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HTA Funding Committee Public Minutes 12-13 November 2019

Contents

Date

Tuesday 12th November 2019 (Day 1)

Place

Danubius, London

Present members

Professor Andrew Farmer (Chair)
Professor John Norrie (Deputy Chair)
Professor Hywel Williams (Programme Director)
Miss Kirstin Carswell
Professor Fay Crawford
Dr Jo Dumville
Professor Nick Francis
Professor Caroline Free
Professor Simon Gates
Professor Colin Green
Professor Kerenza Hood
Professor Nick James
Professor Asma Khalil
Professor Steff Lewis
Dr Rumana Omar
Professor Rupert Pearse
Professor Mark Peters
Professor Craig Ramsay
Mrs Amanda Roberts (PPI)
Professor Christine Roffe
Associate Professor Jo Thompson-Coon
Dr Marc Serfaty
Dr Sarah Stock
Dr Sara Twaddle
Professor Olivia Wu

NETSCC, HTA Secretariat

Dr Simon Fraser (Consultant Advisor)

Helen Payne (Senior Research Manager)

Miss Louise Maclachlan (Research Manager)
Miss Louisa Saunders (Assistant Research Manager)

Apologies

Professor Julie Brittenden
Mr Alan Chant
Professor Matt Costa
Professor Julia Lawton

Observers

Dr Jason Horsley (NETSCC Consultant Advisor).
Alexandra Griffiths (Monitoring Assistant Research Manager)
Lesley Dodd (Monitoring Senior Research Manager)

Quoracy Information

Voting members: 28 Quorum = 19
Voting members present on Day 1: 24 (86%)

 

18/145: HTA Pain Themed Call (Evidence Synthesis) Stage 2 application

 

NIHR128842: Safe and effective gradual reduction (tapering) of opioids in people with chronic non-cancer pain: systematic review of effects, barriers and facilitators and inequalities to inform service design in the NHS

(Dr Ruaraidh Hill, University of Liverpool)

Chair: Andrew Farmer
Declared a conflict and left the room: Jo Dumville
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

 

HTA Researcher-Led Stage 2 Applications

 

NIHR129708: Safety and effectiveness of tranexamic acid (TXA) in trauma and surgery in the NHS: A systematic review and individual patient data (IPD) meta-analysis.

(Dr Katharine Ker, London School of Hygiene & Tropical Medicine)

Chair: Andrew Farmer
Declared a conflict and left the room: Asma Khalil, Caroline Free
Funding Committee recommendation: Decline

 

NIHR129715: Diet and physical activity in pregnancy to prevent gestational diabetes: Individual Participant Data (IPD) meta-analysis on the differential effects of interventions with economic evaluation

(Professor Shakila Thangaratinam, Queen Mary University of London)

Chair: Andrew Farmer
Declared a conflict and left the room: Fay Crawford, Sarah Stock, Asma Khalil, Olivia Wu, John Norrie
Funding Committee recommendation: Programme Oversight Committee to consider straight fund

 

NIHR129713: Effectiveness and cost-effectiveness of gynaecological surveillance for women with Lynch syndrome: systematic reviews and economic evaluation

(Dr Tristan Snowsill, University of Exeter)

Chair: Andrew Farmer
Declared a conflict and left the room: Jo Dumville, Colin Green, Joanna Thompson-Coon, Simon Gates
Funding Committee recommendation: Programme Oversight Committee to consider straight fund

 

NIHR129523: BEhavioural Weight Management: COMponents of Effectiveness (BE:COME)

(Dr Jennifer Logue, Lancaster University)

Chair: Andrew Farmer
Declared a conflict and left the room: Craig Ramsay, Olivia Wu:
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

 

19/18: HTA Digital Technologies to Improve Health and Care

 

NIHR129248: Digital technologies for home monitoring glaucoma: a feasibility study.

(Dr Katie Gillies, University of Aberdeen)

Chair: Andrew Farmer
Declared a conflict and left the room: Craig Ramsay, John Norrie, Kerenza Hood, Amanda Roberts
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

 

Commissioned Stage 2 Applications

 

19/28: Endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused by unresectable cancer

NIHR129784: Endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused by unresectable cancer - evidence synthesis.

(Dr John Leeds, The Newcastle Upon Tyne Hospitals NHS Foundation Trust)

Chair: Andrew Farmer
Declared a conflict and left the room: Craig Ramsay
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

 

Cross-Programme Commissioning Stage 1 Applications

 

19/18: HTA Digital Technologies to Improve Health and Care

NIHR129334: The clinical and cost effectiveness of home-based active video gaming therapy vs. treatment as usual on motor function of children with cerebral palsy: a pragmatic multi-centre randomised controlled trial with parallel process evaluation

(Dr William Farr, Sussex Community NHS Trust)

Chair: Andrew Farmer
Declared a conflict and left the room: Colin Green, Joanna Thompson-Coon
Funding Committee recommendation: Decline

 

Commissioned Stage 1 Applications

19/73: The use of mucoactive agents for patients with acute respiratory failure in critical care

NIHR130454: Mucoactive drugs for acute respiratory failure: A 2x2 factorial, randomised, controlled, allocation concealed, open-label, Phase 3, pragmatic, clinical and cost effectiveness trial with internal pilot 

(Dr Bronwen Connolly, The Queen's University of Belfast)

Chair: Andrew Farmer
Declared a conflict and left the room: Hywel Williams, Mark Peters, Simon Gates
Funding Committee recommendation: Shortlist

 

19/74: Neurostimulation for phantom limb pain

NIHR130711: Study of Phantom limb paIn and dorsal Root ganglIon sTimulation: the UK SPIRIT Trial

(Professor Julie Bruce, University of Warwick)

Chair: Andrew Farmer
Declared a conflict and left the room: Jo Dumville, Olivia Wu, Simon Gates, Marc Serfaty, Colin Green, Simon Fraser
Funding Committee recommendation: Shortlist

 

NIHR130456: The Efficacy of Combined Dorsal Root Ganglion and Spinal Cord Stimulation in the Management of Severe Phantom Limb Pain: A Multicentre, Randomised Double-Blind Placebo-Controlled Study (PHANTOM)

(Dr Adnan Al-Kaisy, Guy's and St Thomas' NHS Foundation Trust)

Funding Committee recommendation: Shortlist

Commissioned Evidence Synthesis Stage 1 Applications

 

19/29: Frequency of blood tests for inflammatory conditions

Chair: Sara Twaddle
Declared a conflict and left the room: Fay Crawford, Sarah Stock, Joanna Thompson-Coon, John Norrie, Kerenza Hood, Nick Francis, Olivia Wu, Hywel Williams, Andrew Farmer, Amanda Roberts, Christine Roffe, Marc Serfaty, Simon Fraser

NIHR129954: Personalised and Effective blood Test monitoring in Inflammatory Conditions (PoETIC)

(Professor Anthony Fryer, University Hospitals of North Midlands NHS Trust)

Funding Committee recommendation: Decline

NIHR129778: Strategies for blood test monitoring in patients taking common immunosuppressive drugs in primary care

(Dr Sarah Lay-Flurrie, University of Oxford)

Funding Committee recommendation: Shortlist

NIHR130580: The development of risk-stratified, cost-effective, and acceptable blood-test monitoring strategies for people with inflammatory conditions treated with frequently used immune suppressing drugs: a multi-method study using evidence synthesis, modelling and qualitative research.  

(Dr A Abhishek, University of Nottingham)

Funding Committee recommendation: Shortlist

NIHR130714: Optimisation of the frequency of blood testing for routine DMARD surveillance in common inflammatory diseases using an inter-regional, data-driven approach 

(Dr Fraser Cummings, University Hospital Southampton NHS Foundation Trust)

Funding Committee recommendation: Shortlist

NIHR130668: Optimal strategies to monitor for Adverse drug reactions to Disease-Modifying anti-Rheumatic drugs (ADMIRE)

(Dr Ruth Lewis, Bangor University)

Funding Committee recommendation: Decline

NIHR130634: Frequency of blood tests for inflammatory conditions

(Professor Neil Hawkins, University of Glasgow)

Funding Committee recommendation: Decline

 

Broad Brief – 19/30: Strategies in older people’s care settings to prevent infection

 

NIHR130396: ‘StOP UTI’ - STrategies in Older People’s care to prevent Urinary Tract Infection: a realist synthesis of the evidence

(Associate Professor Jacqui Prieto, University of Southampton)

Chair: Andrew Farmer
Declared a conflict and left the room: none
Funding Committee recommendation: Shortlist

 

Date

Wednesday 13th November 2019 (Day 2)

Place

Danubius, London

Present members

Professor Andrew Farmer (Chair)
Professor John Norrie (Deputy Chair)
Professor Hywel Williams (Programme Director)
Miss Kirstin Carswell
Professor Matt Costa
Professor Fay Crawford
Dr Jo Dumville
Professor Nick Francis
Professor Caroline Free
Professor Simon Gates
Professor Colin Green
Professor Kerenza Hood
Professor Nick James
Professor Steff Lewis
Dr Rumana Omar
Professor Rupert Pearse
Professor Mark Peters
Professor Craig Ramsay
Mrs Amanda Roberts (PPI)
Professor Christine Roffe
Associate Professor Jo Thompson-Coon
Dr Sarah Stock
Dr Sara Twaddle
Professor Olivia Wu

NETSCC, HTA Secretariat

Dr Simon Fraser (Consultant Advisor)
Steph Garfield-Birkbeck (Head of the HTA Programme)
Helen Payne (Senior Research Manager)
Miss Louise Maclachlan (Research Manager)
Miss Louisa Saunders (Assistant Research Manager)

Apologies

Professor Julie Brittenden
Mr Alan Chant,
Professor Asma Khalil
Dr Marc Serfaty
Professor Julia Lawton

Observers

Dr Jason Horsley (NETSCC Consultant Advisor).

Quoracy Information

Voting members: 28 Quorum = 19
Voting members present on Day 2: 23 (82%)

 

Day 2

 

HTA Data Enabled Trials Call Stage 1 Applications

19/109: HTA Call for ambitious data-enabled trials, health services and public health research studies

NIHR130280: Preventing stroke, premature death and cognitive decline in a broader community of patients with atrial fibrillation using healthcare data for pragmatic research

(Dr Dipak Kotecha, University of Birmingham)

Chair: John Norrie
Declared a conflict and left the room: Andrew Farmer, Nick James
Arrived meeting: Matt Costa
Committee recommendation: Shortlist

 

NIHR130145: Randomised trial of Thyroid hormone replacement for Subclinical HypOthyroidism: effects on Quality of life and cardiovascular outcomes (ThySHOQ) 

(Dr Peter Taylor, Cardiff University)

Chair: Andrew Farmer
Declared a conflict and left the room: Kerenza Hood
Committee recommendation: Decline

 

NIHR130548: SYmptom-driven versus Maintenance Preventer Therapy for the Outpatient Management of AsThma In Children (SYMPTOMATIC)

(Dr Ian Sinha, Alder Hey Children's NHS Foundation Trust)

Chair: Hywel Williams
Declared a conflict and left the room: Sarah Stock, Andrew Farmer, John Norrie, Kerenza Hood, Steff Lewis
Committee recommendation: Shortlist

 

NIHR130553: Tonsillectomy Observational National Study Investigating real-Life data from Secondary care (TONSILS)

(Mr Steven Powell, Newcastle upon Tyne Hospitals NHS Foundation Trust)

Chair: Andrew Farmer
Declared a conflict and left the room: none
Committee recommendation: Decline

 

NIHR130508: Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care (UK ROX) 

(Dr Daniel Martin, University College London)

Chair: Andrew Farmer
Declared a conflict and left the room: Mark Peters, Rumana Omar
Committee recommendation: Shortlist

 

NIHR130565: DIRECT Study: a highly pragmatic, efficient, whole population randomised trial of thromboprophylaxis in hip fracture.

(Associate Professor Xavier Griffin, University of Oxford)

Chair: John Norrie
Declared a conflict and left the room: Andrew Farmer, Craig Ramsay, Matt Costa
Left the meeting: Hywel Williams
Committee recommendation: Resubmission

 

NIHR130573: VolatIle vs Total intravenous Anaesthesia for major non-cardiac surgery – a randomised controlled triaL (VITAL)

(Associate Professor Joyce Yeung, University of Warwick)

Chair: Andrew Farmer
Declared a conflict and left the room: John Norrie, Rupert Pearse, Simon Gates
Committee recommendation: Shortlist

 

Researcher-Led Stage 1 Applications

NIHR130464: Cow's milk protein allergy: evaluating the accuracy, effectiveness and cost-effectiveness of tests and strategies to aid the diagnostic process 

(Dr Jaime Peters, University of Exeter)

Chair: Andrew Farmer
Declared a conflict and left the room: Colin Green, Joanna Thompson-Coon
Committee recommendation: Decline

 

NIHR129972: Randomised trial of clinical and cost effectiveness of Administration of Prehospital fascia Iliaca compartment block for emergency Pre-Hospital hip fracture care Delivery (RAPID 2)

(Professor Helen Snooks, Swansea University)

Chair: Andrew Farmer
Declared a conflict and left the room: Joanna Thompson-Coon, Kerenza Hood, Nick Francis
Committee recommendation: Shortlist

 

NIHR130509: EVIDENCE EValuatIng DiurEtics in Normal CarE: - a cluster randomised study of prescribing policy for thiazide-type drugs used for primary hypertension 

(Dr Alexander Doney, University of Dundee)

Chair: Andrew Farmer
Declared a conflict and left the room: none
Committee recommendation: Decline

 

NIHR130437: Mixed method systematic review to identify the most effective and helpful components of early intervention programmes aimed at promoting parent-child interaction from conception to 5 years 

(Professor Jane Barlow, University of Oxford)

Chair: John Norrie
Declared a conflict and left the room: Andrew Farmer, Colin Green, Joanna Thompson-Coon
Committee recommendation: Decline

 

NIHR130445: UK Asymptomatic Mitral Regurgitation Study (UK-AdMiRe)

(Associate Professor Saul Myerson, Oxford University Hospitals NHS Foundation Trust)

Chair: John Norrie
Declared a conflict and left the room: Andrew Farmer
Committee recommendation: Decline

 

NIHR129820: What is the clinical-effectiveness and cost-effectiveness of surgery with medial opening wedge high tibial osteotomy (HTO) compared with non-surgical treatment in the management of osteoarthritis (OA) of the knee in patients younger than 60 years? (MOTION Trial)

(Mr Anish Amin, Edinburgh Royal Infirmary)

Chair: Andrew Farmer
Declared a conflict and left the room: Sarah Stock, John Norrie, Simon Gates, Steff Lewis
Committee recommendation: Shortlist

 

NIHR129926: Best systemic treatments for adults with atopic eczema over the long term (BEACON): A randomised, double blind trial comparing ciclosporin, methotrexate and dupilumab 

(Professor Catherine Smith, Guy's and St Thomas' NHS Foundation Trust)

Chair: Andrew Farmer
Declared a conflict and left the room: John Norrie, Rumana Omar, Amanda Roberts
Left meeting: Nick James
Committee recommendation: Shortlist

 

NIHR130593: Controlled trial of High-risk percutaneous coronary Intervention with Percutaneous left ventricular unloading (CHIP)

(Professor Divaka Perera, King's College London)

Chair: Andrew Farmer
Declared a conflict and left the room: Mark Peters, Rumana Omar, Caroline Free
Committee recommendation: Shortlist



NIHR130632: ERASER TRIAL: Early Rib Analgesia with Serratus.A Pragmatic Randomised Control Trial evaluating the clinical and cost-effectiveness of Serratus Anterior Plane Block with catheter insertion compared to Usual Care in patients with multiple rib fractures. 

(Dr Tonny Veenith, University Hospitals Birmingham NHS Foundation Trust)

Chair: Andrew Farmer
Declared a conflict and left the room: Simon Gates, Nick James, Christine Roffe
Committee recommendation: Shortlist

Close of day 2