This site is optimised for modern browsers. For the best experience, please use Google Chrome, Mozilla Firefox, or Microsoft Edge.

Feedback

We welcome your feedback, which will help improve this site.

Feedback form

HTA Funding Committee Public Minutes 21-22 January 2020

 

Contents


NIHR HTA Funding Committee (Commissioning)

Minutes of the January 2020 Meeting

Date Tuesday 21st January 2020 (Day 1)
Place Danubius Hotel, Regent’s Park, London

Present members

Professor Joy Adamson
Dr Ben Ainsworth
Mr Paul Charlton
Professor Saul Faust
Dr Emilio Fernandez-Egea
Professor Simon Gilbody
Professor Steve Goodacre
Professor Richard Grieve
Dr Rebecca Harmston
Professor Angela Hassiotis
Mr Rakesh Heer
Professor Catherine Hewitt
Professor Pip Logan
Professor Nick Maskell
Professor Jane Nixon
Mr Daniel Perry
Dr Greta Rait
Professor Rebecca Reynolds
Professor Chris Rogers
Professor Jonathan Ross
Professor Andrew Shennan
Professor Sobha Sivaprasad
Dr Chris Sutton
Professor Catrin Tudur-Smith
Dr Katrina Turner
Professor Hywel Williams
Professor Nefyn Williams

NETSCC, HTA Secretariat

Dr Nick Hicks (Consultant Advisor)
Ms Kathy Tier (Research Manager)
Mrs Karen Williams (Senior Research Manager)
Miss Alessandra Wilkinson-Smith (Assistant Research Manager)

Observers

Julie McCarroll, HSC R&D Division (Day 2 only)

Apologies

Professor Gary Collins
Professor Tracey Sach
Mr Rakesh Heer (Day 2 only)
Professor Catrin Tudur-Smith (Day 2 only)

Day 1

Commissioning Stage 2 Proposals, shortlisted at September 2019 Committee

18/43: Rotation of the fetal head at full cervical dilatation

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Associate Professor Daniel Perry, Dr Christopher Sutton, Mr Rakesh Heer, Professor Andrew Shennan, Professor Hywel Williams, Professor Rebecca Reynolds

NIHR127818: ROTATE Rotation of the fetal head at full cervical dilatation (Associate Professor Dimitrios Siassakos, UCL Institute for Women’s Health)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR127266: ManuAl verSuS InStrumental roTation: ASSIST trial (Professor Fiona Denison, The University of Edinburgh)
Funding Committee recommendation: Decline

18/186: Active management vs conservative management for symptomatic brain cavernoma

Chair: Professor Simon Gilbody
Declared a conflict and left the room: Dr Emilio Fernandez-Egea, Dr Katrina Turner, Mr Rakesh Heer, Professor Catrin Tudur Smith, Professor Chris Rogers, Professor Rebecca Reynolds, Professor Steve Goodacre

NIHR128694: Cavernomas A Randomised Effectiveness (CARE) pilot trial, to address the effectiveness of active treatment (with neurosurgery or stereotactic radiosurgery) versus conservative management in people with symptomatic brain cavernoma (Professor Rustam Salman, The University of Edinburgh)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/31: Gastrointestinal side effects in cancer immune checkpoint therapy

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Dr Ben Ainsworth, Professor Hywel Williams, Professor Saul Faust

NIHR129948: ARTISTIX: A randomised trial of intravenous steroid therapy +/- infliximab for gastrointestinal side effects in cancer immune checkpoint therapy (Dr Matthew Wheater, University Hospital Southampton NHS Foundation Trust)
Funding Committee recommendation: Decline Return to POC

19/32: Behavioural intervention to treat anxiety in adults with autism and moderate to severe learning disabilities

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Angela Hassiotis, Professor Chris Rogers

NIHR129804: Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities (BEAMS – ID) (Professor Peter Langdon, University of Warwick)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/33: Treating specific phobias in children with moderate to severe learning disabilities

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Angela Hassiotis, Professor Hywel Williams, Professor Simon Gilbody

NIHR130308: Treating specific phobias in children with moderate to severe learning disabilities (Professor Barry Wright, University of York)
Funding Committee recommendation: Decline

NIHR130177: Specific phobias in children with learning disabilities (SPIRIT): An adaptation and feasibility study (Professor Kylie Gray, University of Warwick)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/34: Medication for ADHD in adults with a history of psychosis or bipolar disorder

Chair: Professor Simon Gilbody
Declared a conflict and left the room: Professor Jonathan Ross
Professor Joy Adamson joined the meeting

NIHR129817: The clinical and cost-effectiveness of Stimulant compared with Non-stimulant medication for adults with Attention-deficit / hyperactivity disorder and a history of Psychosis or biPolar disordER: SNAPPER (Professor Steven Marwaha, University of Birmingham)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/37: Deep infiltrating endometriosis

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Dr Christopher Sutton, Dr Katrina Turner, Mr Rakesh Heer, Professor Chris Rogers, Professor Hywel Williams, Professor Philippa Logan, Professor Rebecca Reynolds

NIHR130310: Deep infiltrating endometriosis: management by medical treatment versus early surgery: DIAMOND (Professor Kevin Cooper, NHS Grampian)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/38: Scanning confocal ophthalmoscopy for diabetic eye screening

Chair: Professor Simon Gilbody
Declared a conflict and left the room: Professor Catrin Tudur Smith, Professor Sobha Sivaprasad

NIHR129647: Scanning confocal ophthalmoscopy for diabetic eye screening (Professor Peter Scanlon, Gloucestershire Hospitals NHS Foundation Trust)
Funding Committee recommendation: Decline Return to POC

19/39: Minimally invasive operative interventions for bladder outlet obstruction due to benign prostatic hyperplasia

Chair: Professor Simon Gilbody
Declared a conflict and left the room: Dr Christopher Sutton, Dr Katrina Turner, Mr Rakesh Heer, Professor Chris Rogers, Professor Steve Goodacre
Saul Faust left the meeting

NIHR129747: A randomised trial of minimally invasive treatments for bladder outlet obstruction due to enlarged prostate in the National Health Service using a network of treating centres.
Acronym: OPTIONS Trial. Options for Prostate Treatment Innovation Or Normal Surgery (Dr Tobias Page, The Newcastle Upon Tyne Hospitals NHS Foundation Trust)
Funding Committee recommendation: Decline Return to POC

19/40: Needle and syringe exchange schemes and opiate substitution therapy in the UK

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Dr Katrina Turner, Professor Chris Rogers, Professor Greta Rait

NIHR129798: Title: Understanding the contextual factors that impact on the effective provision of opiate substitution therapy (OST) and needle and syringe programmes (NSP) in the UK: a multi-method study and realist evaluation of what works, for whom and under what c (Dr Alison Munro, University of Dundee)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR130004: ENGAGE - A realist informed evaluation of the combined effectiveness of needle and syringe provision and opioid substitution therapy programmes for people who inject drugs (Professor Vivian Hope, Liverpool John Moores University)
Funding Committee recommendation: Decline

Stage 1 applications from call close December 2019

19/151: HTA Solid Organ Replacement, Transplant And Donation

Chair: Professor Steve Goodacre
No conflicts

NIHR131124: Statins in Organ Donor Management. An evaluation of the benefits of giving a single dose of Simvastatin to brain-stem dead organ donors on outcomes in recipients of organs from the donor
SIGNET Statins for Improving orGan outcomE in Transplantation (Professor John Dark, University of Newcastle upon Tyne)
Funding Committee recommendation: Shortlist

19/151: HTA Solid Organ Replacement, Transplant And Donation

Chair: Professor Steve Goodacre
No conflicts

NIHR130656: A randomized controlled trial assessing the safety and efficacy of robotic assisted versus open living donor kidney transplantation (Professor Nizam Mamode, Guy's and St Thomas' NHS Foundation Trust)
Funding Committee recommendation: Decline

NIHR131058: A prospective randomized controlled trial of robotic assisted versus laparoscopic assisted living donor nephrectomy. (Mr Ioannis Loukopoulos, Guy's and St Thomas' NHS Foundation Trust)
Funding Committee recommendation: Decline

19/151: HTA Solid Organ Replacement, Transplant And Donation

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Rakesh Heer, Jane Nixon

NIHR130679: A randomised controlled trial of Intra-operative Mannitol for the Prevention of delayed grAft function in deceased donor Renal Transplant (IMPART) (Mr Adam Barlow, Leeds Teaching Hospitals NHS Trust)
Funding Committee recommendation: Decline

19/41: Clozapine for children and young people with treatment resistant schizophrenia

Chair: Professor Steve Goodacre
DCMs: 1. Professor Joy Adamson, 2. Professor Philippa Logan, 3. Professor Gary Collins(w)
Declared a conflict and left the room: Dr Christopher Sutton, Dr Emilio Fernandez-Egea, Professor Angela Hassiotis, Professor Catrin Tudur Smith, Professor Greta Rait

NIHR131175: CLEAR: (CLozapine in EARly psychosis) A Multi-Centre, Randomised Controlled trial of Clozapine for Young People with Treatment Resistant Psychosis in Real World Settings (Professor James MacCabe, Kings College London)
Funding Committee recommendation: Shortlist

19/42: Selective serotonin reuptake inhibitor to prevent depression following traumatic brain injury

Chair: Professor Simon Gilbody
Declared a conflict and left the room: Dr Christopher Sutton, Dr Emilio Fernandez-Egea, Professor Catrin Tudur Smith, Professor Jonathan Ross, Professor Rebecca Reynolds, Professor Steve Goodacre


NIHR130879: RandomIsed COnTrol Trial Anti depressants in Traumatic Brain Injury, RICOTTA-TBI (Mr Adel Helmy, University of Cambridge)
Funding Committee recommendation: Shortlist


NIHR131170: ENDBIT - ENding Depression in Brain Injury Trial. A placebo randomised controlled trial of fluoxetine to prevent depression in traumatic brain injury. (Professor Diane Playford, University of Warwick)
Funding Committee recommendation: Decline


NIHR131125: A multi-centre randomised controlled trial of the clinical and cost-effectiveness of sertraline in preventing depression in adults following a traumatic brain injury (Professor Khalida Ismail, King's College London)
Funding Committee recommendation: Shortlist

19/43: Amitriptyline for the prevention of post-herpetic neuralgia

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Dr Ben Ainsworth, Dr Katrina Turner, Professor Chris Rogers, Professor Jane Nixon

NIHR131035: Prevention of Shingles Pain Trial (PROSPECT) (Professor Julie Bruce, University of Warwick)
Funding Committee recommendation: Shortlist

NIHR129720: ATHENA: AmiTritypline for the prevention of post-HErpetic NeuralgiA (Dr Matthew Ridd, University of Bristol)
Funding Committee recommendation: Shortlist

19/44: Nutrient enriched diet for babies with a brain injury

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Mr Rakesh Heer, Professor Andrew Shennan, Dr Christopher Sutton

NIHR129699: 19/44 Nutrient enriched diet for babies with a brain injury (Dr Suresh Victor, King's College London)
Funding Committee recommendation: Decline

NIHR130925: Investigating the clinical and cost-effectiveness of a nutrient enriched diet for babies with a brain injury: The Dolphin Randomised controlled trial (Professor Jeremy Parr, University of Newcastle upon Tyne)
Funding Committee recommendation: Shortlist

 

Day 2

Commissioning Stage 1 proposals – received from December 2019 call close

19/76: Antipsychotics for anorexia nervosa

Chair: Professor Simon Gilbody
No conflicts

NIHR130780: Olanzapine for young PEople with aNorexia nervosa: An open-label feasibility study to test recruitment, treatment acceptance, adherence, safety, outcome measures and patients' experience to prepare for a randomised placebo-controlled trial (OPEN) (Dr Hubertus Himmerich, King's College London)
Funding Committee recommendation: Shortlist

19/75: Stem cell transplant for adults with severe sickle cell disease

Chair: Professor Simon Gilbody
Declared a conflict and left the room: Professor Andrew Shennan, Professor Hywel Williams, Professor Steve Goodacre, Associate Professor Daniel Perry

NIHR130674: Randomised trial of Haploidentical Transplantation compared to standard of care for Adults with Sickle Cell Disease (Dr Victoria Potter, King's College Hospital NHS Foundation Trust)
Funding Committee recommendation: Shortlist

19/88: Ablative and non-invasive therapies for hepatocellular carcinoma

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Greta Rait, Professor Jonathan Ross, Professor Rebecca Reynolds, Professor Simon Gilbody

NIHR131224: Ablative and non-invasive therapies for hepatocellular carcinoma (Professor Alison Eastwood, University of York)
Funding Committee recommendation: Shortlist

NIHR131201: Ablative and non-invasive therapies for hepatocellular carcinoma (Dr David Moore, University of Birmingham)
Funding Committee recommendation: Decline

NIHR131177: Ablative and non-ablative therapies in the management of early stage hepatocellular cancer: comprehensive meta-analysis and systematic review (Dr Rohini Sharma, Imperial College London)
Funding Committee recommendation: Decline

NIHR131150: Systematic review and network meta-analysis of ablative and non-invasive therapies for hepatocellular carcinoma under 3 centimetres. (Dr Thomas Drake, The University of Edinburgh)
Funding Committee recommendation: Decline

NIHR130791: Ablative and non-invasive therapies for small hepatocellular carcinoma: a systematic review and network meta-analysis (Professor Kurinchi Gurusamy, University College London)
Funding Committee recommendation: Decline

19/77: Monitoring and follow-up for adults with hearing loss

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Dr Christopher Sutton, Professor Hywel Williams, Professor Jonathan Ross, Professor Philippa Logan

NIHR131159: Follow-up and structured monitoring for adults offered a NHS hearing aid for the first time (FAMOUS): a cluster randomised controlled trial (Professor Kevin MUNRO, The University of Manchester)
Funding Committee recommendation: Shortlist

NIHR130644: Clinical efficacy and cost-effectiveness of treatment and follow-up regimens for management of mild-to-moderate hearing loss in adults. (Professor Manohar Bance, Cambridge University Hospitals NHS Foundation Trust)
Funding Committee recommendation: Decline

NIHR131166: Does e-follow-up improve outcomes for adults with hearing loss compared with existing practice? (Mr Adam Beckman, University Hospitals Plymouth NHS Trust)
Funding Committee recommendation: Decline

19/78: Ambulatory oxygen therapy in idiopathic pulmonary fibrosis

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Jonathan Ross

NIHR130294: A phase III parallel group randomized controlled multi-centre trial to evaluate effects of ambulatory oxygen on quality of life and its cost-effectiveness in patients with idiopathic pulmonary fibrosis and isolated exertional hypoxia. (Dr Elisabetta Renzoni, Royal Brompton & Harefield NHS Foundation Trust)
Funding Committee recommendation: Shortlist

NIHR131149: Ambulatory oxygen for pulmonary fibrosis (OxyPuF) (Dr Alice Turner, University of Birmingham)
Funding Committee recommendation: Shortlist

19/79: Idiopathic intracranial hypertension

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Associate Professor Daniel Perry, Mr Rakesh Heer, Professor Hywel Williams, Professor Jonathan Ross, Professor Nefyn Williams

NIHR131211: The Resolution by Intervention in IIH Trial: clinical effectiveness and cost effectiveness (RIIHT Trial) (Professor Alexandra Sinclair, University of Birmingham)
Funding Committee recommendation: Shortlist

NIHR130823: Randomised Evaluation of Venous Intervention versus Shunting in IIH with Optic Nerve disc swelling (REVISION) (Miss Catherine McMahon, The Walton Centre NHS Foundation Trust)
Funding Committee recommendation: Shortlist

19/80: Posterior decompressive surgery with fixation for degenerative cervical myelopathy

Chair: Professor Steve Goodacre
No conflicts

NIHR130825: Title: Decompression and fusion versus decompression alone in degenerative cervical myelopathy, a randomised controlled trial (DAFVED trial) (Mr Jasmeet Dhir, University Hospitals Birmingham NHS Foundation Trust)
Funding Committee recommendation: Decline

NIHR131243: FUSION4DCM? Posterior decompressive surgery with fixation for degenerative cervical myelopathy (Dr Mark Kotter, University of Cambridge)
Funding Committee recommendation: Shortlist

19/81: Neoadjuvant endocrine therapy for postmenopausal women with breast cancer

Chair: Professor Simon Gilbody
Declared a conflict and left the room: Associate Professor Daniel Perry, Dr Katrina Turner, Professor Chris Rogers, Professor Saul Faust

NIHR131046: Randomised controlled trial evaluating effectiveness of neoadjuvant endocrine treatment in post-menopausal women (EndoNET) (Professor Michael Douek, University of Oxford, Nuffield Department of Surgical Sciences)
Funding Committee recommendation: Shortlist

NIHR130895: NEO-LEAP: Defining patient centred benefit of neoadjuvant letrozole alone versus letrozole plus palbociclib in genomically defined ER-positive, HER2-Negative Primary Breast Cancer
(Professor Carlo Palmieri, University of Liverpool)
Funding Committee recommendation: Decline

19/82: Conservative management of odontoid fracture in the elderly: to immobilise or not?

Chair: Professor Simon Gilbody
Declared a conflict and left the room: Associate Professor Daniel Perry, Professor Catherine Hewitt, Professor Chris Rogers, Professor Hywel Williams, Professor Jonathan Ross, Professor Joy Adamson, Professor Rebecca Reynolds, Professor Steve Goodacre

NIHR131213: Cervical Orthoses in the Management of FragilitY Fractures of the Odontoid Process (COMFY) (Mr James Tomlinson, Sheffield Teaching Hospitals NHS Foundation Trust)
Funding Committee recommendation: Decline

NIHR130880: Management of C2 Odontoid Vertebral Fractures (MOVe) Trial (Mr Peter Wall, University of Warwick)
Funding Committee recommendation: Decline

NIHR131230: Conservative management of odontoid fractures in the elderly. To immobilise or not? (Professor Antonio Belli, University of Birmingham)
Funding Committee recommendation: Shortlist

NIHR131118: DENS Study: Duration of External Neck Stabilisation following odontoid fracture in older or frail adults: a randomised controlled trial of collar versus no collar (Mr Paul Brennan, The University of Edinburgh)
Funding Committee recommendation: Shortlist

19/84: Surgical treatment for severe stable slipped capital femoral epiphysis (SCFE) in children

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Associate Professor Daniel Perry, Dr Katrina Turner, Professor Nefyn Williams

NIHR131176: The British Orthopaedic SCFE Surgery Study for Severe Stable Slips (The Big BOSS Study): A multi-centre prospective randomised superiority trial of an acute deformity correction versus pinning in-situ for severe stable SCFE in children. (Associate Professor Daniel Perry, University of Liverpool)
Funding Committee recommendation: Shortlist

19/85: Anti-reflux medication to reduce stricture formation following oesophageal atresia repair

Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Nefyn Williams, Professor Saul Faust

NIHR131136: Anti-reflux medication to reduce stricture formation in oesophageal atresia (Associate Professor Nigel Hall, University of Southampton)
Funding Committee recommendation: Shortlist

19/86: Thromboprophylaxis in pregnancy and after delivery

Chair: Professor Simon Gilbody
Declared a conflict and left the room: Dr Katrina Turner, Professor Andrew Shennan, Professor Chris Rogers, Professor Hywel Williams, Professor Philippa Logan, Professor Rebecca Reynolds, Professor Steve Goodacre

NIHR131021: Thromboprophylaxis in pregnancy and after delivery (Ms Sarah Davis, The University of Sheffield)
Funding Committee recommendation: Shortlist

NIHR130849: Thromboprophylaxis in pregnancy and after delivery (Professor Siobhan Quenby, University of Warwick)
Funding Committee recommendation: Decline

NIHR131131: The expected return on investment from a study of risk assessment for, and prevention of, venous thromboembolism during and immediately after pregnancy: a systematic review, economic evaluation and value of information analysis. (Dr Edward Wilson, University of East Anglia)
Funding Committee recommendation: Shortlist

19/87: Night-time only bracing for scoliosis

Chair: Professor Simon Gilbody
Declared a conflict and left the room: Associate Professor Daniel Perry, Dr Katrina Turner, Professor Catherine Hewitt, Professor Joy Adamson, Professor Nefyn Williams, Professor Steve Goodacre
Julie McCaroll left the meeting

NIHR131081: Night-time Only Bracing in Adolescent Idiopathic Scoliosis Trial (NOBAIST) (Mr Ashley Cole, Sheffield Children's NHS Foundation Trust)
Funding Committee recommendation: Shortlist

NIHR130574: Is night-time bracing equivalent to full-time bracing for the management of adolescent idiopathic scoliosis? (Mr Adrian Gardner, The Royal Orthopaedic Hospital NHS Foundation Trust)
Funding Committee recommendation: Decline

NIHR130884: The effects of night-time only bracing compared to day and night-time bracing for prevention of curve progression, and avoidance of surgery, in young people with adolescent idiopathic scoliosis: a non-inferiority randomised controlled trial (Associate Professor Sally Hopewell, University of Oxford)
Funding Committee recommendation: Decline