Meeting
EME Programme - Funding Committee Meeting
Date
Tuesday 23rd June and Wednesday 24th June 2020
Place
Virtual Meeting
Present
Professor Danny McAuley (Programme Director -does not vote)
Professor John Norrie (Programme Chair -does not vote)
Professor Eric Alton
Dr Louise Brown
Dr Victoria Cornelius
Ms Anne-Laure Donskoy (public contributor)
Professor Janet Dunn
Professor Daniel Freeman
Dr Amy Gillespie
Professor Jonathan Grigg
Mr Allen Knight (public contributor)
Professor Gregory Lip
Professor Iain McInnes
Professor Michael Nicholson
Dr Richard Peck
Professor John Petrie
Professor Ruth Plummer
Professor Rustam Salman
Dr Manu Shankar-Hari
Professor John Simpson
Professor Stuart Taylor
Professor Mark Thursz
Professor Chris Weir
Secretariat
Dr Andrew Cook
Mrs Julie Daniels
Dr Elena Harden
Miss Helen Munday
Dr Dani Preedy
Ms Susan Solomons
Apologies
Professor Arri Coomarasamy
Professor Alastair Hay
Dr Penny Morton, MRC
Observers
Dr Mildred Iro
Professor Andrew Farmer
Dr Ksenia Kurbatskaya, Research on Research, NETSCC
Alex Phillips, MRC
Adam Babbs, MRC
Day 1
Stage 2 Proposals
19/100 EME Researcher Led
NIHR130797 Pandit
Mechanically Aligned total knee Replacement Vs KinEmatically Aligned total Knee Replacement (MARKER)
Chair: Professor John Norrie
Declared a conflict : N/A
Left the discussion: Professor Iain McInnes left the discussion after the vote
Decision: Declined
NIHR130628 Allen
Can the diagnostic accuracy of newborn eye screening for congenital cataract be improved with digital dual wavelength imaging? The Ophthalmoscope vs Imaging Device (OvID) study.
Chair: Professor John Norrie
Declared a conflict: Professor Chris Weir
Decision: Recommended to Programme Director to consider fund with changes
19/24 EME Researcher Led
NIHR129819 Steve Turner
SPIROMAC – SPIROmetry to Manage Asthma in Children
Chair: Professor Danny McAuley
Declared a conflict: Professor John Norrie, Professor Jonathan Grigg
Decision: Recommended to Programme Director to consider fund with changes
18/170 EME Researcher Led
NIHR128778 Grigg
Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis; a randomised placebo controlled trial (BLIPA; Bacterial Lysate in Preventing Asthma)
Chair: Dr Andrew Cook
Declared a conflict: Professor Danny McAuley, Professor John Norrie, Professor Chris Weir, Professor Jonathan Grigg
Decision: Recommended to Programme Director to consider fund with changes
19/100 EME Researcher Led
NIHR131157 Qurashi
GOTHIC2: A multi-centre randomised placebo-controlled trial of glycopyrrolate and hyoscine hydrobromide for the treatment of clozapine-induced hypersalivation
Chair: Professor John Norrie
Declared a conflict: Dr Amy Gillespie, Professor Gregory Lip
Decision: Declined – invited to resubmit
NIHR130966 Twelves
PROgesterone as a Steroid SParing agent against oEdema occurring during primary/secondary bRain cancer treatment
Chair: Professor John Norrie
Declared a conflict: N/A
Decision:Recommended to Programme Director to consider fund with changes
Stage 1 Proposal
19/144 EME Perinatal Mental Health
NIHR131161 Hirsch
A randomised controlled trial to evaluate the outcomes and mechanism of a web-based intervention to prevent perinatal anxiety
Chair: Professor Eric Alton
Declared a conflict: Dr Manu Shankar-Hari, Professor Janet Dunn, Professor John Norrie
Decision: Shortlisted
Stage 2 proposals
19/61 Mitigation of the adverse effects of health and social care interventions
NIHR130331 Drobniewski
PROtecting Hearing during Antimicrobial therapy using N-acetylcysteine - a double-blind randomised controlled trial (PROHAN)
Chair: Professor John Norrie
Declared a conflict: Dr Andrew Cook, Professor Eric Alton, Professor Jonathan Grigg
Decision: Declined
19/149 EME Solid Organ Replacement, Transplant And Donation
NIHR131163 Friend
Defatting of donor transplant livers during normothermic perfusion – a pilot randomised clinical trial
Chair: Professor John Norrie
Declared a conflict: Professor Andrew Farmer, Professor Michael Nicholson
Decision: Recommended to Programme Director to consider fund with changes
19/141 EME Liver Disease
NIHR130730 Shawcross
A PROspective double-blind placebo-controlled multicentre trial of faecal MIcrobiota tranSplantation to improve outcomEs in patients with cirrhosis - PROMISE trial
Chair: Professor John Norrie
Declared a conflict: Dr Manu Shankar-Hari, Professor Eric Alton, Dr Victoria Cornelius, Professor Mark Thursz
Decision: Recommended to Programme Director to consider fund with changes
19/99 Mechanisms of Action of Health Interventions
NIHR130938 Alice Turner
Airway microbiome driven mechanisms of disease after optimised self management: Colour-COPD trial
Chair: Professor John Norrie
Declared a conflict and did not participate in the discussion: Dr Andrew Cook, Dr Mildred Iro, Professor Gregory Lip
Left the discussion after the vote: Dr Amy Gillespie
Decision: Recommended to Programme Director to consider fund with changes
19/119 Mechanisms of Action of Health Interventions
NIHR131450 Robson
Changes in circulating monocytes after treatment of arteriovenous fistulas with paclitaxel-coated or plain angioplasty balloons
Chair: Professor John Norrie
Declared a conflict: Dr Manu Shankar-Hari
Decision: Declined
NIHR131332 Holliday
The ENHANCE-D Study – ENHANCing smoking cEssation interventions in Dentistry
Chair: Dr Andrew Cook
Declared a conflict: Professor Chris Weir, Professor John Norrie, Professor John Simpson, Professor Rustam Salman, Professor Ruth Plummer
Decision: Declined
NIHR131600 Scott
Efficacy and Mechanism Evaluation - Effectiveness of Electronic Cigarettes compared with varenicline for smoking cessation in patients with COPD and effect on the Lungs (EME-ECAL study)
Chair: Professor John Norrie
Declared a conflict: Professor Danny McAuley
Joined for the start of the discussion: Professor Iain McInnes
Decision: Declined - invited to resubmit
NIHR131575 Lewis
Evaluating treatment response mechanisms of Rituximab and Tocilizumab in Rheumatoid Arthritis in the R4RA randomised clinical trial
Chair: Professor John Norrie
Declared a conflict: Dr Richard Peck, Professor Jonathan Grigg
Decision: Declined - invited to resubmit
Stage 1 Proposals
19/138 EME Researcher Led
NIHR131368 Wickham
Early Vitrectomy vs Laser Treatment for Proliferative Diabetic Retinopathy (Acronym: EVERLAST-PDR): A Multi-Centre Prospective Clinical Trial
Chair: Professor John Norrie
Declared a conflict: N/A
Decision: Declined
NIHR131082 Murray
APPROACH: Analysis of Proton vs. Photon Radiotherapy in Oligodendroglioma and Assessment of Cognitive Health
Chair: Professor John Norrie
Declared a conflict: N/A
Decision: Shortlisted
NIHR131326 Lunn
A randomised controlled trial to measure the clinical and cost-effectiveness of Therapeutic Rituximab in patients with active, IVIg-dependent, Chronic Inflammatory Demyelinating Polyradiculoneuropathy: The TRIC Study
Chair: Professor John Norrie
Declared a conflict: Dr Louise Brown, Dr Richard Peck, Professor Andrew Farmer
Left the discussion after the vote: Dr Manu Shankar-Hari
Decision: Declined
18/168 EME Precision Medicine
NIHR129046 Veronese
[18F]FDOPA-PET IMAGING AS A BIOMARKER FOR TREATMENT STRATIFICATION IN PSYCHOSIS
Chair: Professor John Norrie
Declared a conflict and did not participate in the discussion: Dr Manu Shankar-Hari
Left the discussion after the vote: Professor Mark Thursz
Decision: Declined
19/149 EME Solid Organ Replacement, Transplant and Donation
NIHR130899 Giele
Effectiveness and mechanism of sentinel skin flap reduction of solid organ transplant rejection
Chair: Professor John Norrie
Declared a conflict: Professor Eric Alton, Dr Richard Peck, Professor Andrew Farmer
Decision: Shortlisted
Outcomes Table
Stage 2 Proposals
The EME Funding Committee recommended the following Stage 2 proposals for either immediate funding or for funding subject to certain conditions
Commissioned
| Project Reference | Lead Applicant | Institution | Project Title |
|---|---|---|---|
| NIHR130730 | Professor Debbie Shawcross | King's College London | A PROspective double-blind placebo-controlled multicentre trial of faecal MIcrobiota tranSplantation to improve outcomEs in patients with cirrhosis - PROMISE trial |
| NIHR130938 | Professor Alice Turner | University of Birmingham | Airway microbiome driven mechanisms of disease after optimised self management: Colour-COPD trial |
| NIHR131163 | Professor Peter Friend | University of Oxford | Defatting of donor transplant livers during normothermic perfusion – a pilot randomised clinical trial |
Researcher Led
| Project Reference | Lead Applicant | Institution | Project Title |
|---|---|---|---|
| NIHR130628 | Dr Louise Allen | Cambridge University Hospitals NHS Foundation Trust | Can the diagnostic accuracy of newborn eye screening for congenital cataract be improved with digital dual wavelength imaging? The Ophthalmoscope vs Imaging Device (OvID) study |
| NIHR129819 | Professor Steve Turner | University of Aberdeen | SPIROMAC – SPIROmetry to Manage Asthma in Children |
| NIHR128778 | Professor Jonathan Grigg | Queen Mary University of London | Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis; a randomised placebo controlled trial (BLIPA; Bacterial Lysate in Preventing Asthma) |
| NIHR130966 | Professor Chris Twelves | Public Health Scotland | PROgesterone as a Steroid SParing agent against oEdema occurring during primary/secondary bRain cancer treatment |
Further information on the above projects will be provided on the EME website once the project has started.
Stage 1 Proposals
The following Stage 1 proposals have been shortlisted to submit a Stage 2 application for consideration by the EME Funding Committee at its next meeting
Researcher Led
| Project Reference | Lead Applicant | Institution | Project Title |
|---|---|---|---|
| NIHR131082 | Dr Louise Murray | University of Leeds | APPROACH: Analysis of Proton vs. Photon Radiotherapy in Oligodendroglioma and Assessment of Cognitive Health |
Commissioned
| Project Reference | Lead Applicant | Institution | Project Title |
|---|---|---|---|
| NIHR131161 | Dr Colette Hirsch | King's College London | A randomised controlled trial to evaluate the outcomes and mechanism of a web-based intervention to prevent perinatal anxiety |
| NIHR130899 | Associate Professor Henk Giele | University of Oxford | Effectiveness and mechanism of sentinel skin flap reduction of solid organ transplant rejection |