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Health Technology Assessment

The Health Technology Assessment (HTA) Programme funds research about the clinical and cost-effectiveness and broader impact of healthcare treatments and tests for those who plan, provide or receive care from NHS and social care services.


The Health Technology Assessment (HTA) Programme is funded by the NIHR with specific contributions from the Chief Scientist Office (CSO) in Scotland, Health and Care Research Wales and the HSC R&D Division, Public Health Agency in Northern Ireland.

HTA research is undertaken where some evidence already exists to show that a technology can be effective and this needs to be compared to the current standard intervention to see which works best.

Research can evaluate any intervention used in the treatment, prevention or diagnosis of disease, provided the study outcomes lead to findings that have the potential to be of direct benefit to NHS patients.

The HTA programme needs to be convinced that an intervention is ready for HTA evaluation. We've prepared a document outlining the issues that may determine this judgement.

The researcher-led workstream offers researchers the opportunity to submit proposals on topics or research questions within the programme’s remit. The commissioned workstream invites applications in response to calls for research on specific questions which have been identified and prioritised for their importance to the NHS and patients. Proposals may include primary research, evidence synthesis, or feasibility and pilot studies when requested within the commissioning brief.

All of our funded projects are eligible for publication in the NIHR Journals Library. This open access resource  is freely available online, and provides a full and permanent record of NIHR-funded research.

The Health Technology Assessment (HTA) Programme supports research that is immediately useful to patients, clinical practice, and policy or decision makers.

HTA research is undertaken when evidence exists to show that a technology can be effective. The purpose of an HTA study is to establish the clinical and cost-effectiveness for the NHS in comparison with the current best alternative(s).  A study may also investigate uncertainty around a technology’s place in the existing care pathway.

“Technologies” in this context mean any method used to promote health; prevent and treat disease; and improve rehabilitation or long-term care. They are not confined to new drugs and include any intervention used in the treatment, prevention or diagnosis of disease.

  • Examples include:
  • procedures
  • drugs
  • devices
  • diagnostic tests
  • settings of care
  • screening programmes

The technology doesn't necessarily need to exist in current NHS practice, but a study would need to show that it could.

Health Technology Assessment asks important questions about these technologies such as:

  • when is counselling better than drug treatment for depression?
  • what is the best operation for aortic aneurysms?
  • should we screen for human papilloma virus when doing cervical smears?
  • should aspirin be used for the primary prevention of cardiovascular disease?

It answers these questions by investigating four main factors:

  • whether the technology works
  • for whom
  • at what cost
  • how it compares with the alternatives

The HTA Programme will support:

  • systematic reviews
  • economic models
  • meta-analyses
  • mixed-treatment comparisons
  • expected Value of Information studies
  • randomised controlled trials (unblinded, single-blinded, double-blinded, triple-blinded)
  • non-randomised trials
  • single-centre studies where a strong case has been made for this type of design and there is assurance the results will be generalizable to the wider NHS
  • cohort studies (retrospective or prospective)
  • adaptive designs
  • modelling studies
  • international studies

The HTA Programme will not support:

  • phase 2 trials (our EME Programme may be more suitable)
  • research on new equipment
  • PhD research
  • proposals currently pending with another research funder
  • The HTA will not fund standalone pilot and feasibility studies unless requested within a commissioning brief

See the success rates for HTA proposals.

In this section you can read more on the people involved in the assessment of applications for the Health Technology Assessment (HTA) Programme, and find out more about becoming a reviewer or a Committee member.

New developments in health research funding are transforming the way research in the NHS is organised and carried out. The HTA  Programme invites and works with a range of individuals to meet the research needs of the NHS. Their support and input allows us to fund high-quality, evidence-based, value for money research.

The people who work in, work with or use NHS services provide vital input into all stages of the HTA Programme.

Members of NIHR Committees are required to declare any interests which conflict, or may be considered to conflict, with NIHR business, or may be perceived as influencing decisions made in the course of their work within NIHR. All members are asked to complete the Register of Interest form (annually), which is intended to capture long term predictable interests that could be perceived to lead to conflicts of interest. These and other interests are judged on a case by case basis at individual meetings.

Our Director

Professor Hywel Williams

Watch the latest director's message 

Our committees

The HTA Committees meet three times a year to assess the scientific merit of proposals submitted to both the commissioned and researcher-led workstreams, including themed calls and evidence synthesis proposals, and to make funding recommendations to the Programme Oversight Committee. You can view the members of our committees on the links below:

HTA Funding Committee (General)

HTA Funding Committee (Commissioning)

HTA Funding Committee Clinical Evaluation and Trials

HTA Prioritisation Committee: Integrated community health and social care

HTA Prioritisation Committee: Hospital based care

HTA Prioritisation Committee: Maternal, child and mental health care

HTA Programme Oversight Committee

Funding Committee minutes and outcomes


To assure the scientific quality of its research, the HTA Programme relies upon the help of external reviewers to review:

  • the research and commissioning briefs it produces
  • the research proposals it receives
  • the final reports of research findings

External reviewers play a vital part in maintaining and improving the quality of HTA Programme research and are sought from a variety of fields, including clinical, methodological and those who use NHS services. View a list of HTA reviewers.

We offer a wide variety of assistance during all stages of the research process. If in doubt, please get in touch.

For help with applying for HTA funding:

Commissioned calls

Tel: 023 8059 5510

Researcher-led calls

Tel: 023 8059 5544

General queries


Latest funding opportunities for Health Technology Assessment

20/45 COVID-19: Recovery and Learning

This cross-programme funding opportunity is open for two rounds.

20/22 Rectus sheath blockade in emergency laparotomy

The Health Technology Assessment Programme is accepting stage 1 applications to their commissioned workstream for this primary research topic.

20/37 Health Technology Assessment Programme Researcher-led (evidence synthesis

The Health Technology Assessment Programme is accepting stage 1 applications to their researcher-led workstream.

20/38 Health Technology Assessment Programme Researcher-led (primary research)

The Health Technology Assessment Programme is accepting stage 1 applications to their researcher-led workstream.

20/40 HTA oral and dental health

The EME, HS&DR, HTA and PHR Programmes are all accepting applications for this funding opportunity.

All HTA funding opportunities

Latest documents for Health Technology Assessment

HTA Funding Committee Public Minutes 19-20 May 2020

HTA Funding Committee (Commissioning) Public Minutes 19-20 May 2020

HTA Funding Committee Deputy Chair vacancy - applicant guidance notes

Guidance for applicants for HTA Funding Committee Deputy Chair vacancy

NIHR HTA Funding Committee Public Minutes 17-18 March 2020

HTA Funding Committee March 17-18 March 2020

NIHR HTA Funding Committee Public Minutes 10-11 March 2020

HTA Funding Committee (CET) Public Minutes 10-11 March 2020

HTA researcher-led open call specification document

Specification document for those applying to the HTA researcher-led open call for primary research and evidence synthesis

All HTA documents