Published: 31 January 2024
Taking a nutritional supplement before and during pregnancy could promote healthy weight in childhood, an NIHR-supported study has found.
The research is part of the international NiPPeR study. The study is a collaboration between the NIHR Southampton Biomedical Research Centre (BRC), the University of Southampton, the Liggins Institute at the University of Auckland, the National University of Singapore and the Agency for Science, Technology and Research (A*STAR) in Singapore.
How the study worked
Rates of childhood obesity are rising in many countries, particularly in less advantaged groups. Obesity increases the risk of many health diseases. These include type 2 diabetes, heart disease and some types of cancer.
Around 500 women from the UK, New Zealand and Singapore took part in this study. They were randomly allocated to two groups.
One group received an enriched supplement - including vitamins B2, B6, B12, D, probiotics and myoinositol - alongside a standard pregnancy supplement.
The other group received a standard pregnancy supplement alone. Neither the women nor their medical teams knew which group they were in.
The researchers checked in on the children when they were two years old. There were half as many obese children in the cohort whose mothers were in the enriched group (9% versus 18%). These children were almost 25% less likely to have experienced “rapid weight gain”, which often leads to obesity.
The new analysis by researchers in the UK, New Zealand and Singapore has been published in BMC Medicine.
A ‘special opportunity’
Professor Keith Godfrey from the University of Southampton (UoS) and the NIHR Southampton BRC is the study’s Chief Investigator. He said: “Preventing obesity is one of the most important things we can do, as treating obesity is much more difficult. The new findings suggest the period before and during pregnancy may provide a ‘special opportunity’. Supporting better nutritional status for the mother at this time could have lasting benefits for her child.”
Professor Wayne Cutfield is a professor of paediatric endocrinology at the Liggins Institute in Auckland, and one of the leaders of the research. He said: “In a world of obesity, our data suggests supplementing mums before and during pregnancy can have benefits way beyond the pregnancy and for the women involved. It can impact their baby into childhood and potentially beyond.”
Professor Marian Knight, NIHR Scientific Director for Infrastructure said: "These latest findings are a step towards beginning to understand and prevent childhood obesity. Pioneering nutrition, lifestyle and metabolism research is at the heart of our NIHR Southampton Biomedical Research Centre. Working closely with global partners, the aim of this ambitious study is to continue making discoveries that will help give every child the best start in life.”
Future research
The enhanced supplement contained seven additional micronutrients.
More research is needed to identify which of the nutrients in the supplement are most beneficial. Any of them - or a combination - could have impacted the metabolism and development of the children and the likelihood of obesity.
Professor Cutfield said: “We do not yet know the precise mechanism, but there’s evidence some of the micronutrients are associated with body metabolism in pregnancy. We have started analysing the data and we hope to be able to drill down into which component or components are most critical.”
Associate Professor Shiao Yng Chan from the National University of Singapore was a co-author on the paper. She says the effects of a mother's nutrition during pregnancy might not show in the baby right away.
“As the child grows, the things that happened in the baby's body while in the womb become apparent. These early events, sometimes called ‘foetal programming’, can influence how the child reacts to an unhealthy lifestyle, like eating lots of fatty foods and not getting enough exercise. This can make some children more likely to become overweight."
Read the full paper in BMC Medicine.