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HTA Remit and Competitiveness teleconference - Public minutes September 2021

Published

02 February 2022

Version

1.0 - September 2021

Contents

Friday 24 September 2021, 10:00am - 1:00pm

Present Members

Professor Andrew Farmer (HTA Programme Director) (Chair)
Professor Olivia Wu (Chair of CET Funding Committee) – from 11:30
Professor Julia Brown (Chair of General Funding Committee)
Professor Marian Knight (Chair of Commissioning Funding Committee)
Professor Anthony De-Soyza (Chair of Prioritisation Committee B)
Associate Professor Kamal Mahtani (Chair of Prioritisation Committee A)

NETSCC Secretariat

Dr Nick Hicks (NETSCC Consultant Advisor)
Dr Brogan Ashley (Research Manager)
Ms Nikita Belavate (Administrator)
Observers: Dr Nicola McArdle (Assistant Research Manager)
Apologies: Mrs Vicky Taylor (Assistant Director)
Mrs Karen Williams (Senior Research Manager)

21/511 HTA Researcher-led call Primary Research

NIHR150576 - A randomised controlled trial to evaluate the effectiveness and cost effectiveness of Systemic Autism-related Family Enabling (SAFE), an intervention for families of autistic children (Associate Professor Rebecca Stancer)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150630 - The impact of a complex arts-based intervention on the mental health and wellbeing of patients with end-stage kidney disease whilst receiving haemodialysis: A cluster randomised trial. (Dr Helen Noble)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Kamal Mahtani
Declared a conflict and left the call: None Declared
Recommendation: Out of Remit

21/511 HTA Researcher-led call Primary Research

NIHR150598 - Haemodynamic Optimisation in Femoral Fracture- The HOFF Trial (Dr Simon James Davies)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Kamal Mahtani
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/512 HTA Researcher-led call Evidence Synthesis

NIHR150428 - Orthoptic service provision for people with strabismus, ocular motility conditions and visual impairment (Professor Fiona J Rowe)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Kamal Mahtani
Declared a conflict and left the call: None Declared
Recommendation: Out of Remit

21/511 HTA Researcher-led call Primary Research

NIHR150312 - An Adapted Home-Based Cardiac Rehabilitation Programme for Acute Secondary Prevention following a TIA and 'Minor' Stroke: A Randomised Controlled Trial (Dr Neil Heron)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Kamal Mahtani
Declared a conflict and left the call: Olivia Wu
Recommendation: Out of Remit and Uncompetitive

21/511 HTA Researcher-led call Primary Research

NIHR150364 - Prehospital Recognition and Antibiotics for emergency patients with Sepsis: evaluation of safety, costs and effectiveness (PhRASe 2) (Dr Jenna Jones)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150634 - Patients with symptomatic gallstones at risk of bile duct stones, who are fit and require elective or urgent laparoscopic cholecystectomy (LOtUS) (Mr Somaiah Aroori)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150245 - Paclitaxel or sirolimus coated balloons for ArterioVEnous fistulas (PAVE-2 trial) (Dr Michael Robson)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Out of Remit

21/502 Osteoarthritis in older or frail people with multiple long-term conditions

NIHR150444 - Comprehensive Personalised Package of Care for Older People with Knee Osteoarthritis and other Multiple Long-term Conditions: A randomised controlled trial including internal pilot and embedded process evaluation (COMPLETE study) (Professor Philip Conaghan)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Julia Brown
Declared a conflict and left the call: None Declared
Recommendation: Out of Remit

21/502 Osteoarthritis in older or frail people with multiple long-term conditions

NIHR150083 - MulTI-domain Self-management in Older People wiTh OstEoarthritis and Multi-Morbidities (TIPTOE) (Dr Kate Button)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/510 NIHR NICE Rolling call – HTA

NIHR150666 - The Colorectal SSI (ColoSSIs) trial (Professor Angus James Mackintosh Watson)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150544 - PravastatIn tO preveNt prEtErm biRth (PIONEER) study: a parallel group randomised placebo-controlled trial with blinding (Dr Katherine Alice Birchenall)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Julia Brown
Declared a conflict and left the call: Marian Knight
Recommendation: Out of Remit

21/511 HTA Researcher-led call Primary Research

NIHR150563 - INduCtion of Labour in women with Uncomplicated pregnancies and risk factors for aDverse perinatal outcomEs (INCLUDE): A randomised trial with qualitative and economic evaluation, and individual participant data meta-analysis (Professor Shakila Thangaratinam)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: Olivia Wu, Marian Knight
Recommendation: Proceed to Funding Committee

21/510 NIHR NICE Rolling call – HTA

NIHR150581 - Glucocorticoids in Adults With Acute Respiratory Distress Syndrome: Randomised Clinical Trial (GuARDS Trial) (Professor Manu Shankar-Hari)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: Olivia Wu
Recommendation: Uncompetitive

21/502 Osteoarthritis in older or frail people with multiple long-term conditions

NIHR150592 - OPTIMISE: Osteoarthritis Package of care To Improve Multi-morbid older Individuals' Symptoms Effectively (Professor Hamish Simpson)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Julia Brown
Declared a conflict and left the call: Olivia Wu
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150662 - The PIPAC-UK Trial: A randomised-controlled phase II/III basket trial of the effectiveness of Pressurised IntraPeritoneal Aerosolised Chemotherapy (PIPAC), for the treatment of ovarian, bowel and stomach cancer with peritoneal metastases. (Professor Jared Torkington)

Chair: Marian Knight
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: Andrew Farmer
Recommendation: Out of Remit

21/511 HTA Researcher-led call Primary Research

NIHR150026 - ALGORITHM DRIVEN PROTAMINE FOR REVERSAL OF HEPARIN IN CAROTID ENDARTERECTOMY (PRoCEA) (Dr Florian Falter)

Chair: Anthony De-Soyza
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: Andrew Farmer, Marian Knight
Recommendation: Proceed to Funding Committee

21/510 NIHR NICE Rolling call – HTA

NIHR150579 - Antihypertensive Treatment Evaluation in Multimorbid and Polymedicated Patients Trial (ATEMPT): A randomised controlled trial (Professor Kazem Rahimi)

Chair: Anthony De-Soyza
Declared a conflict, remained in the teleconference: Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150122 - Comparison of haemorrhoid artery ligation (HAL) versus superior rectal artery embolisation (SRAE) for the treatment of Grade 2 or 3 haemorrhoids. Short title: The HAL-EMBO trial. (Dr Clare Louise Bent)

Chair: Olivia Wu
Declared a conflict, remained in the teleconference: Kamal Mahtani, Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150336 - Analysis of Clinical Practice Research Datalink (CPRD) data and modelling to demonstrate the potential benefits from wider use of Bisphosphonates in the NHS (Dr Stuart Redding)

Chair: Olivia Wu
Declared a conflict, remained in the teleconference: Kamal Mahtani, Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Out of Remit

21/511 HTA Researcher-led call Primary Research

NIHR150588 - A randomised controlled trial comparing videolaryngoscopy to standard laryngoscopy for neonatal intubation. The VIBE study (VIdeo for Baby Endotracheal intubation) (Dr Joyce O'Shea)

Chair: Olivia Wu
Declared a conflict, remained in the teleconference: Kamal Mahtani
Declared a conflict and left the call: Andrew Farmer, Marian Knight
Recommendation: Proceed to Funding Committee

21/502 Osteoarthritis in older or frail people with multiple long-term conditions

NIHR150050 - Clinical and cost-effectiveness of a NICE-informed, person-centred, management programme for older adults with osteoarthritis (OA) and multiple long-term conditions: a multicentre, primary care, randomised, parallel-group, superiority trial: the PERSONA t (Dr Emma Louise Healey)

Chair: Olivia Wu
Declared a conflict, remained in the teleconference: Kamal Mahtani
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150637 - Physiological versus Right ventricular pacing Outcome Trial Evaluated for bradyCardia Treatment UPgrades: PROTECT-UP (Dr Daniel Keene)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Out of Remit

21/511 HTA Researcher-led call Primary Research

NIHR150587 - Impact of a screening and management programme for cardiovascular disease in patients with chronic obstructive pulmonary disease (COPD) in primary care: a data-enabled cluster randomised trial and economic evaluation (Professor Jennifer Kathleen Quint)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: Anthony De-Soyza
Recommendation: Out of Remit

21/511 HTA Researcher-led call Primary Research

NIHR150616 - Reducing Healthcare Inequalities for People with Diabetes Through Standardised Pre-Clinic Assessment (Professor Katharine Barnard-Kelly)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Out of Remit

21/511 HTA Researcher-led call Primary Research

NIHR150589 - A randomised control trial of the combination of vaginal progesterone and oral aminophylline to prevent spontaneous preterm birth and improve perinatal outcomes: the ProgrAm study. (Dr Angela Yulia)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: Marian Knight
Recommendation: Out of Remit

21/511 HTA Researcher-led call Primary Research

NIHR150621 - State-of-the-art technology in care home setting: effectiveness and impact on residents, relatives and staff health and care outcomes (the SIRENE Study) (Dr Laura Hughes)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Out of Remit

21/509 Dementia Call

NIHR150257 - Interventional, prospective, randomized, double-blind, placebo-controlled and parallel assignment study, in which 200 patients with MCI receive 3 types of intervention tES: 1 received 35 sessions on the fronto-orbital cortex, 2 received 35 sessions on tem (Dr Moises Aguilar Domingo)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Out of Remit

21/501: Health and social care outcomes and cost-effectiveness of assistive technologies

NIHR150271 - Evidence synthesis for assistive technologies to support adults living at home with long-term incontinence or toilet-use problems (Dr Catherine Murphy)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150582 - Evaluating the clinical and cost-effectiveness of a multicomponent intervention for the Prevention of leg Ulcer REcurrence (PURE): A randomised controlled trial (Professor Alun H Davies)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: Olivia Wu
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150142 - Clarifying the patient benefit of different rhythm control strategies for patients with atrial fibrillation in the United Kingdom (Dr Rui Providencia)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150600 - The United Kingdom arm of the Transfusion Requirements in Cardiac Surgery IV (TRICS IV) trial (Professor Gavin James Murphy)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150343 - Optimum therapy for thromboembolic complications after mitral valve repair-The PROTECT MVR Trial (Mr Enoch Francis Akowuah)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Anthony De-Soyza
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150660 - A multicentre randomised controlled trial comparing a locking plastic clip to other methods of cystic duct closure in laparoscopic cholecystectomy (removal of the gallbladder by keyhole surgery) to reduce the risk of postoperative bile leak.The LapLock St (Mr Bhaskar Kumar)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150195 - Surgery compared with sling immobilisation in the management of adults with a displaced unstable fracture of the distal clavicle: a multi-centre, non-inferiority, randomised controlled trial (DIDACT – DIsplaced DistAl Clavicle Trial) (Associate Professor Harvinder Pal Singh)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150510 - Supporting women With postnatal weight mAnagemeNt: A multi-centre randomised controlled trial of clinical and cost-effectiveness of a commercial weight management programme for postnatal weight management support. SWAN II study. (Professor Debra Bick OBE)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150628 - An Open-Label, Multicentre, Randomised Controlled Phase III Trial Assessing the Benefits of Upfront Surgery versus Active Surveillance in Stage IV Grade I/II Small Intestinal Neuroendocrine Tumours (Mr Samuel John Ford)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/511 HTA Researcher-led call Primary Research

NIHR150610 - Tube versus Trabeculectomy in Uveitic Glaucoma (TTUG) study (Mr Velota Ching Tak Sung)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: Olivia Wu
Recommendation: Proceed to Funding Committee

21/510 NIHR NICE Rolling call – HTA

NIHR150515 - Clinical accuracy of risk prediction models for early onset neonatal infection in the UK (Professor Jane Daniels)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: Olivia Wu, Marian Knight
Recommendation: Proceed to Funding Committee

21/502 Osteoarthritis in older or frail people with multiple long-term conditions

NIHR150184 - NUTS trial Nerve modUlation for Treatment of Shoulder arthritis (Associate Professor Stephen Gwilym)

Chair: Olivia Wu
Declared a conflict, remained in the teleconference: Kamal Mahtani, Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

21/510 NIHR NICE Rolling call – HTA

NIHR150532 - Antiplatelet Secondary Prevention International Randomised trial after INtracerebral haemorrhaGe (ASPIRING) (Professor Rustam Al-Shahi Salman)

Chair: Olivia Wu
Declared a conflict, remained in the teleconference: Kamal Mahtani, Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

21/509 Dementia Call

NIHR150071 - The clinical and cost effectiveness of internet-delivered self-help Acceptance and Commitment Therapy for family carers of people with dementia (iACT4CARERS): A randomised controlled trial with ethnically diverse family carers (Associate Professor Naoko Kishita)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

21/510 NIHR NICE Rolling call – HTA

NIHR150373 - DECIPHER: Developing ctDNA guided adjuvant therapy for oesophagogastric cancer (Dr Elizabeth Catherine Smyth)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None Declared
Declared a conflict and left the call: None Declared
Recommendation: Proceed to Funding Committee

 Summary