Minutes for the Research for Patient Benefit (RfPB) programme East Midlands Regional Advisory Committee meeting to discuss Stage 2 applications to competition 44 and Stage 1 applications to competition 45.
Date and Location
Tuesday 14 September 2021 Virtual Meeting
In attendance
Committee members
Professor Roshan das Nair
Mrs Ajanta Biswas
Professor Matthew Bown
Dr Apostolos Fakis
Dr Clare Gillies
Dr Louise Jackson
Professor Dileep Lobo
Dr Nicola Mackintosh
Dr Joseph Manning
Dr Jatinder Minhas
Professor Richard Morriss
Ms Pamela Rees
Miss Amanda Rudczenko
Professor Catherine Sackley
Dr Don Sharkey
Secretariat
Dr Ianina Conte (NIHR CCF)
Dr Phoebe Walsh (NIHR CCF)
Ms Katie Prangle (NIHR CCF)
Ms Ludy Hills (NIHR CCF)
Professor Sue Ziebland (Programme Director)
Observers
Mr Martin Eden - (RDS NW)
Dr Jennifer Lynch - (RDS EE)
Dr Chloe Alexander (SSCR - University of Birmingham)
Apologies
Apologies were received from Dr Paul Leighton, Professor A. Niroshan Siriwardena, Professor Graham Law
Competition 44 stage 2 applications considered
1.1 NIHR203165: A Multicentre Open-label, Feasibility Study of the Use of a Short-term Low Energy Diet in Obese Adolescents with Type 2 Diabetes Mellitus
Conflicts: Dr Joseph Manning, Professor Roshan das Nair, Dr Don Sharkey and
Professor Catherine Sackley left the room.
Final outcome: Rejected
1.2 NIHR203121: Covid-19 vaccination in inflammatory conditions treated with immune suppressing drugs: a study of clinical effectiveness and vaccine safety using data from the Clinical Practice Research Datalink (CPRD).
Conflicts: Dr Joseph Manning, Professor Roshan das Nair, Dr Don Sharkey remained out of the room.
Final outcome: Conditional support
1.3 NIHR203058: Preventing Acute Kidney Injury (AKI) in patients with Peripheral Arterial Disease (PAD) and Chronic Kidney Disease (CKD): the PAD Endovascular AKi (PEAK) care checklist.
Conflicts: Professor Matthew Bown and Dr Jatinder Minhas left the room.
Final outcome: Rejected
1.4 NIHR203104: Support for induction of labour: an evidence-based, inclusive and co-produced digital resource (SOLID)
Conflicts: Dr Nicola Mackintosh, Dr Joseph Manning, Professor Roshan das Nair,
Dr Don Sharkey and Professor Catherine Sackley left the room.
Final outcome: Rejected
1.5 NIHR203050: Core Outcome Set Taskforce for Cystic Fibrosis (COST-CF): a patient-initiated core outcome set for CF.
Conflicts: Professor Roshan das Nair, Dr Joseph Manning and Dr Don Sharkey remained out of the room.
Final outcome: Rejected
ACTION: NIHR CCF to write to applicants explaining reasons for rejection.
1.6 NIHR203191: Digital Assessment of Wellbeing in New Parents (DAWN-P): a feasibility study of digital screening for postnatal depression
Conflicts: Mr Martin Eden ( RDS observer) left the room
Final outcome: Conditional support
1.7 NIHR203080: MAnnitol for Cerebral oEdema after IntraCerebral Haemorrhage (MACE-ICH): a feasibility trial
Conflicts: Dr Jatinder Minhas, Professor Roshan das Nair and Dr Don Sharkey
left the room.
Final outcome: Conditional support
Competition 45 stage 1 applications considered
2.1 NIHR203521: Understanding the lived experience and impact of itch in end-stage kidney disease to develop and implement a stepwise, patient-centred pathway.
Conflicts: Dr Jatinder Minhas remained out of the room. Dr Clare Gillies, Dr Nicola Mackintosh, Professor Matthew Bown and Ms Pamela Rees left the room.
Outcome: Rejected
ACTION: NIHR CCF to write to applicants explaining reasons for rejection.
2.2 NIHR203627: Developing a core outcome set for medicines safety at transitions of care: a systematic review, qualitative study, and Delphi consensus.
Conflicts: Professor Catherine Sackley left the room
Outcome: Rejected
2.3 NIHR203661: Enhancing consultations in oncology: Feasibility randomised controlled trial of a structured consultation framework designed with doctors and patients.
Conflicts: Professor Roshan das Nair, Professor Matthew Bown and Professor Richard Morriss left the room.
Outcome: Invite to Stage 2
2.4 NIHR203619: A randomised feasibility study with a parallel process evaluation of digital prehabilitation in patients undergoing treatment for oesophago-gastric cancer.
Conflicts: Dr Louise Jackson left the room
Outcome: Invite to Stage 2
2.5 NIHR203621: Development and validation of a prediction model for rheumatoid arthritis using primary care health records
Conflicts: Dr Louise Jackson remained out of the room. Professor Roshan das Nair left the room.
Outcome: Invite to Stage 2
2.6 NIHR203527: WONDER: HIV in Women bOne miNeral Density fracturE and fRailty - an exploratory study of current knowledge of and desires for further information about low bone mineral density, fracture risk and frailty in women living with HIV
Conflicts: Dr Louise Jackson remained out of the room and Dr Nicola Mackintosh left the room.
Outcome: Invite to Stage 2
2.7 NIHR203631: Development and refinement of a fit-for-purpose physical exercise intervention for young people in treatment for anxiety
Conflicts: Professor Roshan das Nair and Dr Apostolos Fakis left the room. Professor Matthew Bown assumed the Chair.
Outcome: Rejected
2.8 NIHR203515: Relational Approach to Treating Self-Harm (RelATe): A Feasibility Study of Cognitive Analytic Therapy for People who Self-Harm
Conflicts: Professor Richard Morriss and Mr Martin Eden left the room.
Outcome: Invite to Stage 2
2.9 NIHR203581: Outcomes and Experiences of Transgender and Gender Non-Conforming People with Autism Accessing a National Gender Service
Conflicts: Professor Richard Morriss remained out of the room
Outcome: Reject
Outcomes tables
The tables below display the mean score for each application that was assessed in the regional assessment committee meeting, and excludes applications which were rejected during the scrutiny and triage processes. The number of applications receiving each mean score are listed. The RfPB fundable range is 6-10, although a score of 6-10 does not guarantee funding or an invitation to Stage 2. In exceptional circumstances and with approval from the Programme Director, applications may be invited/funded which fall below the fundable range.
In exceptional circumstances, applications which fall below the fundable range may be invited to Stage 2 or recommended for funding by the Committee. The Programme Director reviews in detail any applications recommended for funding with a score below 7.
Competition 45 stage 1
| Score | Range | Number of applications |
|---|---|---|
| 9.0 - 10.0 | Invited | 0 |
| 8.0 - 8.9 | Invited | 0 |
| 7.0 - 7.9 | Invited | 2 |
| 6.0 - 6.9 | Invited | 3 |
| 5.0 - 5.9 | Rejected | 3 |
| 4.0 - 4.9 | Rejected | 1 |
| 3.0 - 3.9 | Rejected | 0 |
| 2.0 - 2.9 | Rejected | 0 |
| 1.0 - 1.9 | Rejected | 0 |
Competition 44 stage 2
| Score | Range | Number of applications |
|---|---|---|
| 9.0 - 10.0 | Fundable | 0 |
| 8.0 - 8.9 | Fundable | 0 |
| 7.0 - 7.9 | Fundable | 2 |
| 6.0 - 6.9 | Fundable | 1 |
| 5.0 - 5.9 | Rejected | 3 |
| 4.0 - 4.9 | Rejected | 1 |
| 3.0 - 3.9 | Rejected | 0 |
| 2.0 - 2.9 | Rejected | 0 |
| 1.0 - 1.9 | Rejected | 0 |