon Fraser (Consultant Advisor).

Laura Bradley (Research manager)

Cristina Lujan Barroso (Research manager)

Karen Williams (Senior Research Manager)

Louisa Saunders (Assistant Research Manager)

 

Apologies

Professor Tammi Walker

Professor Matthew Costa

 

Observers

Mr David Green (Public Committee Member)

Dr Emma Small (HCR Wales)

Dr Julie Simpson (CSO Scotland)

 

Quoracy Information

Voting members: 26 Quorum = 17

Voting members present on Day 2: 24 (89%)

 

21/501 - Health and social care outcomes and cost-effectiveness of assistive technologies

Chair: Professor Julia Brown
Conflicts: None

NIHR150271: Evidence synthesis for assistive technologies to support adults living at home with long-term incontinence or toilet-use problems
(Catherine Murphy, University of Southampton)

Decision: Decline

 

21/502 -  Osteoarthritis in older or frail people with multiple long-term conditions

Chair: Professor Julia Brown
Conflicts: Kerenza Hood, Asma Khalil, Marta Soares, Andrew Farmer, David Keene

NIHR150184: NUTS trial - Nerve modUlation for Treatment of Shoulder arthritis
(Stephen Gwilym, University of Oxford)

Decision: Shortlist

 

21/502 -  Osteoarthritis in older or frail people with multiple long-term conditions

Chair: Professor Rupert Pearse
Conflicts: Nick Francis, Kerenza Hood, Craig Ramsay, Martin Thomas, Joanna Thompson-Coon, Andrew Farmer, David Keene, Janet Deane

NIHR150050: Clinical and cost-effectiveness of a NICE-informed, person-centred, management programme for older adults with osteoarthritis (OA) and multiple long-term conditions: a multicentre, primary care, randomised, parallel-group, superiority trial: the PERSONA trial.
(Emma Healey, Keele University)

Decision: Shortlist

 

21/502 -  Osteoarthritis in older or frail people with multiple long-term conditions

Chair: Professor Rupert Pearse
Conflicts: Nick Francis, Kerenza Hood, Craig Ramsay, Martin Thomas, Joanna Thompson-Coon, Andrew Farmer, David Keene, Janet Deane
Left meeting: Stephanie MacNeill

NIHR150083: MulTI-domain Self-management in Older People wiTh OstEoarthritis and Multi-Morbidities (TIPTOE)
(Kate Button, Cardiff University)

Decision: Shortlist

 

21/502 -  Osteoarthritis in older or frail people with multiple long-term conditions

Chair: Professor Rupert Pearse
Conflicts:Nick Francis, Kerenza Hood, Craig Ramsay, Martin Thomas, Joanna Thompson-Coon, Andrew Farmer, David Keene, Janet Deane

NIHR150592: OPTIMISE: Osteoarthritis Package of care To Improve Multi-morbid older Individuals' Symptoms Effectively
(Hamish Simpson, The University of Edinburgh)

Decision: Shortlist

 

HTA Commissioned Stage 1 Proposals

21/541 - Medication support interventions and strategies for people with learning disabilities

Chair: Professor Julia Brown
Conflicts: Joanna Thompson-Coon, Jo Dumville,  Simon Fraser

NIHR150619: Medication support interventions and strategies for people with learning disabilities
(Rohit Shankar, University of Plymouth)

Decision: Decline

 

NIHR150687: Medication support interventions and strategies for people with learning disabilities - a mixed methods evidence synthesis
(Yen-Fu Chen, University of Warwick)

Decision: Shortlist

 

NIHR150759: Supporting Medication for people with Learning Disability Equitably (SMiLE)
(Alison Doherty, University of Central Lancashire)

Decision: Decline

 

NIHR150760: What are the effective and cost-effective support interventions and strategies for people with learning disabilities who use medications for long-term conditions?
(Ruth Paterson, The University Court of Edinburgh Napier University)

Decision: Decline

 

HTA Researcher-Led (PR) Stage 1

NIHR150582: Evaluating the clinical and cost-effectiveness of a multicomponent intervention for the Prevention of leg Ulcer REcurrence (PURE): A randomised controlled trial
(Alun Davies, Imperial College London)

Chair: Professor Rupert Pearse
Conflicts: Hashim Ahmed, Julie Brittenden, Jo Dumville, Craig Ramsay, Athanasios Saratzis, Janet Deane
Decision: Decline

 

HTA Researcher-Led (PR) Stage 1

NIHR150666: The Colorectal SSI (ColoSSIs) trial
(Angus Watson, NHS Highland)

Chair: Professor Julia Brown
Conflicts: Craig Ramsay
Left meeting: Stephanie MacNeill
Decision: Decline

 

HTA Researcher-Led (PR) Stage 1 NICE CALL

NIHR150579: Antihypertensive Treatment Evaluation in Multimorbid and Polymedicated Patients Trial (ATEMPT): A randomised controlled trial
(Kazem Rahimi, University of Oxford)

Chair: Professor Julia Brown
Conflicts: Andrew Farmer
Decision: Decline

 

HTA Researcher-Led (PR) Stage 1

NIHR150515: Clinical accuracy of risk prediction models for early onset neonatal infection in the UK
(Jane Daniels, The University of Nottingham)

Chair: Professor Julia Brown
Conflicts: Asma Khalil
Decision: Decline

 

HTA Researcher-Led (PR) Stage 1

NIHR150532: Antiplatelet Secondary Prevention International Randomised trial after INtracerebral haemorrhaGe (ASPIRING)
(Rustam Salman, The University of Edinburgh)

Chair: Professor Julia Brown
Conflicts: Andrew Farmer, Kerry Hood
Decision: Shortlist

 

HTA Researcher-Led (PR) Stage 1

NIHR150373: DECIPHER: Developing ctDNA guided adjuvant therapy for oesophagogastric cancer
(Elizabeth Smyth, University of Southampton)

Chair: Professor Julia Brown
Conflicts: Nick Francis, Martin Thomas, Simon Fraser
Decision: Decline