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EME Funding Committee Minutes - 25th and 26th June 2019

 

Contents

 

Date

Tuesday 25th June 2019 (Day 1)

Venue

Millennium Gloucester Hotel, Kensington, London

Present members

Professor Danny McAuley (Programme Director and Interim Chair)

Professor Eric Alton (Deputy Chair)

Dr Matthew Ahearne

Dr Louise Brown

Ms Anne-Laure Donskoy

Professor Janet Dunn

Professor Carrol Gamble

Professor Jonathan Grigg

Professor Ajit Lalvani 

Professor Gregory Lip

Professor Michael Nicholson

Mr Richard Parnell

Dr Richard Peck 

Professor John Petrie (from 2.00pm)

Professor Ruth Plummer 

Professor Steve Thornton (from 1.00pm)

Professor Mark Thursz

Professor Chris Weir

Co-Opted Committee

Members: Professor Robert Storey (By telephone at 11.50am)

Secretariat

Dr Andrew Cook

Dr Elena Harden

Miss Helen Munday

Dr Dani Preedy

Ms Susan Solomons

Apologies

Professor Bill Deakin

Professor Iain McInnes

Professor Rustam Salman

Absent DCM comments were presented at the meeting

Observers/In attendance

Alex Wilkinson, Yorkshire and The Humber, RDS

Karolina Rusiak, RDCS Wales

Vicky Taylor, Assistant Director, Application & Funding NETSCC

Dr Penny Morton, MRC

Professor John Norrie, University of Edinburgh

 

Tuesday 25th June 2019 – Day 1

Stage 2 Proposals

18/125: Researcher Led

NIHR128104: Hereditary Sensory Neuropathy Serine trial (SENSE trial)

Professor Mary Reilly

Chair: Professor Danny McAuley

Declared a conflict and left the room: Louise Brown

Arrived/left meeting: Carrol Gamble arrived at the end of the discussion and did not vote

Decision: Declined

18/86: Precision Medicine

NIHR128529: Novel blood test to personalise Early Stage Colorectal Cancer treatment

Professor David Cunningham

Chair: Professor Danny McAuley

Declared a conflict and left the room: Richard Peck

Decision: Recommended to Programme Director to consider fund with changes

18/58: Researcher Led

NIHR127461: SuSPeCT study (Stratification of Patients Suspected of Colorectal Cancer)

Professor Ramesh Arasaradnam

Chair: Professor Danny McAuley

Declared a conflict and left the room: Janet Dunn, Jonathan Grigg, Matthew Ahearne

Conflicted but not in attendance: Steve Thornton

Decision: Declined

18/125: Researcher Led

NIHR128240: Remote Ischaemic Conditioning After Stroke 3 (RECAST-3): A multicentre randomised controlled trial

Associate Professor Timothy England

Chair: Professor Danny McAuley

Declared a conflict and left the room: Chris Weir

Conflicted but not in attendance: John Petrie, Iain McInnes

Decision: Recommended to Programme Director to consider fund with changes

18/131: Urothelial Cancers

NIHR128103: Genotype of Urothelial cancer: Stratified Treatment and Oncological outcomes (GUSTO): Phase II study

Professor James Catto

Chair: Professor Danny McAuley

Declared a conflict and left the room: Andrew Cook, Richard Peck

Decision: Recommended to Programme Director to consider fund with changes

18/56: Neurodegenerative Disorders

NIHR127921: Evaluation of Triumeq as a treatment for amyotrophic lateral sclerosis: The Lighthouse 2 UK Study

Professor Ammar Al-Chalabi

Chair: Professor Danny McAuley

Declared a conflict and left the room: Jonathan Grigg

Conflicted but not in attendance: Steve Thornton

Decision: Recommended to Programme Director to consider fund with changes

18/125: Researcher Led

NIHR128445: Efficacy and mechanisms evaluation of a blood free (acellular) perfusion fluid for use in normothermic machine perfusion and transplantation of extended criteria donor livers

Professor Darius Mirza

Chair: Professor Danny McAuley

Declared a conflict and left the room: None

Arrived/left meeting: Steve Thornton and John Petrie arrived at the end of the discussion and did not vote

Decision: Declined

18/127: Transplantation

NIHR128475: Early detection of post-transplant lung allograft dysfunction by monitoring of lung clearance index

Dr Alex Horsley

Chair: Professor Danny McAuley

Declared a conflict and left the room: None

Conflicted but not in attendance: Bill Deakin

Decision: Declined

18/169: Mechanisms of Action of Health Interventions

NIHR129029: Mechanistic Evaluation of Treatments for Acute Antibody-Mediated Rejection of the Kidney Transplant

Dr Candice Roufosse

Chair: Professor Danny McAuley

Declared a conflict and left the room: Eric Alton, Ajit Lalvani, Mark Thursz, Chris Weir

Decision: Recommended to Programme Director to consider fund with changes

18/169: Mechanisms of Action of Health Interventions

NIHR129392: “OSMOTIC Study” - Investigating the mechanisms of action of hyperosmolar therapy on neurological outcomes following acute severe traumatic brain injury

Dr Matthew Rowland

Chair: Dr Andrew Cook

Iain McInnes was not present and his comments were presented on his behalf.

Declared a conflict and left the room: Danny McAuley, Janet Dunn

Decision: Declined - invited to resubmit

18/169: Mechanisms of Action of Health Interventions

NIHR128930: HABSelect2: Hyaluronan-based sperm selection, protection against male-mediated miscarriage

Dr Jackson Kirkman-Brown

Chair: Professor Danny McAuley

Iain McInnes was not present and his comments were presented on his behalf.

Declared a conflict and left the room: None

Decision: Declined

18/126: Functional Imaging

NIHR128494: Application of functional MRI to improve assessment of chronic kidney disease (AFiRM study)

Associate Professor Nicholas Selby

Chair: Professor Danny McAuley

Declared a conflict and left the room: None

Decision: Recommended to Programme Director to consider fund with changes

18/86: Precision Medicine

NIHR128465: Positioning Imatinib for Pulmonary Arterial Hypertension

Professor Martin Wilkins

Chair: Professor Danny McAuley

Declared a conflict and left the room: Eric Alton, Ajit Lalvani, Mark Thursz, Michael Nicholson, Chris Weir

Decision: Recommended to Programme Director to consider fund with changes

11/30: Researcher Led Contract Extension

11/30/07: Multi-centre Randomized Controlled Trial of angiotensin converting enzyme inhibitor (ACEi) /angiotensin receptor blocker (ARB) - withdrawal in chronic kidney disease – STOP-ACEi-STUDY (SAS)

Professor Sunil Bhandari

Chair: Professor Danny McAuley

Iain McInnes was not present and his comments were presented on his behalf.

Declared a conflict and left the room: Eric Alton, Ajit Lalvani, Mark Thursz, Matthew Ahearne

Decision: Approved

Stage 1 Proposals

18/125: Researcher Led - Resubmission

NIHR128602: Randomised Evaluation of the Effect of Atrial Fibrillation Targeted Treatment Strategies on Exercise Capacity in Heart Failure with Preserved Ejection Fraction (EASE-HFpEF) Trial

Dr Tom Wong

Chair: Professor Danny McAuley

Declared a conflict and left the room: Andrew Cook, Eric Alton, Ajit Lalvani, Mark Thursz, John Petrie

Conflicted but not in attendance: Iain McInnes

Decision: Declined

18/127: Transplantation - Resubmission

NIHR128600: PROpHET - Perfusion and Recovery Of HEarts for Transplantation

Mr Pedro Catarino

Chair: Professor Danny McAuley

Iain McInnes was not present and his comments were presented on his behalf.

Declared a conflict and left the room: Andrew Cook, Chris Weir

Conflicted but not in attendance: Bill Deakin

Decision: Declined

18/140: Frailty Themed Call

NIHR128926: Using METformin to PREVENT progression to frailty for older people (MET-PREVENT) – a randomised controlled trial

Professor Miles Witham

Chair: Professor Danny McAuley

Declared a conflict and left the room: Ruth Plummer, Chris Weir

Decision: Declined

 

Date

Wednesday 26th June 2019 (Day 2)

Venue

Millennium Gloucester Hotel, Kensington, London

Present members

Professor Danny McAuley (Programme Director and Interim Chair)

Professor Eric Alton (Deputy Chair)

Dr Matthew Ahearne

Dr Louise Brown

Professor Bill Deakin

Ms Anne-Laure Donskoy

Professor Janet Dunn

Professor Carrol Gamble

Professor Jonathan Grigg

Professor Ajit Lalvani

Professor Gregory Lip

Professor Iain McInnes

Professor Michael Nicholson (left at 3.00pm)

Mr Richard Parnell

Dr Richard Peck

Professor John Petrie

Professor Ruth Plummer

Professor Steve Thornton

Professor Mark Thursz

Professor Chris Weir

Secretariat

Dr Andrew Cook

Dr Elena Harden

Miss Helen Munday

Dr Dani Preedy

Ms Susan Solomons

Apologies

Professor Rustam Salman

Observers/In attendance

Dr Penny Morton, MRC

Helen Risebro, RDS

Phillip Pallmann, RDCS, Wales

 

 

Wednesday 26th June 2019 – Day 2

Stage 1 Proposals

18/141: Chronic Pain Themed Call

NIHR128682: NAvigation guided transcranial MAgnetic STimulation for chronic cEntral post stroke pain (NAMASTE). A randomised double blind sham controlled clinical trial.

Dr Bernhard Frank

Chair: Professor Danny McAuley

Declared a conflict and left the room: Iain McInnes, Carrol Gamble, Gregory Lip

Decision: Declined

18/141: Chronic Pain Themed Call

NIHR129335: The Efficacy of Dorsal Root Ganglion Burst Stimulation in the Management of Complex Regional Pain Syndrome. A Multicentre, Randomised Double-Blind Sham-Controlled Study. “Typhoon”

Dr Adnan Al-Kaisy

Chair: Professor Danny McAuley

Declared a conflict and left the room: Andrew Cook, Louise Brown, Carrol Gamble, Gregory Lip

Arrived/left meeting: Ajit Lalvani arrived at the end of the discussion and did not vote.

Decision: Shortlisted

18/168: Precision Medicine

NIHR129046: [18F]FDOPA-PET IMAGING AS A BIOMARKER FOR TREATMENT STRATIFICATION IN PSYCHOSIS

Dr Mattia Veronese

Chair: Professor Danny McAuley

Declared a conflict and left the room: Bill Deakin

Decision: Declined - invited to resubmit

18/168: Precision Medicine

NIHR128718: Withdrawal of Immunosuppression in lupus Nephritis trial: The WIN trial

Dr Michael Robson

Chair: Professor Danny McAuley

Declared a conflict and left the room: None

Decision: Declined

18/168: Precision Medicine

NIHR129203: Improved non-invasive diagnostic assessment and monitoring of non alcoholic steatohepatitis (NASH):The IMPROVISE study

Professor Chris Byrne

Chair: Professor Danny McAuley

Declared a conflict and left the room: Phillip Pallman (observer)

Decision: Declined

18/168: Precision Medicine

NIHR129219: Investigation of genetic susceptibility to retinal toxicity in patients taking Hydroxychloroquine

Associate Professor Susan Downes

Chair: Professor Danny McAuley

Declared a conflict and left the room: None

Decision: Declined

18/168: Precision Medicine

NIHR129023: Optimising Psoriatic Arthritis Therapy with Immunological Methods to Increase Standard Evaluation (OPTIMISE)

Dr Laura Coates

Chair: Professor Danny McAuley

Declared a conflict and left the room: Iain McInnes, John Petrie

Decision: Shortlisted

18/168: Precision Medicine

NIHR128878: Precision RnA Guided Management of TuberculosIs Contacts (PRAGMATIC) 1

Professor Mahdad Noursadeghi

Chair: Professor Danny McAuley

Declared a conflict and left the room: Louise Brown, Eric Alton, Ajit Lalvani, Mark Thursz

Decision: Declined – invited to resubmit

18/170: Researcher Led

NIHR128981: HYDRation and urinary Alkalinisation to prevent renal injury after endovascular aortic intervention: the HYDRA randomised controlled trial

Mr Athanasios Saratzis

Chair: Professor Danny McAuley

Declared a conflict and left the room: Matthew Ahearne, Janet Dunn

Decision: Declined

18/168: Precision Medicine

NIHR129268: A biomarker stratified randomized trial of chemotherapy plus cetuximab or panitumumab, versus chemotherapy alone, in the first-line treatment of RAS wild-type advanced colorectal cancer with a right-sided primary tumour location

Dr Jenny Seligmann

Chair: Professor Danny McAuley

Declared a conflict and left the room: Phillip Pallman (observer), Louise Brown, Iain McInnes

Decision: Shortlisted

18/168: Precision Medicine

NIHR128816: Risk stratification of patients with compensated liver cirrhosis for oesophageal varices needing treatment using MRI

Dr Michael Pavlides

Chair: Professor Danny McAuley

Declared a conflict and left the room: None

Decision: Shortlisted

18/170: Researcher Led

NIHR129389: Beta-blocker Efficacy Assessment using MRI in Guiding Therapy of Varices (BEAMinG)

Professor Guruprasad Aithal

Chair: Professor Danny McAuley

Declared a conflict and left the room: Louise Brown, Chris Weir

Arrived/left meeting: Ajit Lalvani left the room at the start of the discussion.

Decision: Declined

18/172: Benign Gynaecological Disorders

NIHR129283: UCON2 - Ulipristal acetate versus CONventional medical treatment in women (of reproductive age) with heavy menstrual bleeding due to adenomyosis

Professor Hilary Critchley

Chair: Professor Danny McAuley

Declared a conflict and left the room: Phillip Pallmann (observer), Chris Weir

Arrived/left meeting: Ajit Lalvani returned to the room at the start of the discussion.

Decision: Declined - invited to resubmit

18/172: Benign Gynaecological Disorders

NIHR128827: PurFECT2: A multicentre randomised double-blind placebo-controlled trial to evaluate the efficacy of Omega-3 polyunsaturated fatty acids in the management of endometriosis-associated pain in women

Professor Andrew Horne

Chair: Professor Danny McAuley

Declared a conflict and left the room: Chris Weir, Richard Peck

Decision: Declined

19/17: Digital Technologies to Improve Health and Care

NIHR129493: Touch and Image Guided Robotic Surgery (TIGERS): An internal pilot study and randomised trial with economic evaluation to compare the use of prostate MRI derived 3D printed models during robotic assisted radical prostatectomy to improve outcomes

Professor Prokar Dasgupta

Chair: Professor Danny McAuley

Declared a conflict and left the room: Eric Alton, Ajit Lalvani, Mark Thursz, Ruth Plummer

Decision: Declined

18/158: Cannabis-based products for medicinal use themed call

NIHR129384: CASCADE: CAnnabidiol for Smoking Cessation in generalised Anxiety DisordEr

Professor Celia Morgan

Chair: Professor Danny McAuley

Declared a conflict and left the room: Louise Brown, Steve Thornton

Decision: Declined

18/170: Researcher Led

NIHR129318: Home-based EXercise and motivAtional program before and after Liver Transplantation: ExaLT trial

Dr Matthew Armstrong

Chair: Professor Danny McAuley

Declared a conflict and left the room: Louise Brown

Decision: Shortlisted

18/170: Researcher Led

NIHR129340: Double blind comparison of optimised Deep Brain Stimulation for severe Tourette syndrome

Professor Patricia Limousin

Chair: Professor Danny McAuley

Declared a conflict and left the room: Louise Brown

Decision: Declined - invited to resubmit

18/170: Researcher Led

NIHR129451: PROgenitor Cell Expansion and Steroids in Severe Alcoholic Hepatitis (PROCESSAH)

Professor Stephen Ryder

Chair: Professor Danny McAuley

Declared a conflict and left the room: Eric Alton, Ajit Lalvani, Mark Thursz, Michael Nicholson, Iain McInnes, John Petrie

Decision: Declined

18/170: Researcher Led

NIHR129325: Improving treatment of glioblastoma: validating the efficacy of a machine learning model to detect pseudoprogression

Dr Thomas Booth

Chair: Professor Danny McAuley

Declared a conflict and left the room: None

Arrived/left meeting: Steve Thornton left the room at the start of the discussion.

Decision: Declined

18/170: Researcher Led

NIHR129407: Woven EndoBridge safety Compared to Alternative Management for treatment of wide-neck bifurcation aneurysms (WEBCAM)

Dr Thomas Booth

Chair: Professor Danny McAuley

Declared a conflict and left the room: Ruth Plummer

Arrived/left meeting: Steve Thornton returned to the room for the start of this discussion.

Decision: Declined

18/170: Researcher Led

NIHR129476: Culture media UK: impact on offspring conceived through in-vitro fertilisation

Dr Abha Maheshwari

Chair: Professor Danny McAuley

Declared a conflict and left the room: Phillip Pallmann (observer), Bill Deakin

Decision: Declined

18/171: Dental Health - Disorders of the teeth and gums

NIHR129163: Can a near infrared light transillumination device be used to accurately detect caries in a general dental practice setting?

Professor Tanya Walsh

Chair: Professor Danny McAuley

Declared a conflict and left the room: Bill Deakin

Decision: Shortlisted

18/171: Dental Health - Disorders of the teeth and gums

NIHR129218: The efficacy of different treatment strategies in the regeneration of furcation defects in periodontitis. A single-blind randomised controlled non-inferiority trial with mechanistic sub-study

Professor Nikolaos Donos

Chair: Professor Danny McAuley

Declared a conflict and left the room: Jonathan Grigg, Steve Thornton, Louise Brown, Chris Weir

Decision: Declined

18/167: End of Life Care

NIHR129411: Investigation of changes in volatile organic compounds towards the end of life in patients with breast, colorectal or prostate cancer

Dr Seamus Coyle

Chair: Professor Danny McAuley

Declared a conflict and left the room: Carrol Gamble, Gregory Lip

Decision: Declined

18/170: Researcher Led

NIHR129244: STOP-POUCHITIS - A randomised controlled trial of faecal microbiota transplantation for pouchitis

Mr Andrew Beggs

Chair: Professor Danny McAuley

Declared a conflict and left the room: Iain McInnes, John Petrie, Mark Thursz

Arrived/left meeting: Bill Deakin left the room at the start of the discussion.

Decision: Declined

18/170: Researcher Led

NIHR128778: Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis; a randomised placebo controlled trial (BLIPA; Bacterial Lysate in Preventing Asthma)

Professor Jonathan Grigg

Chair: Dr Andrew Cook

Declared a conflict and left the room: Danny McAuley, Jonathan Grigg, Steve Thornton, Chris Weir, Carrol Gamble, Gregory Lip

Decision: Declined – invited to resubmit

18/170: Researcher Led

NIHR128948: The Efficacy and Mechanism Evaluation of Simvastatin as adjuvant therapy for Community Acquired Pneumonia on Outcomes in Older Patients with Pneumonia (EME-SNOOPI)

Dr Jaimin Patel

Chair: Professor Eric Alton

Declared a conflict and left the room: Danny McAuley, Chris Weir

Decision: Declined

18/170: Researcher Led

NIHR128918: Pioneering imaging techniques for optimising dose delivery in post-operative prostate radiotherapy (The PINPOINT study)

Dr Emma Harris

Chair: Professor Danny McAuley

Declared a conflict and left the room: None

Decision: Declined

18/170: Researcher Led

NIHR128995: Open label efficacy and mechanism Phase II basket trial of multiple sequential randomised single agents permissive for rare cancers of unmet need (RareCan1)

Professor Andrew Hassan

Chair: Professor Danny McAuley

Declared a conflict and left the room: Chris Weir, Louise Brown

Conflicted but not in attendance: Bill Deakin

Arrived/left the meeting: Michael Nicholson left the meeting at the beginning of the discussion

Decision: Declined

18/170: Researcher Led

NIHR129265: Dietary antioxidant defence (DAD) study: a double blind randomised trial of Impryl® for male infertility to improve natural conception and live birth rate

Dr Sarah Martins da Silva

Chair: Professor Danny McAuley

Declared a conflict and left the room: Phillip Pallman (observer), Chris Weir, Iain McInnes, John Petrie

Decision: Declined – invited to resubmit

18/170: Researcher Led

NIHR129382: Neoadjuvant chemotherapy (Gemcitabine & Cisplatin vs. Cabazitaxel & Cisplatin) with or without immunotherapy (Cemiplimab) for muscle invasive bladder cancer (MIBC): a factorial randomised controlled trial (RCT) with internal pilot

Professor Amit Bahl

Chair: Professor Danny McAuley

Declared a conflict and left the room: Iain McInnes

Conflicted but not in attendance: John Petrie, Bill Deakin

Arrived/left the room: Ajit Lalvani and John Petrie left the meeting at the start of the discussion

Decision: Shortlisted

18/170: Researcher Led

NIHR128980: Using kisspeptin to trigger oocyte maturation to improve the safety of IVF treatment

Professor Waljit Dhillo

Chair: Professor Danny McAuley

Declared a conflict and left the room: Eric Alton, Mark Thursz

Conflicted but not in attendance: Ajit Lalvani

Decision: Shortlisted

18/170: Researcher Led

NIHR128426: An evaluation of the effect of Therapeutic Targeted Temperature in brain dead organ donors on donor kidney function at 12 months post-transplantation: the 3T study

Professor Christopher Watson

Chair: Professor Danny McAuley

Declared a conflict and left the room: None

Conflicted but not in attendance: Michael Nicholson

Decision: Declined