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HTA Funding Committee Public Minutes 12-13 March 2019

 

Contents

Day 1 - 12 March 2019

Venue:

Millennium Gloucester Hotel, London

Present members:

Professor Lucy Chappell (Chair), Professor Julia Brown (Deputy Chair), Professor Hywel Williams (HTA Programme Director), Ms Gail Thornton (PPI representative), Mrs Deborah Keatley (PPI representative), Professor Tim Coleman, Professor Paul Ewings,  Professor Edwin Van Teijlingen,  Professor William Hollingworth, Professor Daniel Lasserson, Dr Susan Jowett, Dr Kate Brown, Professor Richard Emsley, Professor Daniel Prieto-Alhambra, Professor Scott Weich, Professor Peter Langhorne, Dr Kathryn Radford, Professor Alan Montgomery, Professor Athanasios Saratzis, Professor Steph Taylor, Dr Jennifer Logue, Mr Thomas Pinkney, Dr Charlotte Coles, Dr David Ekers, Dr Sharon Simpson, Professor Rebecca Kearney, Professor Sally Hopewell (New Committee Member)

NETSCC, HTA Secretariat

Dr Martin Ashton-Key (Consultant Advisor, NETSCC), Mrs Karen Williams (Senior Research Manager), Dr Cristina Lujan Barroso (Research Manager),  Mr Alan Newman (Assistant Research Manager)

Apologies 

Professor Douglas Tincello

Observers

Tricia Ellis – James Lind Alliance

Quoracy Information 

Voting members: 26 Quorum = 17
Voting members present on Day 1: 25 (96%) 

Commissioned Stage 2 Proposals

18/37 Repair of digital nerve injury

Chair: Lucy Chappell
Declared a conflict and left the room: Sally Hopewell, Jennifer Logue, Kathryn Radford, Alan Montgomery, Daniel Prieto-Alhambra

NIHR127807:  Repair of digital nerve injury (Associate Professor Abhilash Jain, University of Oxford)

Funding Committee recommendation: Programme Oversight Committee (POC) to consider fund with changes

18/39 Earlier active management of ovarian hyperstimulation syndrome

Chair: Julia Brown
Declared a conflict and left the room: Hywel Williams, Scott Weich, Sharon Simpson

NIHR128137: STOP-OHSS (Shaping and Trialling Outpatient Protocols for Ovarian Hyper-Stimulation Syndrome): A feasibility study and randomised controlled trial, with internal pilot, to assess the clinical and cost-effectiveness of earlier active management of OHSS (Mr Mostafa Metwally, Sheffield Teaching Hospitals NHS Foundation Trust)

Funding Committee recommendation: Programme Oversight Committee (POC) to consider fund with changes

18/41 Clinical and cost effectiveness of alternative catheter design at preventing catheter-associated urinary tract infection

Chair: Julia Brown
Declared a conflict and left the room: Martin Ashton Key

NIHR127864: Multicentre trial of the clinical and cost effectiveness of two novel urinary catheter designs in preventing catheter-associated urinary tract infection compared with the traditional Foley design for adults requiring long-term catheterisation (CADET) (Dr Catherine Murphy, University of Southampton>

Funding Committee recommendation: Decline Return to POC

18/43 Rotation of the fetal head at full cervical dilatation

Chair: Martin Ashton-Key
Declared a conflict and left the room: Rebecca Kearney, Jennifer Logue, Susan Jowett, Athanasios Saratzis, Thomas Pinkney, Hywel Williams, Julia Brown, Lucy Chappell, Sharon Simpson, Stephanie Taylor

NIHR127266: ManuAl verSuS InStrumental roTation: ASSIST trial (Professor Fiona Denison, The University of Edinburgh)

Funding Committee recommendation: Decline Return to POC

NIHR127818: ROTATE. Rotation of the fetal head at full cervical dilatation (Associate Professor Dimitrios Siassakos, UCL Institute for Women’s Health

Funding Committee recommendation: Decline Return to POC

18/52 Management of isolated or incidental subsegmental pulmonary embolism

Chair: Lucy Chappell
Declared a conflict and left the room: Susan Jowett, Thomas Pinkney, Daniel Lasserson

NIHR128073: Stopping anticoagulation for isolated or incidental sub-segmental pulmonary embolism (STOPAPE) (Professor Daniel Lasserson, University of Birmingham)

Funding Committee recommendation: Programme Oversight Committee (POC) to consider fund with changes

17/147 Researcher-Led Primary Research Stage 2 Proposals

17/147/22: Probiotics to prevent recurrent urinary tract infections in women (POPPY): a multicentre placebo-controlled individually randomised superiority trial (Professor Alastair Hay, University of Bristol)

Chair: Lucy Chappell
Declared a conflict and left the room: Gail Thornton, Alan Montgomery, Daniel Lasserson, Hywel Williams, Paul Ewings, William Hollingworth
Proposal outcome: Decline*

*Decision made by the Programme Oversight Committee (POC)

NIHR127291: A randomised controlled trial of intra-operative mannitol for the prevention of delayed graft function in deceased donor renal transplant (IMPART) (Mr Adam Barlow, Leeds Teaching Hospitals NHS Trust)

Chair: Lucy Chappell
Declared a conflict and left the room: Julia Brown
Left meeting: Deborah Keatley
Funding Committee recommendation: Decline 

17/147/52: A multicentre randomised pragmatic trial to evaluate the effectiveness of MT in improving the quality of life of hospice inpatients, and the impact on those close to them(Professor Sam Porter, Bournemouth University)

Chair: Julia Brown
Declared a conflict and left the room: Edwin van Teijlingen, Lucy Chappell, Paul Ewings
Arrived meeting: Deborah Keatley
Funding Committee recommendation: Decline

NIHR128058: Safety of antidepressants in older people with depression or anxiety disorder and comorbid diabetes, heart disease or stroke - population based cohort studies (Professor Carol Coupland, The University of Nottingham)

Chair: Lucy Chappell
Declared a conflict and left the room: Jennifer Logue, Kathryn Radford, Alan Montgomery, Hywel Williams, Tim Coleman
Funding Committee recommendation: Decline

NIHR127547: A Randomised Multiple Centre Trial of Conservative versus Liberal Oxygenation Targets in Critically Ill Children (Oxy-PICU) (Professor Mark Peters, University College London)

Chair: Julia Brown
Declared a conflict and left the room: Katherine Brown
Left meeting: Daniel Prieto Alhambra
Funding Committee recommendation: Programme Oversight Committee (POC) to consider fund with changes

NIHR128086: A randomised controlled trial of Paramedic Analgesia Comparing Ketamine and MorphiNe in trauma (PACKMaN) (Dr Michael Smyth, University of Warwick)

Chair: Julia Brown
Declared a conflict and left the room: Rebecca Kearney, Daniel Lasserson, Scott Weich, Athanasios Saratzis
Left meeting: Gail Thornton
Funding Committee recommendation: Programme Oversight Committee (POC) to consider fund with changes

NIHR127714: Preventing late miscarriage or preterm delivery by screening and treating pregnant women for vaginal infections: a multicentre randomised controlled trial (Professor Pippa Oakeshott, St George's, University of London)

Chair: Julia Brown
Declared a conflict and left the room: Lucy Chappell
Arrived meeting: Gail Thornton
Funding Committee recommendation: Decline

NIHR127817: The HUmeral SHaft fracture trial (HUSH) (Mr Stephen Gwilym, University of Oxford)

Chair: Lucy Chappell
Declared a conflict and left the room: Rebecca Kearney, Sally Hopewell, Alan Montgomery
Funding Committee recommendation: Programme Oversight Committee (POC) to consider fund with changes

NIHR127393: Hand-2: Needle fasciotomy versus limited fasciectomy for treatment of Dupuytren’s contractures of fingers: a randomised non-inferiority trial with an individual participant data network meta-analysis comparison with DISC (ISRCTN18254597) to compare outcomes after collagenase injections (Honorary Professor Tim Davis, Nottingham University Hospitals NHS Trust)

Chair: Lucy Chappell
Declared a conflict and left the room: Sally Hopewell, Kathryn Radford, Alan Montgomery, Hywel Williams, Paul Ewings, Sharon Simpson, Tim Coleman, William Hollingworth
Funding Committee recommendation: Programme Oversight Committee (POC) to consider fund with changes
 

NIHR127767: Trial Of PostoperatIve Cryotherapy AppLication (TOPICAL) (Mr Peter Wall, University of Warwick)

Chair: Lucy Chappell
Declared a conflict and left the room: Rebecca Kearney, Jennifer Logue, Kathryn Radford, Scott Weich
Funding Committee recommendation: Decline

NIHR128156: Pragmatic randomised controlled trial of clinical effectiveness and cost-effectiveness of methoxyflurane for the treatment of acute traumatic prehospital pain (Dr Matthew Wilson, The University of Sheffield)
 

Chair: Julia Brown
Declared a conflict and left the room: Scott Weich
Funding Committee recommendation: Decline

NIHR127976: Perinatal and 2 year neurodevelopmental outcome in late preterm fetal compromise: the TRUFFLE 2 Randomised Trial (Professor Christoph Lees, Imperial College London)

Chair: Julia Brown
Declared a conflict and left the room: Alan Montgomery, Hywel Williams, Lucy Chappell, Sharon Simpson
Funding Committee recommendation: Programme Oversight Committee (POC) to consider fund with changes
Summing Up

Day 2- 13 March 2019 

Venue:

Millennium Gloucester Hotel, London

Present members 

Professor Lucy Chappell (Chair), Professor Julia Brown (Deputy Chair), Professor Hywel Williams (HTA Programme Director), Ms Gail Thornton (PPI representative), Mrs Deborah Keatley (PPI representative), Professor Tim Coleman, Professor Paul Ewings,  Professor Edwin Van Teijlingen,  Professor William Hollingworth, Professor Daniel Lasserson, Dr Susan Jowett, Professor Richard Emsley, Professor Scott Weich, Professor Peter Langhorne, Dr Kathryn Radford, Professor Alan Montgomery, Professor Athanasios Saratzis, Professor Steph Taylor, Dr Jennifer Logue, Mr Thomas Pinkney, Dr Charlotte Coles, Dr David Ekers, Dr Sharon Simpson, Professor Rebecca Kearney, Professor Sally Hopewell (New Committee Member)

NETSCC, HTA Secretariat 

Dr Martin Ashton-Key (Consultant Advisor, NETSCC), Mrs Karen Williams (Senior Research Manager), Dr Cristina Lujan Barroso (Research Manager), Mr Alan Newman (Assistant Research Manager)

Apologies

Dr Kate Brown, Professor Daniel Prieto-Alhambra, Professor Douglas Tincello

Observers

None

Quoracy Information

Voting members: 26 Quorum = 17
Voting members present on Day 1: 22 (85%)

Commissioned Stage 1 Proposals

18/95 Rivastigmine for psychotic symptoms associated with Parkinson’s disease

Chair: Julia Brown
Declared a conflict and left the room: Kathryn Radford, David Ekers, Lucy Chappell, Paul Ewings, Richard Emsley, William Hollingworth

NIHR128805: What is the clinical and cost-effectiveness of rivastigmine compared with antipsychotic drug treatment for treating psychotic symptoms associated with Parkinson's disease? (Dr Dominic ffytche, Institute of Psychiatry, Psychology & Neuroscience, King's College London) 

Funding Committee recommendation: Decline Return to POC

18/96 Hormone therapy for premature ovarian insufficiency

Chair: Julia Brown
Declared a conflict and left the room: Jennifer Logue, Kathryn Radford, Alan Montgomery, Hywel Williams, Lucy Chappell, Peter Langhorne, Tim Coleman, Deborah Keatley

NIHR128757: Hormone therapy for premature ovarian insufficiency: randomised trial and long-term evaluation (Dr Melanie Davies, University College London Hospitals NHS Foundation Trust)

Funding Committee recommendation: Shortlist

18/135 Nebulised saline in patients with COPD

Chair: Lucy Chappell
Declared a conflict and left the room: Thomas Pinkney, Daniel Lasserson

NIHR128891: Nebulised saline in patients with COPD (Dr Alice Turner (nee Wood), University of Birmingham)
Funding Committee recommendation: Decline

NIHR128443: What is the clinical effectiveness and cost-effectiveness of nebulised saline in patients with chronic obstructive pulmonary disease (MucAct COPD Trial)? (Professor Adam Hill, NHS Education for Scotland)
Funding Committee recommendation: Shortlist 

18/97 Hysteroscopic removal of uterine cavity abnormalities to improve fertility

Chair: Julia Brown
Declared a conflict and left the room: Athanasios Saratzis, Thomas Pinkney, Daniel Lasserson, Hywel Williams, Lucy Chappell, Scott Weich

NIHR128979: Hysteroscopic removal of uterine cavity abnormalities to improve fertility (Professor T Justin Clark, Birmingham Women's NHS Foundation Trust)
 Funding Committee recommendation: Shortlist

NIHR128969: HELP Infertility (Hysteroscopic Excision of Leiomyoma and Polyp in Infertility): two randomised controlled trials (Mr Mostafa Metwally, Sheffield Teaching Hospitals NHS Foundation Trust)
 Funding Committee recommendation: Shortlist 

18/133 Researcher-Led primary Research Stage 1 Proposals

NIHR128543: Non-invasive CT coronary angiography versus standard invasive coronary angiography to guide the management of patients with angina: a randomised, sham-controlled, multicentre trial. (Professor Colin Berry, University of Glasgow)

Chair: Lucy Chappell
Declared a conflict and left the room: Jennifer Logue, Peter Langhorne
Arrived meeting: Susan Jowett
Funding Committee recommendation: Decline

NIHR128653: Improving the wellbeing of mothers through early recognition and treatment of bleeding after childbirth: Obstetric Bleeding Study 3 (OBS3) (Professor Peter Collins, Cardiff University)

Chair: Julia Brown
Declared a conflict and left the room: Jennifer Logue, Athanasios Saratzis, Sharon Simpson
Funding Committee recommendation: Shortlist

NIHR128162: Exercise aNd Rehabilitation In Coronary Heart disease (EnRICH) trial (Dr Gordon McGregor, University Hospitals Coventry & Warwickshire NHS Trust)

Chair: Lucy Chappell
Declared a conflict and left the room: Rebecca Kearney, Jennifer Logue, Stephanie Taylor
Funding Committee recommendation: Decline

NIHR128645: The FEST PUMP Trial: a randomised controlled trial of a free breast pump and support service (Professor Pat Hoddinott, University of Stirling)

Chair: Lucy Chappell
Declared a conflict and left the room: Susan Jowett, Daniel Lasserson, Edwin van Teijlingen
Funding Committee recommendation: Decline

NIHR128784: Best Endovenous treatment, including STenting, versus best non-endovenous treatment in chronic proximal deep venous disease – the BEST multi-centre randomised controlled trial (Professor Alun Davies, Imperial College London)

Chair: Julia Brown
Declared a conflict and left the room: Lucy Chappell, Sharon Simpson
Funding Committee recommendation: Decline

NIHR128351: Effect of high-flow nasal therapy on patient-centred outcomes in patients at high risk of postoperative pulmonary complications after cardiac surgery: a multicentre randomised controlled trial (Professor Andrew Klein, Papworth Hospital NHS Foundation Trust)

Chair: Julia Brown
Declared a conflict and left the room: Jennifer Logue, Lucy Chappell
Funding Committee recommendation: Shortlist

NIHR128699: Hemithyroidectomy or Total-Thyroidectomy in ‘low-risk’ thyroid cancers (HoT trial) (Professor Dae Kim, St George's University Hospitals NHS Foundation Trust)

Chair: Julia Brown
Declared a conflict and left the room: Lucy Chappell
Funding Committee recommendation: Shortlist

NIHR128146: Nurse-supported Type 2 diabetes self-management for adults with a learning disability: A pragmatic randomised controlled trial to test the clinical and cost-effectiveness of the ‘OK Diabetes’ intervention compared to usual care: the OK Diabetes Trial (Professor Suzanne Richards, University of Leeds)

Chair: Lucy Chappell
Declared a conflict and left the room: Kathryn Radford, Susan Jowett, Alan Montgomery, Daniel Lasserson, Julia Brown, Paul Ewings, Sharon Simpson
Left meeting: Charlotte Coles
Funding Committee recommendation: Decline

NIHR128311: ATNEC - Axillary management in T1-3N1M0 breast cancer patients with needle biopsy proven nodal metastases at presentation after neoadjuvant chemotherapy (Associate Professor Amit Goyal, Derby Hospitals NHS Foundation Trust)

Chair: Lucy Chappell
Declared a conflict and left the room: Rebecca Kearney, Alan Montgomery, Deborah Keatley
Funding Committee recommendation: Shortlist

NIHR128362: Referral for heart failure diagnosis - natriuretic peptide (REFER-NP) study (Dr Clare Taylor, University of Oxford)

Chair: Lucy Chappell
Declared a conflict and left the room: Rebecca Kearney, Susan Jowett, Daniel Lasserson, Thomas Pinkney
Funding Committee recommendation: Decline

NIHR128536: GRoups for Engaging efficiently with Alexander Technique (GREAT study) (Professor Paul Little, University of Southampton)

Chair: Lucy Chappell
Declared a conflict and left the room: Susan Jowett, Gail Thornton, Daniel Lasserson, David Ekers, William Hollingworth, Stephanie Taylor
Left meeting: Hywel Williams
Funding Committee recommendation: Decline

NIHR128716: Randomised controlled trial of a screen-treat-support intervention for hearing loss in people with mild dementia or cognitive impairment to delay cognitive decline. (Professor Jaydip Ray, Sheffield Teaching Hospitals NHS Foundation Trust)

Chair: Lucy Chappell
Declared a conflict and left the room: Alan Montgomery, Scott Weich
Funding Committee recommendation: Decline

NIHR128807: Pragmatic cluster randomised trial of a spirometry and FeNO based asthma management algorithm in primary care to reduce asthma attacks in children (Associate Professor Erol Gaillard, University of Leicester)

Chair: Lucy Chappell
Declared a conflict and left the room: Kathryn Radford, Alan Montgomery, Tim Coleman, William Hollingworth
Funding Committee recommendation: Decline

NIHR128762: Effects of Mediterranean-style diet supplemented with nuts and olive oil in pregnancy on wheeze, asthma and allergy disorders in offspring: Follow-up of ESTEEM randomised trial with Individual Participant Data (IPD) meta-analysis (Professor Shakila Thangaratinam, Queen Mary University of London)

Chair: Julia Brown
Declared a conflict and left the room: Jennifer Logue, Susan Jowett, Daniel Lasserson, Lucy Chappell, Sharon Simpson, Stephanie Taylor
Funding Committee recommendation: Decline

NIHR128768: Robotic Arthroplasty: a Clinical and cost Effectiveness Randomised Controlled Trial. (RACER) (Associate Professor Andrew Metcalfe, University of Warwick)

Chair: Lucy Chappell
Declared a conflict and left the room: Rebecca Kearney, Sally Hopewell, Scott Weich, Stephanie Taylor
Left meeting: Jennifer Logue
Funding Committee recommendation: Shortlist

NIHR128761: A randomised controlled trial to determine the clinical effectiveness and cost-effectiveness of DREAMS START (Dementia RElAted Manual for Sleep; STrAtegies for RelaTives) (Dr Penny Rapaport, University College London)

Chair: Julia Brown
Declared a conflict and left the room: Kathryn Radford, Athanasios Saratzis, Alan Montgomery, Lucy Chappell, Sharon Simpson
Funding Committee recommendation: Shortlist

NIHR128811: A national randomised controlled trial to compare in situ normothermic regional perfusion with ex vivo normothermic machine perfusion in human liver transplantation from donation after circulatory death donors (Mr Vasilis Kosmoliaptsis, University of Cambridge)

Chair: Lucy Chappell
Declared a conflict and left the room: None
Funding Committee recommendation: Decline

NIHR128815: A multicentre, randomised controlled trial of Laparoscopic versus Open Colorectal Surgery in the Acute Setting (Ms Deena Harji, The Newcastle Upon Tyne Hospitals NHS Foundation Trust)

Chair: Lucy Chappell
Declared a conflict and left the room: Julia Brown
Funding Committee recommendation: Shortlist

NIHR128894: iHOPE UK study: Improve Hip Fracture Outcome in the Elderly Patient UK - UK arm of an international multicentre randomized controlled trial to test the efficacy of spinal versus general anaesthesia (Associate Professor Joyce Yeung, University Hospitals Birmingham NHS Foundation Trust)

Chair: Lucy Chappell
Declared a conflict and left the room: Rebecca Kearney, Thomas Pinkney, Alan Montgomery, Daniel Lasserson, Scott Weich
Funding Committee recommendation: Decline 

NIHR128208: Safe Antimicrobial ProPHylaxIs suRgEry trial (SAPPHIRE) (Professor Rupert Pearse, Queen Mary University of London)

Chair: Julia Brown
Declared a conflict and left the room: Rebecca Kearney, Alan Montgomery, Sharon Simpson, Stephanie Taylor
Funding Committee recommendation: Resubmission

NIHR128885: Retrospective cohort study of prescription of medication for mental health conditions in epilepsy and seizure frequency, health care resource utilisation and mortality: innovative and cost-efficient use of routinely collected data with health economics assessment. (Associate Professor Richard Chin, The University of Edinburgh)

Chair: Lucy Chappell
Declared a conflict and left the room: None
Funding Committee recommendation: Decline