This site is optimised for modern browsers. For the best experience, please use Google Chrome, Mozilla Firefox, or Microsoft Edge.

Beta

We welcome your feedback, which will help improve this site.

Feedback form

HTA Remit and Competitiveness teleconference - Public minutes June 2019

 

Contents

 

 

NIHR HTA Remit and Competitiveness Teleconference

 

Minutes of the June 2019 Meeting

 

 

Minutes

Meeting :

HTA Remit and Competitiveness Teleconference for NETS3 HTA Tobacco Cessation, control and harm reduction interventions, Researcher-Led Primary Research and Evidence Synthesis Applications from the May 2019 Call Close

Date and time :

Wednesday 05 June 2019, 10:00-13:00

Place :

Haygarth room, Beta House

Present :

 

Professor Hywel Williams (Chair)

Professor Steve Goodacre

Professor Lucy Chappell

Professor Andrew Farmer

Dr Ira Madan

Dr Geoff Wong

Professor David Sebag-Montefiore

 

NETSCC:

 

 

Dr Martin Ashton-Key (Consultant Advisor)

Mrs Karen Williams (Senior Research Manager)

Dr Cristina Lujan Barroso (Research Manager)

Miss Louisa Saunders (Assistant Research Manager)

 

Observers:

 

None

 

Apologies :

Associate Professor Kamal Mahtani, Professor Andrew Bradbury, Dr Simon Fraser, Miss Louise Maclachlan, Ms Maria Oosterwijk

 

 

 

 

18/166 HTA Tobacco Cessation, control and harm reduction intervention

1

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129166 - E-cigarettes for Quitting Smoking in Young People: A Randomised Controlled Trial (EQuiYP)

Dr Lynne Dawkins

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

2

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129438 - Smoking cessation in the Emergency Department: a randomised controlled trial

Dr Ian Pope

 

Chair: Hywel Williams

Declared a conflict and left the call: Steve Goodacre

 

Recommendation: Proceed to Funding Committee

3

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129593 - Investigating the effectiveness of electronic cigarettes as an aid to smoking cessation in comparison with varenicline and the effect of vaping on lung health in patients with chronic obstructive pulmonary disease (E-CaL study)

Dr Amanda Farley

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Proceed to Funding Committee

4

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129607 - E-cigarettes plus behavioural and psychological support for smoking cessation for users of community secondary mental health care: A cluster-randomised and controlled trial feasibility study

Dr Gemma Taylor

 

Chair: Hywel Williams

Declared a conflict and left the call: Andrew Farmer, Geoff Wong

 

Recommendation: Out of Remit

5

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129627 - Do e-cigarettes help smokers quit when not accompanied by intensive behavioural support?

Dr Katie Myers Smith

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Proceed to Funding Committee

6

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129636 - Examining feasibility, efficacy, clinical-effectiveness and cost-effectiveness of a novel digital platform for the delivery of assessment, triage and intervention for population-wide smoking cessation support: ‘My Quit Route’

Mrs Stephanie Dugdale

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

7

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129735 - Health effects of short-term and long-term use of e-cigarettes

Professor Peter Hajek

 

Chair: Hywel Williams

Declared a conflict and left the call: Andrew Farmer, Geoff Wong

 

Recommendation: Proceed to Funding Committee

8

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129210 - Open-label, randomised controlled trial of nicotine replacement therapy preloading and lapse recovery for cessation and where quitting fails, for smoking reduction in pregnancy

Professor Tim Coleman

 

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams, Andrew Farmer, Geoff Wong

 

Recommendation: Proceed to Funding Committee

 

 19/11 HTA Researcher-led call Primary Research

9

19/11 HTA Researcher-led call Primary Research

NIHR129025 - WrIst Physiotherapy Interventions in Trauma (WIPIT Study)

Associate-Professor Ben Ollivere

 

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams

 

Recommendation: Proceed to Funding Committee

10

19/11 HTA Researcher-led call Primary Research

NIHR128977 - EDAM: Evaluating Dislocated Acromioclavicular joint Management

Associate-Professor Rebecca Kearney

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

11

19/11 HTA Researcher-led call Primary Research

NIHR129001 - Post-stroke Intervention Trial in fatigue (POSITIF): a randomised controlled trial of a guided self help intervention for treating post-stroke fatigue

Professor Gillian Mead

 

Chair: Hywel Williams

Declared a conflict and left the call: Geoff Wong

 

Recommendation: Out of Remit

12

19/11 HTA Researcher-led call Primary Research

NIHR129114 - SISTAR: Outcomes of simultaneous versus staged resections for synchronous colorectal liver metastases – a randomised controlled trial

Mr Giuseppe Fusai

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Proceed to Funding Committee

13

19/11 HTA Researcher-led call Primary Research

NIHR129172 - A radical Steroid AVoidance trial in ANti-Neutrophil cytoplasm Antibody (ANCA) associated vasculitis (SAVANNA)

Professor Alan Salama

 

Chair: Hywel Williams

Declared a conflict and left the call: Lucy Chappell

 

Recommendation: Uncompetitive

14

19/11 HTA Researcher-led call Primary Research

NIHR129189 - Quetiapine augmentation of antidepressants for treatment resistant depression

Professor Glyn Lewis

 

Chair: Hywel Williams

Declared a conflict and left the call: Lucy Chappell

 

Recommendation: Uncompetitive

15

19/11 HTA Researcher-led call Primary Research

NIHR129197 - Children’s Ear Drops for eAR pain2 (CEDAR2): pragmatic randomised controlled trial

Professor Alastair Hay

 

Chair: Hywel Williams

Declared a conflict and left the call: Lucy Chappell

 

Recommendation: Out of Remit

16

19/11 HTA Researcher-led call Primary Research

NIHR129693 - BUDSURF - Randomised controlled trial of Budesonide-Surfactant for the prevention of Chronic Lung Disease in extreme preterm infants

Dr Mallinath Chakraborty

 

Chair: Hywel Williams

Declared a conflict and left the call: Lucy Chappell

 

Recommendation: Uncompetitive

17

19/11 HTA Researcher-led call Primary Research

NIHR129731 - Maternal POsition in the second stage of labour in nulliparous Women Without EpiduRal analgeSia: a randomised controlled trial (POWWERS)

Dr Caroline Fox

 

Chair: Andrew Bradbury

Declared a conflict and left the call: Lucy Chappell

 

Recommendation: Out of Remit

18

19/11 HTA Researcher-led call Primary Research

NIHR129237 - A randomised controlled trial of low intensity psychological treatment for depression for autistic adults

Dr Ailsa Russell

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Uncompetitive

19

19/11 HTA Researcher-led call Primary Research

NIHR129385 - RAPTOR: Randomised Controlled Trial of PENTOCLO in Mandibular Osteoradionecrosis

Professor Richard Shaw

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Proceed to Funding Committee

20

19/11 HTA Researcher-led call Primary Research

NIHR129518 - A randomised controlled trial to determine the effect and cost-effectiveness of liberal and conservative perioperative oxygen therapy on clinical outcomes following major surgery.

Dr Daniel Martin

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Proceed to Funding Committee

21

19/11 HTA Researcher-led call Primary Research

NIHR129531 - Long-term outcomes following breast conservation versus mastectomy in women aged 40 years or under with breast cancer  stratified by BRCA status: POSH study follow-up extension

Dr Ellen Copson

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Uncompetitive

22

19/11 HTA Researcher-led call Primary Research

NIHR129550 - MIDAS Trial: Modifying pain using Drugs Around Surgery. A randomised, double-blind, placebo-controlled trial of ibuprofen to safely reduce pain after major gastrointestinal surgery.

Dr Michael Gillies

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Proceed to Funding Committee

23

19/11 HTA Researcher-led call Primary Research

NIHR129551 - CanACT2: Acceptance and Commitment Therapy versus treatment as usual for psychosocial dysfunction in people with advanced cancer; a randomised controlled trial.

Dr Marc Serfaty

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

24

19/11 HTA Researcher-led call Primary Research

NIHR129557 - Evaluating the role of fast MRI and image-fusion biopsy for the detection of prostate cancer

Professor Hashim Ahmed

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

25

19/11 HTA Researcher-led call Primary Research

NIHR129564 - Use of high-flow humidified oxygen TheRapy versus stAndard Care following major HEad & neck surgery: A multi-site randomIsed controlled tRial (TRACHE-AIR)

Mr Paul Twose

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

26

19/11 HTA Researcher-led call Primary Research

NIHR129580 - WHiTE 12-WHISH: Wound Healing in Surgery for Hip fractures

Professor Matthew Costa

 

Chair: Hywel Williams

Declared a conflict and left the call: Andrew Farmer

 

Recommendation: Uncompetitive

27

19/11 HTA Researcher-led call Primary Research

NIHR129589 - ORBITA-2: A placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina

Professor Darrel Francis

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Proceed to Funding Committee

28

19/11 HTA Researcher-led call Primary Research

NIHR129576 - ENCOMPASS (MYELOMA). EvaluatioN of COMorbidity and suPportive therApy StrategieS in MYELOMA

Professor Gordon Cook

 

Chair: Hywel Williams

Declared a conflict and left the call: Steve Goodacre, David Sebag-Montefiore

 

Recommendation: Out of Remit

29

19/11 HTA Researcher-led call Primary Research

NIHR129002 - Exploring the effectiveness and cost-effectiveness of a community-based, exercise intervention with an embedded qualitative process evaluation for people with systemic sclerosis (EXCEL - SSc)

Dr Markos Klonizakis

 

Chair: Hywel Williams

Declared a conflict and left the call: Steve Goodacre

 

Recommendation: Out of Remit

30

19/11 HTA Researcher-led call Primary Research

NIHR129711 - The NOTES Study: Neonatal Outcomes with Treatments for Epileptic Seizures. A randomised controlled trial of phenobarbital and levetiracetam for seizures associated with neonatal hypoxic ischaemic encephalopathy and their association with neuro-development outcome at 2 years

Dr Anthony Hart

 

Chair: Hywel Williams

Declared a conflict and left the call: Steve Goodacre

 

Recommendation: Out of Remit

31

19/11 HTA Researcher-led call Primary Research

NIHR129592 - Cervical Orthoses in the Management of FragilitY Fractures of the Odontoid Process (COMFY)

Mr James Tomlinson

 

Chair: Andrew Farmer

Declared a conflict and left the call: Hywel Williams, Steve Goodacre

 

Recommendation: Out of Remit

32

19/11 HTA Researcher-led call Primary Research

NIHR129617 - Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury (MOSAICC – Multicentre evaluation Of Sodium bicarbonate in Acute kidney Injury in Critical Care)

Professor Lui Forni

 

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams

 

Recommendation: Proceed to Funding Committee

33

19/11 HTA Researcher-led call Primary Research

NIHR129677 - MUlticentre randomised trial of Surveillance in Inflammatory Bowel Disease (IBD): a comparison of dye spray chromoendoscopy  (DCE) versus  dyeless virtual electronic chromoendoscopy (VCE)  (MUSIc) for precise detection and outcome of colonic neoplasia in IBD patients

Associate-Professor Marietta Iacucci

 

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams

 

Recommendation: Out of Remit

34

19/11 HTA Researcher-led call Primary Research

NIHR129683 - Full Title: A cluster randomised controlled trial of using the enhanced liver fibrosis test in primary care to identify people at risk of liver fibrosis due to alcohol use disorders. Short title: DELIVER DEtecting LIVer damage using ELF In patients at RISK

Professor William Rosenberg

 

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams

 

Recommendation: Out of Remit

35

19/11 HTA Researcher-led call Primary Research

NIHR129628 - LIVACOR Trial: Minimally invasive LIVer And simultaneous COlorectal Resection

Professor Mohammed Abu Hilal

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Uncompetitive

36

19/11 HTA Researcher-led call Primary Research

NIHR129640 - Whole-body MRI for more efficient staging of breast cancer: internal pilot to inform a prospective multicentre comparison with standard imaging pathways.

Professor Steve Halligan

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

37

19/11 HTA Researcher-led call Primary Research

NIHR129664 - The Effectiveness of Peroneal Nerve Functional Electrical STimulation (FES) for the Reduction of Bradykinesia in Parkinson’s DiSease: A Pragmatic Assessor Blinded Randomised Controlled Trial (STEPS II).

Professor Paul Taylor

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

38

19/11 HTA Researcher-led call Primary Research

NIHR129668 - The use of 3D-printed insoles to prevent primary diabetic foot ulcers: a feasibility study.

Dr Panagiotis Chatzistergos

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

39

19/11 HTA Researcher-led call Primary Research

NIHR129679 - A pragmatic multi-centre randomised controlled trial of alcohol assertive outreach treatment for patients admitted to hospital with alcohol-related liver disease (A-LIVE)

Professor Colin Drummond

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

40

19/11 HTA Researcher-led call Primary Research

NIHR129690 - Diabetes Remission Clinical Trial for South Asians: The DISHA study

Professor Kamlesh Khunti

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Uncompetitive

41

19/11 HTA Researcher-led call Primary Research

NIHR129701 - Evidence-based pain management pathway for people with chronic pancreatitis

Professor Kurinchi Gurusamy

 

Chair: Hywel Williams

Declared a conflict and left the call: Geoff Wong

 

Recommendation: Proceed to Funding Committee - Commissioning

42

19/11 HTA Researcher-led call Primary Research

NIHR129707 - UrodynAmicS as Routine Evaluation in Women with StrEss UrinaRy InconTinence (The ASSERT Study); a superiority randomised clinical trial to evaluate the clinical and cost effectiveness of routine urodynamic investigations in management of women with stress

Professor Mohamed Abdel-Fattah

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

43

19/11 HTA Researcher-led call Primary Research

NIHR129710 - A randomised control trial to determine the influence of metformin on the growth of large abdominal aortic aneurysms in patients without diabetes who are unsuitable for surgical intervention (MEASURE – Metformin Effect on Aneurysm Size in patients Unfit for Repair)

Professor Robert Hinchliffe

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

44

19/11 HTA Researcher-led call Primary Research

NIHR129727 - Improving outcomes for men undergoing Open AAA Repair using Prehabilitation

Mr Tristan Lane

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

45

19/11 HTA Researcher-led call Primary Research

NIHR129728 - Impact of green tea extract on cognition and function in older adults at risk of cognitive decline and dementia: A randomised controlled trial

Dr Anne Corbett

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

46

19/11 HTA Researcher-led call Primary Research

NIHR129748 - Surgeons Trial Of Prophylaxis for Epilepsy in seizure naïve patients with Meningioma: a randomised controlled trial (STOP’EM)

Mr Michael Jenkinson

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Proceed to Funding Committee

47

19/11 HTA Researcher-led call Primary Research

NIHR129753 - Social Prescribing for Children and Young People

Professor Barry Wright

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

48

19/11 HTA Researcher-led call Primary Research

NIHR129756 – TENSION (Trial EmbolisatioN IN oSteOarthritis)

Dr Nolan Walker

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Out of Remit

49

19/11 HTA Researcher-led call Primary Research

NIHR129718 - Music Interventions for Dementia and Depression in ELderly care (MIDDEL): International cluster-randomised trial - UK arm (MIDDEL-UK)

Professor Justine Schneider

 

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams

 

Recommendation: Proceed to Funding Committee

50

19/11 HTA Researcher-led call Primary Research

NIHR129079 - The AVERT (Acute VErtebral fragility fractuRe augmenTation) study in hospitalised patients.

Professor Opinder Sahota

 

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams

 

Recommendation: Out of Remit

51

19/11 HTA Researcher-led call Primary Research

NIHR129179 - PREDNOS 3: what is the optimal steroid treatment dose to induce remission in relapses of childhood nephrotic syndrome?

Dr Martin Christian

 

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams

 

Recommendation: Proceed to Funding Committee

52

19/10 HTA Researcher-led call Evidence Synthesis

 

19/10 HTA Researcher-led call Evidence Synthesis

NIHR129305 - Clinical and cost-effectiveness of early interventions initiated in the acute care period for managing the psychological effects of trauma and to reduce the incidence and duration of common mental disorders.

Dr Philippa Olive

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Uncompetitive

53

19/10 HTA Researcher-led call Evidence Synthesis

NIHR129523 - BEhavioural Weight Management: COMponents of Effectiveness (BE:COME)

Dr Jennifer Logue

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Proceed to Funding Committee

54

19/10 HTA Researcher-led call Evidence Synthesis

NIHR129646 - Evaluating diagnostic performance of imaging technologies for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment: a systematic review and meta-analysis

Dr Huiqin Yang

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Uncompetitive

55

19/10 HTA Researcher-led call Evidence Synthesis

NIHR129708 - Safety and effectiveness of tranexamic acid in trauma and surgery in the NHS: An individual patient data meta-analysis

Dr Katharine Ker

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Proceed to Funding Committee

56

19/10 HTA Researcher-led call Evidence Synthesis

NIHR129713 - Effectiveness and cost-effectiveness of gynaecological surveillance for women with Lynch syndrome: systematic reviews and economic evaluation

Dr Tristan Snowsill

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Proceed to Funding Committee

57

19/10 HTA Researcher-led call Evidence Synthesis

NIHR129715 - Diet and physical activity in pregnancy to prevent gestational diabetes: Individual Participant Data (IPD) meta-analysis on the differential effects of interventions with economic evaluation

Professor Shakila Thangaratinam

 

Chair: Hywel Williams

Declared a conflict and left the call: Lucy Chappell

 

Recommendation: Proceed to Funding Committee

58

19/10 HTA Researcher-led call Evidence Synthesis

NIHR129742 - Systematic Review and meta-analysis of clinical and cost effectiveness and feasibility of a UK extracorporeal cardiopulmonary resuscitation programme for out-of-hospital cardiac arrests

Associate-Professor Joyce Yeung

 

Chair: Hywel Williams

Declared a conflict and left the call: Steve Goodacre

 

Recommendation: Proceed to Funding Committee

59

19/11 HTA Researcher-led call Primary Research

 

19/11 HTA Researcher-led call Primary Research

NIHR129750 - Prostate cancer Risk Evaluation by Freehand transperineal sectoral (FHTP-24 core) versus Evaluation by Reduced (FHTP–12 core) biopsy: Randomisation for Effective Diagnosis. A randomised non-inferiority trial. Short Title: PREFERRED

Mr Rick Popert

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Uncompetitive

60

19/11 HTA Researcher-led call Primary Research

NIHR129649 - A multicentre randomised placebo-controlled trial of the effectiveness and cost-effectiveness of conventional vs high-frequency spinal cord stimulation in patients with neuropathic pain. CHESTNUT STUDY

Professor Sam Eldabe

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Proceed to Funding Committee

61

19/11 HTA Researcher-led call Primary Research

NIHR127873 - Pragmatic randomised trial of High Or Standard PHosphAte Targets in End-stage kidney disease - The PHOSPHATE trial

Dr Thomas Hiemstra

 

Chair: Hywel Williams

Declared a conflict and left the call: None

 

Recommendation: Proceed to Funding Committee

 

Summing up

 

18/166 - HTA Tobacco Cessation, control and harm reduction interventions (NETS3 call) – Primary Research

18/166 - HTA Tobacco Cessation, control and harm reduction interventions (NETS3 call) – Primary Research

1.1

NIHR129166

E-cigarettes for Quitting Smoking in Young People: A Randomised Controlled Trial (EQuiYP)

(Dr Lynne Dawkins)

Decision: Out of remit

1.2

NIHR129438

Smoking cessation in the Emergency Department: a randomised controlled trial

(Dr Ian Pope)

Decision: Proceed to Funding Committee

1.3

NIHR129593

Investigating the effectiveness of electronic cigarettes as an aid to smoking cessation in comparison with varenicline and the effect of vaping on lung health in patients with chronic obstructive pulmonary disease (E-CaL study)

(Dr Amanda Farley)

Decision: Proceed to Funding Committee

1.4

NIHR129607

E-cigarettes plus behavioural and psychological support for smoking cessation for users of community secondary mental health care: A cluster-randomised and controlled trial feasibility study

(Dr Gemma Taylor)

Decision: Out of remit

1.5

NIHR129627

Do e-cigarettes help smokers quit when not accompanied by intensive behavioural support?

(Dr Katie Myers Smith)

Decision: Proceed to Funding Committee

1.6

NIHR129636

Examining feasibility, efficacy, clinical-effectiveness and cost-effectiveness of a novel digital platform for the delivery of assessment, triage and intervention for population-wide smoking cessation support: ‘My Quit Route’

(Mrs Stephanie Dugdale)

Decision: Out of remit

1.7

NIHR129735

Health effects of short-term and long-term use of e-cigarettes

(Professor Peter Hajek)

Decision: Proceed to Funding Committee

1.8

NIHR129210

Open-label, randomised controlled trial of nicotine replacement therapy preloading and lapse recovery for cessation and where quitting fails, for smoking reduction in pregnancy

(Professor Tim Coleman)

Decision: Proceed to Funding Committee

 

 

19/11 HTA Researcher-led call - Primary Research

1.9

NIHR129025

WrIst Physiotherapy Interventions in Trauma (WIPIT Study)

(Associate-Professor Ben Ollivere)

Decision: Proceed to Funding Committee

1.10

NIHR128977

EDAM: Evaluating Dislocated Acromioclavicular joint Management

(Associate-Professor Rebecca Kearney)

Decision: Out of remit

1.11

NIHR129001

Post-stroke Intervention Trial in fatigue (POSITIF): a randomised controlled trial of a guided self help intervention for treating post-stroke fatigue

(Professor Gillian Mead)

Decision: Out of remit

1.12

NIHR129114

SISTAR: Outcomes of simultaneous versus staged resections for synchronous colorectal liver metastases – a randomised controlled trial

(Mr Giuseppe Fusai)

Decision: Proceed to Funding Committee

1.13

NIHR129172

A radical Steroid AVoidance trial in ANti-Neutrophil cytoplasm Antibody (ANCA) associated vasculitis (SAVANNA)

(Professor Alan Salama)

Decision: Uncompetitive

1.14

NIHR129189

Quetiapine augmentation of antidepressants for treatment resistant depression

(Professor Glyn Lewis)

Decision: Uncompetitive

1.15

NIHR129197

Children’s Ear Drops for eAR pain2 (CEDAR2): pragmatic randomised controlled trial

(Professor Alastair Hay)

Decision: Out of remit

1.16

NIHR129693

BUDSURF - Randomised controlled trial of Budesonide-Surfactant for the prevention of Chronic Lung Disease in extreme preterm infants

(Dr Mallinath Chakraborty)

Decision: Uncompetitive

1.17

NIHR129731

Maternal POsition in the second stage of labour in nulliparous Women Without EpiduRal analgeSia: a randomised controlled trial (POWWERS)

(Dr Caroline Fox)

Decision: Out of remit

1.18

NIHR129237

A randomised controlled trial of low intensity psychological treatment for depression for autistic adults

(Dr Ailsa Russell)

Decision: Uncompetitive

1.19

NIHR129385

RAPTOR: Randomised Controlled Trial of PENTOCLO in Mandibular Osteoradionecrosis

(Professor Richard Shaw)

Decision: Proceed to Funding Committee

1.20

NIHR129518

A randomised controlled trial to determine the effect and cost-effectiveness of liberal and conservative perioperative oxygen therapy on clinical outcomes following major surgery.

(Dr Daniel Martin)

Decision: Proceed to Funding Committee

1.21

NIHR129531

Long-term outcomes following breast conservation versus mastectomy in women aged 40 years or under with breast cancer  stratified by BRCA status: POSH study follow-up extension

(Dr Ellen Copson)

Decision: Uncompetitive

1.22

NIHR129550

MIDAS Trial: Modifying pain using Drugs Around Surgery. A randomised, double-blind, placebo-controlled trial of ibuprofen to safely reduce pain after major gastrointestinal surgery.

(Dr Michael Gillies)

Decision: Proceed to Funding Committee

1.23

NIHR129551

CanACT2: Acceptance and Commitment Therapy versus treatment as usual for psychosocial dysfunction in people with advanced cancer; a randomised controlled trial.

(Dr Marc Serfaty)

Decision: Out of remit

1.24

NIHR129557

Evaluating the role of fast MRI and image-fusion biopsy for the detection of prostate cancer

(Professor Hashim Ahmed)

Decision: Out of remit

1.25

NIHR129564

Use of high-flow humidified oxygen TheRapy versus stAndard Care following major HEad & neck surgery: A multi-site randomIsed controlled tRial (TRACHE-AIR)

(Mr Paul Twose)

Decision: Out of remit

1.26

NIHR129580

WHiTE 12-WHISH: Wound Healing in Surgery for Hip fractures

(Professor Matthew Costa)

Decision: Uncompetitive

1.27

NIHR129589

ORBITA-2: A placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina

(Professor Darrel Francis)

Decision: Proceed to Funding Committee

1.28

NIHR129576

ENCOMPASS (MYELOMA)

EvaluatioN of COMorbidity and suPportive therApy StrategieS in MYELOMA

(Professor Gordon Cook)

Decision: Out of remit

1.29

NIHR129002

Exploring the effectiveness and cost-effectiveness of a community-based, exercise intervention with an embedded qualitative process evaluation for people with systemic sclerosis (EXCEL - SSc)

(Dr Markos Klonizakis)

Decision: Out of remit

1.30

NIHR129711

The NOTES Study: Neonatal Outcomes with Treatments for Epileptic Seizures

A randomised controlled trial of phenobarbital and levetiracetam for seizures associated with neonatal hypoxic ischaemic encephalopathy and their association with neuro-developme

(Dr Anthony Hart)

Decision: Out of remit

1.31

NIHR129592

Cervical Orthoses in the Management of FragilitY Fractures of the Odontoid Process (COMFY)

(Mr James Tomlinson)

Decision: Out of remit

1.32

NIHR129617

Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury (MOSAICC – Multicentre evaluation Of Sodium bicarbonate in Acute kidney Injury in Critical Care)

(Professor Lui Forni)

Decision: Proceed to Funding Committee

1.33

NIHR129677

MUlticentre randomised trial of Surveillance in Inflammatory Bowel Disease (IBD): a comparison of dye spray chromoendoscopy  (DCE) versus  dyeless virtual electronic chromoendoscopy (VCE)  (MUSIc) for precise detection and outcome of colonic neoplasia in I

(Associate-Professor Marietta Iacucci)

Decision: Out of remit

1.34

NIHR129683

Full Title: A cluster randomised controlled trial of using the enhanced liver fibrosis test in primary care to identify people at risk of liver fibrosis due to alcohol use disorders. Short title: DELIVER DEtecting LIVer damage using ELF In patients at

(Professor William Rosenberg)

Decision: Out of remit

1.35

NIHR129628

LIVACOR Trial: Minimally invasive LIVer And simultaneous COlorectal Resection

(Professor Mohammed Abu Hilal)

Decision: Uncompetitive

1.36

NIHR129640

Whole-body MRI for more efficient staging of breast cancer: internal pilot to inform a prospective multicentre comparison with standard imaging pathways.

(Professor Steve Halligan)

Decision: Out of remit

1.37

NIHR129664

The Effectiveness of Peroneal Nerve Functional Electrical STimulation (FES) for the Reduction of Bradykinesia in Parkinson’s DiSease: A Pragmatic Assessor Blinded Randomised Controlled Trial (STEPS II).

(Professor Paul Taylor)

Decision: Out of remit

1.38

NIHR129668

The use of 3D-printed insoles to prevent primary diabetic foot ulcers: a feasibility study.

(Dr Panagiotis Chatzistergos)

Decision: Out of remit

1.39

NIHR129679

A pragmatic multi-centre randomised controlled trial of alcohol assertive outreach treatment for patients admitted to hospital with alcohol-related liver disease (A-LIVE)

(Professor Colin Drummond)

Decision: Out of remit

1.40

NIHR129690

Diabetes Remission Clinical Trial for South Asians: The DISHA study

(Professor Kamlesh Khunti)

Decision: Uncompetitive

1.41

NIHR129701

Evidence-based pain management pathway for people with chronic pancreatitis

(Professor Kurinchi Gurusamy)

Decision: Proceed to Funding Committee

1.42

NIHR129707

UrodynAmicS as Routine Evaluation in Women with StrEss UrinaRy InconTinence (The ASSERT Study); a superiority randomised clinical trial to evaluate the clinical and cost effectiveness of routine urodynamic investigations in management of women with stress

(Professor Mohamed Abdel-Fattah)

Decision: Proceed to Funding Committee

1.43

NIHR129710

A randomised control trial to determine the influence of metformin on the growth of large abdominal aortic aneurysms in patients without diabetes who are unsuitable for surgical intervention (MEASURE – Metformin Effect on Aneurysm Size in patients Unfi

(Professor Robert Hinchliffe)

Decision: Out of remit

1.44

NIHR129727

Improving outcomes for men undergoing Open AAA Repair using Prehabilitation

(Mr Tristan Lane)

Decision: Out of remit

1.45

NIHR129728

Impact of green tea extract on cognition and function in older adults at risk of cognitive decline and dementia: A randomised controlled trial

(Dr Anne Corbett)

Decision: Out of remit

1.46

NIHR129748

Surgeons Trial Of Prophylaxis for Epilepsy in seizure naïve patients with Meningioma: a randomised controlled trial (STOP’EM)

(Mr Michael Jenkinson)

Decision: Proceed to Funding Committee

1.47

NIHR129753

Social Prescribing for Children and Young People (Professor Barry Wright)

Decision: Out of remit

1.48

NIHR129756

TENSION (Trial EmbolisatioN IN oSteOarthritis)

(Dr Nolan Walker)

Decision: Out of remit

1.49

NIHR129718

Music Interventions for Dementia and Depression in ELderly care (MIDDEL): International cluster-randomised trial - UK arm (MIDDEL-UK)

(Professor Justine Schneider)

Decision: Proceed to Funding Committee

1.50

NIHR129079

The AVERT (Acute VErtebral fragility fractuRe augmenTation) study in hospitalised patients.

(Professor Opinder Sahota)

Decision: Out of remit

1.51

NIHR129179

PREDNOS 3: what is the optimal steroid treatment dose to induce remission in relapses of childhood nephrotic syndrome?

(Dr Martin Christian)

Decision: Proceed to Funding Committee

1.59

NIHR129750

Prostate cancer Risk Evaluation by Freehand transperineal sectoral (FHTP-24 core) versus Evaluation by Reduced (FHTP–12 core) biopsy: Randomisation for Effective Diagnosis. A randomised non-inferiority trial. Short Title: PREFERRED

(Mr Rick Popert)

Decision: Uncompetitive

 

19/10 HTA Researcher-led call - Evidence Synthesis

1.52

NIHR129305

Clinical and cost-effectiveness of early interventions initiated in the acute care period for managing the psychological effects of trauma and to reduce the incidence and duration of common mental disorders.

(Dr Philippa Olive)

Decision: Uncompetitive

1.53

NIHR129523

BEhavioural Weight Management: COMponents of Effectiveness (BE:COME)

(Dr Jennifer Logue)

Decision: Proceed to Funding Committee

1.54

NIHR129646

Evaluating diagnostic performance of imaging technologies for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment: a systematic review and meta-analysis

(Dr Huiqin Yang)

Decision: Uncompetitive

1.55

NIHR129708

Safety and effectiveness of tranexamic acid in trauma and surgery in the NHS: An individual patient data meta-analysis

(Dr Katharine Ker)

Decision: Proceed to Funding Committee

1.56

NIHR129713

Effectiveness and cost-effectiveness of gynaecological surveillance for women with Lynch syndrome: systematic reviews and economic evaluation

(Dr Tristan Snowsill)

Decision: Proceed to Funding Committee

1.57

NIHR129715

Diet and physical activity in pregnancy to prevent gestational diabetes: Individual Participant Data (IPD) meta-analysis on the differential effects of interventions with economic evaluation

(Professor Shakila Thangaratinam)

Decision: Proceed to Funding Committee

1.58

NIHR129742

Systematic Review and meta-analysis of clinical and cost effectiveness and feasibility of a UK extracorporeal cardiopulmonary resuscitation programme for out-of-hospital cardiac arrests

(Associate-Professor Joyce Yeung)

Decision: Proceed to Funding Committee

 

 19/11 HTA Researcher-led call – Primary Research

1.60

NIHR129649

A multicentre randomised placebo-controlled trial of the effectiveness and cost-effectiveness of conventional vs high-frequency spinal cord stimulation in patients with neuropathic pain. CHESTNUT STUDY

(Professor Sam Eldabe)

Decision: Proceed to Funding Committee

1.61

NIHR127873

Pragmatic randomised trial of High Or Standard PHosphAte Targets in End-stage kidney disease - The PHOSPHATE trial

(Dr Thomas Hiemstra)

Decision: Proceed to Funding Committee